Solution Structure and Interaction of Cupiennin 1a, a Spider Venom Peptide, with Phospholipid Bilayers

The solution structure of cupiennin 1a, a 35 residue, basic antibacterial peptide isolated from the venom of the spider Cupiennius salei, has been determined by nuclear magnetic resonance (NMR) spectroscopy. The peptide was found to adopt a helix−hinge−helix structure in a membrane mimicking solvent...

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Veröffentlicht in:	Biochemistry (Easton) 2007-03, Vol.46 (11), p.3576-3585
Hauptverfasser:	Pukala, Tara L, Boland, Martin P, Gehman, John D, Kuhn-Nentwig, Lucia, Separovic, Frances, Bowie, John H
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Araneae Cupiennius salei Dimyristoylphosphatidylcholine - chemistry Lipid Bilayers - chemistry Liposomes - chemistry Molecular Sequence Data Nuclear Magnetic Resonance, Biomolecular Peptides - chemistry Phosphatidylglycerols - chemistry Phosphorus Isotopes Spider Venoms - chemistry Spiders
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