Lack of alternative coreceptor use by pediatric HIV-1 R5 isolates for infection of primary cord or adult peripheral blood mononuclear cells
HIV-1 infection of neonates results in an extended acute period of virus replication, frequent neurological problems and reduced survival compared to adults. In adults, R5 viruses mainly infect CCR5⁺ CD4⁺ memory T-cells. In neonates, CCR5⁺ memory T-cells form a substantially smaller fraction of tota...
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| Veröffentlicht in: | Archives of virology 2008-02, Vol.153 (2), p.363-366 |
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| creator | Sullivan, W. M Dorr, P Perros, M Hudson, R Leif, J Luzuriaga, K Clapham, P. R |
| description | HIV-1 infection of neonates results in an extended acute period of virus replication, frequent neurological problems and reduced survival compared to adults. In adults, R5 viruses mainly infect CCR5⁺ CD4⁺ memory T-cells. In neonates, CCR5⁺ memory T-cells form a substantially smaller fraction of total lymphocytes. We therefore tested whether alternative coreceptors confer infection of lymphocytes by pediatric isolates. Pediatric HIV-1 R5 isolates failed to replicate in Δ32/Δ32 CCR5 PBMCs or in cord PBMCs treated with a CCR5 inhibitor. These results do not indicate a role for alternative coreceptors and provide support for CCR5 inhibitors in the therapy of HIV-1⁺ neonates. |
| doi_str_mv | 10.1007/s00705-007-1099-6 |
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M ; Dorr, P ; Perros, M ; Hudson, R ; Leif, J ; Luzuriaga, K ; Clapham, P. R</creator><creatorcontrib>Sullivan, W. M ; Dorr, P ; Perros, M ; Hudson, R ; Leif, J ; Luzuriaga, K ; Clapham, P. R</creatorcontrib><description>HIV-1 infection of neonates results in an extended acute period of virus replication, frequent neurological problems and reduced survival compared to adults. In adults, R5 viruses mainly infect CCR5⁺ CD4⁺ memory T-cells. In neonates, CCR5⁺ memory T-cells form a substantially smaller fraction of total lymphocytes. We therefore tested whether alternative coreceptors confer infection of lymphocytes by pediatric isolates. Pediatric HIV-1 R5 isolates failed to replicate in Δ32/Δ32 CCR5 PBMCs or in cord PBMCs treated with a CCR5 inhibitor. These results do not indicate a role for alternative coreceptors and provide support for CCR5 inhibitors in the therapy of HIV-1⁺ neonates.</description><identifier>ISSN: 0304-8608</identifier><identifier>EISSN: 1432-8798</identifier><identifier>DOI: 10.1007/s00705-007-1099-6</identifier><identifier>PMID: 18074097</identifier><language>eng</language><publisher>Vienna: Vienna : Springer-Verlag</publisher><subject>Acquired immune deficiency syndrome ; Adults ; AIDS ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Brief Report ; CCR5 Receptor Antagonists ; Fundamental and applied biological sciences. 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M</creatorcontrib><creatorcontrib>Dorr, P</creatorcontrib><creatorcontrib>Perros, M</creatorcontrib><creatorcontrib>Hudson, R</creatorcontrib><creatorcontrib>Leif, J</creatorcontrib><creatorcontrib>Luzuriaga, K</creatorcontrib><creatorcontrib>Clapham, P. R</creatorcontrib><title>Lack of alternative coreceptor use by pediatric HIV-1 R5 isolates for infection of primary cord or adult peripheral blood mononuclear cells</title><title>Archives of virology</title><addtitle>Arch Virol</addtitle><addtitle>Arch Virol</addtitle><description>HIV-1 infection of neonates results in an extended acute period of virus replication, frequent neurological problems and reduced survival compared to adults. In adults, R5 viruses mainly infect CCR5⁺ CD4⁺ memory T-cells. In neonates, CCR5⁺ memory T-cells form a substantially smaller fraction of total lymphocytes. We therefore tested whether alternative coreceptors confer infection of lymphocytes by pediatric isolates. Pediatric HIV-1 R5 isolates failed to replicate in Δ32/Δ32 CCR5 PBMCs or in cord PBMCs treated with a CCR5 inhibitor. These results do not indicate a role for alternative coreceptors and provide support for CCR5 inhibitors in the therapy of HIV-1⁺ neonates.</description><subject>Acquired immune deficiency syndrome</subject><subject>Adults</subject><subject>AIDS</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brief Report</subject><subject>CCR5 Receptor Antagonists</subject><subject>Fundamental and applied biological sciences. 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| ispartof | Archives of virology, 2008-02, Vol.153 (2), p.363-366 |
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| subjects | Acquired immune deficiency syndrome Adults AIDS Biological and medical sciences Biomedical and Life Sciences Biomedicine Brief Report CCR5 Receptor Antagonists Fundamental and applied biological sciences. Psychology HIV HIV Infections - virology HIV Reverse Transcriptase - metabolism HIV-1 - physiology Human immunodeficiency virus Human immunodeficiency virus 1 Human viral diseases Humans Infant Infant, Newborn Infections Infectious Diseases Leukocytes, Mononuclear - virology Lymphocytes Medical Microbiology Medical schools Medical sciences Medicine Microbiology Miscellaneous Pediatrics Receptors, CCR5 - genetics Receptors, Virus - genetics Receptors, Virus - physiology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Virology Virus Internalization Virus Replication - physiology Viruses |
| title | Lack of alternative coreceptor use by pediatric HIV-1 R5 isolates for infection of primary cord or adult peripheral blood mononuclear cells |
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