Recombinant porcine lactoferrin expressed in the milk of transgenic mice protects neonatal mice from a lethal challenge with enterovirus type 71

Summary The human Enterovirus genus of the piconavirus family causes most of the febrile illnesses that affect children during the summer season in Taiwan. Enterovirus type 71 (EV71) plays a key role in patients with hand-foot-and-mouth disease (HFMD) combined with severe paralysis or encephalitis....

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Veröffentlicht in:	Vaccine 2008-02, Vol.26 (7), p.891-898
Hauptverfasser:	Chen, Hsiao-Ling, Wang, Li-Chung, Chang, Chi-Hsuan, Yen, Chih-Ching, Cheng, Winston T.K, Wu, Shinn-Chih, Hung, Che-Ming, Kuo, Meng-Fu, Chen, Chuan-Mu
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animal models Animals Animals, Newborn Antimicrobial agents Antiviral activity Antiviral Agents - immunology Antiviral Agents - metabolism Biological and medical sciences Body Weight Child, Preschool Cytomegalovirus Deoxyribonucleic acid Disease Models, Animal DNA Enterovirus Enterovirus - isolation & purification Enterovirus - pathogenicity Enterovirus 71 Enterovirus Infections - mortality Enterovirus Infections - prevention & control Enterovirus Infections - virology Female Females Fundamental and applied biological sciences. Psychology HIV Human immunodeficiency virus Humans Infant, Newborn Infections Lactalbumin - genetics Lactalbumin - immunology Lactalbumin - metabolism Lactation Lactoferrin - genetics Lactoferrin - immunology Lactoferrin - metabolism Mammals Mice Mice, Inbred BALB C Mice, Transgenic Microbiology Milk Milk - chemistry Milk - metabolism Miscellaneous Mortality Neonatal viral infection Porcine lactoferrin Recombinant Proteins - genetics Recombinant Proteins - immunology Recombinant Proteins - metabolism Rodents Survival Swine Transgenic animals Transgenic mice Virology Yeast
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