Nephrotic syndrome: don't forget to search for hypothyroidism
If abnormal thyroid function indices have been reported in patients with nephrotic syndrome, hypothyroidism is exceptional. We report three adult patients (1, 2, 3) with hypothyroidism associated with nephrotic syndrome (minimal change glomerulonephritis [1], idiopathic membranous nephropathy stage...
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| Veröffentlicht in: | La revue de medecine interne 2008-02, Vol.29 (2), p.139-144 |
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| creator | Trouillier, S Delèvaux, I Rancé, N André, M Voinchet, H Aumaître, O |
| description | If abnormal thyroid function indices have been reported in patients with nephrotic syndrome, hypothyroidism is exceptional.
We report three adult patients (1, 2, 3) with hypothyroidism associated with nephrotic syndrome (minimal change glomerulonephritis [1], idiopathic membranous nephropathy stage I [2], stage II [3]). Glomerulopathy treatment and thyroid hormone replacement therapy were both initiated. Low replacement (1, 2) was sufficient when proteinuria decreased. It was higher when nephrotic syndrome was uncontrolled (3).
Excessive thyroxine-binding protein and thyroxine urinary loss generate low rate of free thyroxine and elevated TSH. Systematic thyroid hormonal test is necessary if nephrotic syndrome is severe and prolonged. |
| doi_str_mv | 10.1016/j.revmed.2007.10.412 |
| format | Article |
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We report three adult patients (1, 2, 3) with hypothyroidism associated with nephrotic syndrome (minimal change glomerulonephritis [1], idiopathic membranous nephropathy stage I [2], stage II [3]). Glomerulopathy treatment and thyroid hormone replacement therapy were both initiated. Low replacement (1, 2) was sufficient when proteinuria decreased. It was higher when nephrotic syndrome was uncontrolled (3).
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We report three adult patients (1, 2, 3) with hypothyroidism associated with nephrotic syndrome (minimal change glomerulonephritis [1], idiopathic membranous nephropathy stage I [2], stage II [3]). Glomerulopathy treatment and thyroid hormone replacement therapy were both initiated. Low replacement (1, 2) was sufficient when proteinuria decreased. It was higher when nephrotic syndrome was uncontrolled (3).
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We report three adult patients (1, 2, 3) with hypothyroidism associated with nephrotic syndrome (minimal change glomerulonephritis [1], idiopathic membranous nephropathy stage I [2], stage II [3]). Glomerulopathy treatment and thyroid hormone replacement therapy were both initiated. Low replacement (1, 2) was sufficient when proteinuria decreased. It was higher when nephrotic syndrome was uncontrolled (3).
Excessive thyroxine-binding protein and thyroxine urinary loss generate low rate of free thyroxine and elevated TSH. Systematic thyroid hormonal test is necessary if nephrotic syndrome is severe and prolonged.</abstract><cop>France</cop><pmid>18191306</pmid><doi>10.1016/j.revmed.2007.10.412</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged Angiotensin II Type 1 Receptor Blockers - therapeutic use Angiotensin-Converting Enzyme Inhibitors - therapeutic use Diuretics - therapeutic use Glomerulonephritis, Membranous - complications Glomerulonephritis, Membranous - diagnosis Glucocorticoids - therapeutic use Hormone Replacement Therapy Humans Hypothyroidism - complications Hypothyroidism - diagnosis Male Nephrosis, Lipoid - complications Nephrosis, Lipoid - diagnosis Nephrotic Syndrome - complications Nephrotic Syndrome - diagnosis Thyroxine - therapeutic use |
| title | Nephrotic syndrome: don't forget to search for hypothyroidism |
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