Characterization of the potency, selectivity, and pharmacokinetic profile for six adenosine A2A receptor antagonists

Antagonists of adenosine A2A receptors (A2A -antagonists) with different chemical structures have been developed by several pharmaceutical companies for the potential treatment of Parkinson's disease. Pharmacological characterization of these antagonists was incomplete, and different assay cond...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 2007-04, Vol.375 (2), p.133-144
Hauptverfasser:	Yang, Ming, Soohoo, Daniel, Soelaiman, Sandriyana, Kalla, Rao, Zablocki, Jeff, Chu, Nancy, Leung, Kwan, Yao, Lina, Diamond, Ivan, Belardinelli, Luiz, Shryock, John C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - analogs & derivatives Adenosine - chemistry Adenosine - pharmacokinetics Adenosine - pharmacology Adenosine A2 Receptor Antagonists Adenosine A3 Receptor Antagonists Animals Binding, Competitive - drug effects Biological Availability Cell Line Cyclic AMP - metabolism Dose-Response Relationship, Drug Humans Male Metabolic Clearance Rate Molecular Structure PC12 Cells Phenethylamines - chemistry Phenethylamines - pharmacokinetics Phenethylamines - pharmacology Purines - chemistry Purines - pharmacokinetics Purines - pharmacology Pyrimidines - chemistry Pyrimidines - pharmacokinetics Pyrimidines - pharmacology Rats Rats, Sprague-Dawley Receptor, Adenosine A2A - genetics Receptor, Adenosine A3 - genetics Receptor, Adenosine A3 - metabolism Theobromine - analogs & derivatives Theobromine - chemistry Theobromine - pharmacokinetics Theobromine - pharmacology Triazines - chemistry Triazines - pharmacokinetics Triazines - pharmacology Triazoles - chemistry Triazoles - pharmacokinetics Triazoles - pharmacology Xanthines - chemistry Xanthines - pharmacokinetics Xanthines - pharmacology
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