Pharmacokinetics of Levobupivacaine, Fentanyl, and Clonidine After Administration in Thoracic Paravertebral Analgesia

There is little knowledge of the pharmacokinetics of local anesthetics and adjunctive analgesics after paravertebral blockade. We evaluated the pharmacokinetics of low-dose levobupivacaine, fentanyl, and clonidine after paravertebral analgesia for breast surgery. Thirty-eight patients receiving para...

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Veröffentlicht in:	Regional anesthesia and pain medicine 2007-03, Vol.32 (2), p.136-145
Hauptverfasser:	Burlacu, Crina L., Frizelle, Henry P., Moriarty, Denis C., Buggy, Donal J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analgesia Anesthetics, Local - blood Anesthetics, Local - pharmacokinetics Breast Neoplasms - surgery Bupivacaine - analogs & derivatives Bupivacaine - blood Bupivacaine - pharmacokinetics Clonidine Clonidine - blood Clonidine - pharmacokinetics Drug Administration Routes Female Fentanyl Fentanyl - blood Fentanyl - pharmacokinetics Humans Levobupivacaine Mass Spectrometry Middle Aged Pain, Postoperative - prevention & control Paravertebral Pharmacokinetics Regional anesthesia Thoracic Vertebrae - innervation
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