Expression of Kir 4.1 in human astrocytic tumors: Correlation with pathologic grade
Inward rectifying potassium channels (Kir), and in particular Kir 4.1, are key regulators of glial functions, which in turn determine neuronal excitability and axonal conduction. A high expression of Kir 4.1 has been detected in in some pathological conditions. In this study, we investigated the exp...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2008-03, Vol.367 (4), p.743-747 |
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| creator | Tan, Ge Sun, Shan-quan Yuan, Dong-li |
| description | Inward rectifying potassium channels (Kir), and in particular Kir 4.1, are key regulators of glial functions, which in turn determine neuronal excitability and axonal conduction. A high expression of Kir 4.1 has been detected in in some pathological conditions. In this study, we investigated the expression of Kir 4.1 mRNA and protein in 80 cases of human astrocytic tumors by reverse transcription polymerase chain reaction, Western blot and immunohistochemistry, respectively. The correlation between Kir 4.1 expression and pathologic grade of astrocytic tumors was further analyzed. The results showed that the expression of Kir 4.1 mRNA and protein, as well as the Kir 4.1 immunoreactivity score (IRS), increased markedly with increasing pathologic grade. Therefore, Kir 4.1 may be a new biomarker for astrocytic tumors. It may also be an attractive therapy target for human astrocytic tumors. |
| doi_str_mv | 10.1016/j.bbrc.2008.01.014 |
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A high expression of Kir 4.1 has been detected in in some pathological conditions. In this study, we investigated the expression of Kir 4.1 mRNA and protein in 80 cases of human astrocytic tumors by reverse transcription polymerase chain reaction, Western blot and immunohistochemistry, respectively. The correlation between Kir 4.1 expression and pathologic grade of astrocytic tumors was further analyzed. The results showed that the expression of Kir 4.1 mRNA and protein, as well as the Kir 4.1 immunoreactivity score (IRS), increased markedly with increasing pathologic grade. Therefore, Kir 4.1 may be a new biomarker for astrocytic tumors. It may also be an attractive therapy target for human astrocytic tumors.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2008.01.014</identifier><identifier>PMID: 18191638</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Astrocytic tumors ; Astrocytoma - metabolism ; Biomarkers, Tumor - metabolism ; Brain Neoplasms - metabolism ; Child ; Female ; Glia ; Humans ; Inward rectifying potassium channels ; Kir 4.1 ; Male ; Middle Aged ; Neoplasm Proteins - metabolism ; Potassium Channels, Inwardly Rectifying - metabolism ; Statistics as Topic ; Tumor Cells, Cultured</subject><ispartof>Biochemical and biophysical research communications, 2008-03, Vol.367 (4), p.743-747</ispartof><rights>2008 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-84fc1dab4689334bd9556ac34b7a861b792a3b769f536b7e5e907d40a255bb313</citedby><cites>FETCH-LOGICAL-c385t-84fc1dab4689334bd9556ac34b7a861b792a3b769f536b7e5e907d40a255bb313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bbrc.2008.01.014$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18191638$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tan, Ge</creatorcontrib><creatorcontrib>Sun, Shan-quan</creatorcontrib><creatorcontrib>Yuan, Dong-li</creatorcontrib><title>Expression of Kir 4.1 in human astrocytic tumors: Correlation with pathologic grade</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>Inward rectifying potassium channels (Kir), and in particular Kir 4.1, are key regulators of glial functions, which in turn determine neuronal excitability and axonal conduction. A high expression of Kir 4.1 has been detected in in some pathological conditions. In this study, we investigated the expression of Kir 4.1 mRNA and protein in 80 cases of human astrocytic tumors by reverse transcription polymerase chain reaction, Western blot and immunohistochemistry, respectively. The correlation between Kir 4.1 expression and pathologic grade of astrocytic tumors was further analyzed. The results showed that the expression of Kir 4.1 mRNA and protein, as well as the Kir 4.1 immunoreactivity score (IRS), increased markedly with increasing pathologic grade. Therefore, Kir 4.1 may be a new biomarker for astrocytic tumors. It may also be an attractive therapy target for human astrocytic tumors.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Astrocytic tumors</subject><subject>Astrocytoma - metabolism</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Brain Neoplasms - metabolism</subject><subject>Child</subject><subject>Female</subject><subject>Glia</subject><subject>Humans</subject><subject>Inward rectifying potassium channels</subject><subject>Kir 4.1</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Proteins - metabolism</subject><subject>Potassium Channels, Inwardly Rectifying - metabolism</subject><subject>Statistics as Topic</subject><subject>Tumor Cells, Cultured</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtv1DAUhS1ERYfCH2CBsmKXcK9fiREbNCoPUamLgsTOsh2n41ESD7YD7b8noxmJHUhHunfxnbP4CHmF0CCgfLtvrE2uoQBdA7iGPyEbBAU1ReBPyQYAZE0V_rgkz3PeAyByqZ6RS-xQoWTdhtxdPxySzznEuYpD9TWkijdYhbnaLZOZK5NLiu6xBFeVZYopv6u2MSU_mnKs_A5lVx1M2cUx3q_MfTK9f0EuBjNm__J8r8j3j9fftp_rm9tPX7YfbmrHOlHqjg8Oe2O57BRj3PZKCGnc-rWmk2hbRQ2zrVSDYNK2XngFbc_BUCGsZciuyJvT7iHFn4vPRU8hOz-OZvZxyboFKrqWqv-CFARHLtgK0hPoUsw5-UEfUphMetQI-uhc7_XRuT4614Br-Fp6fV5f7OT7v5Wz5BV4fwL8KuNX8ElnF_zsfB-Sd0X3Mfxr_w8HWpHA</recordid><startdate>20080321</startdate><enddate>20080321</enddate><creator>Tan, Ge</creator><creator>Sun, Shan-quan</creator><creator>Yuan, Dong-li</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20080321</creationdate><title>Expression of Kir 4.1 in human astrocytic tumors: Correlation with pathologic grade</title><author>Tan, Ge ; Sun, Shan-quan ; Yuan, Dong-li</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-84fc1dab4689334bd9556ac34b7a861b792a3b769f536b7e5e907d40a255bb313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Astrocytic tumors</topic><topic>Astrocytoma - metabolism</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Brain Neoplasms - metabolism</topic><topic>Child</topic><topic>Female</topic><topic>Glia</topic><topic>Humans</topic><topic>Inward rectifying potassium channels</topic><topic>Kir 4.1</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Proteins - metabolism</topic><topic>Potassium Channels, Inwardly Rectifying - metabolism</topic><topic>Statistics as Topic</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tan, Ge</creatorcontrib><creatorcontrib>Sun, Shan-quan</creatorcontrib><creatorcontrib>Yuan, Dong-li</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tan, Ge</au><au>Sun, Shan-quan</au><au>Yuan, Dong-li</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of Kir 4.1 in human astrocytic tumors: Correlation with pathologic grade</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2008-03-21</date><risdate>2008</risdate><volume>367</volume><issue>4</issue><spage>743</spage><epage>747</epage><pages>743-747</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>Inward rectifying potassium channels (Kir), and in particular Kir 4.1, are key regulators of glial functions, which in turn determine neuronal excitability and axonal conduction. A high expression of Kir 4.1 has been detected in in some pathological conditions. In this study, we investigated the expression of Kir 4.1 mRNA and protein in 80 cases of human astrocytic tumors by reverse transcription polymerase chain reaction, Western blot and immunohistochemistry, respectively. The correlation between Kir 4.1 expression and pathologic grade of astrocytic tumors was further analyzed. The results showed that the expression of Kir 4.1 mRNA and protein, as well as the Kir 4.1 immunoreactivity score (IRS), increased markedly with increasing pathologic grade. Therefore, Kir 4.1 may be a new biomarker for astrocytic tumors. It may also be an attractive therapy target for human astrocytic tumors.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>18191638</pmid><doi>10.1016/j.bbrc.2008.01.014</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Astrocytic tumors Astrocytoma - metabolism Biomarkers, Tumor - metabolism Brain Neoplasms - metabolism Child Female Glia Humans Inward rectifying potassium channels Kir 4.1 Male Middle Aged Neoplasm Proteins - metabolism Potassium Channels, Inwardly Rectifying - metabolism Statistics as Topic Tumor Cells, Cultured |
| title | Expression of Kir 4.1 in human astrocytic tumors: Correlation with pathologic grade |
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