Progesterone supplementation during mid-gestation increases the risk of abortion in Neospora-infected dairy cows with high antibody titres
Progesterone has been reported to reduce Th1 responses during pregnancy. Thus, given that an excessive Th1 response could lead to abortion in Neospora-infected dairy cows, we hypothesized a reduction in abortion risk following progesterone supplementation during the mid-gestation period in these ani...
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| Veröffentlicht in: | Veterinary parasitology 2007-04, Vol.145 (1), p.164-167 |
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| creator | Bech-Sàbat, G. López-Gatius, F. Santolaria, P. García-Ispierto, I. Pabón, M. Nogareda, C. Yániz, J.L. Almería, S. |
| description | Progesterone has been reported to reduce Th1 responses during pregnancy. Thus, given that an excessive Th1 response could lead to abortion in
Neospora-infected dairy cows, we hypothesized a reduction in abortion risk following progesterone supplementation during the mid-gestation period in these animals. Seropositive animals were assigned on day 120 of gestation to a Control (
n
=
33) or Treatment (
n
=
34) group. Treatment consisted of progesterone supplementation by fitting a progesterone releasing intravaginal device containing 1.55
g of progesterone for 28 days. Mean
Neospora caninum antibody titres tested by ELISA on days 40, 90 and 120 of gestation were used to classify the cows as showing high (≥30 units) or low ( |
| doi_str_mv | 10.1016/j.vetpar.2006.11.018 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70257588</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0304401706006546</els_id><sourcerecordid>70257588</sourcerecordid><originalsourceid>FETCH-LOGICAL-c384t-764a800c68d5c1ebd7a991c03cd2b62ee32801b47cfe9fc1c43a31b988d97a3d3</originalsourceid><addsrcrecordid>eNp9kc-O1DAMxiMEYoeFN0CQE7cOdtM26QUJrfgnrQAJ9hyliTuTYdqUJN3VvAJPTUcdiRsnS_bvs-zvY-wlwhYBm7eH7T3lycRtCdBsEbeA6hHboJKiKOsaHrMNCKiKClBesWcpHQCggkY-ZVcoUZULuWF_vsewo5QphpF4mqfpSAON2WQfRu7m6McdH7wrztDa9KONZBIlnvfEo0-_eOi56UK8jPlXCmkK0RR-7MlmctwZH0_chofEH3ze873f7bkZs--CO_Hsc6T0nD3pzTHRi0u9ZncfP_y8-Vzcfvv05eb9bWGFqnIhm8ooANsoV1ukzknTtmhBWFd2TUkkSgXYVdL21PYWbSWMwK5VyrXSCCeu2Zt17xTD73l5Sw8-WToezUhhTlpCWctaqQWsVtDGkFKkXk_RDyaeNII-Z6APes1AnzPQiHrJYJG9uuyfu4HcP9HF9AV4vQK9CdrsFgf13Y8SUADIRjTYLsS7laDFh3tPUSfrabTkfFwM1S74_9_wFwHNp2g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70257588</pqid></control><display><type>article</type><title>Progesterone supplementation during mid-gestation increases the risk of abortion in Neospora-infected dairy cows with high antibody titres</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Bech-Sàbat, G. ; López-Gatius, F. ; Santolaria, P. ; García-Ispierto, I. ; Pabón, M. ; Nogareda, C. ; Yániz, J.L. ; Almería, S.</creator><creatorcontrib>Bech-Sàbat, G. ; López-Gatius, F. ; Santolaria, P. ; García-Ispierto, I. ; Pabón, M. ; Nogareda, C. ; Yániz, J.L. ; Almería, S.</creatorcontrib><description>Progesterone has been reported to reduce Th1 responses during pregnancy. Thus, given that an excessive Th1 response could lead to abortion in
Neospora-infected dairy cows, we hypothesized a reduction in abortion risk following progesterone supplementation during the mid-gestation period in these animals. Seropositive animals were assigned on day 120 of gestation to a Control (
n
=
33) or Treatment (
n
=
34) group. Treatment consisted of progesterone supplementation by fitting a progesterone releasing intravaginal device containing 1.55
g of progesterone for 28 days. Mean
Neospora caninum antibody titres tested by ELISA on days 40, 90 and 120 of gestation were used to classify the cows as showing high (≥30 units) or low (<30 units) titration. Abortion rate showed a significant increase (
P
<
0.01) in the Treatment group (35%) compared to the Control (9%). Using logistic regression procedures, there was a significant (
P
<
0.0001) interaction between progesterone treatment and antibody titration. Progesterone-treated cows with a high antibody titre showed a likelihood of abortion 14.3 times higher than those not treated, while in cows with low antibody titres, exogenous progesterone had not effect. Our results do not support our starting hypothesis and suggest that progesterone supplementation in cows with high
N. caninum antibody titres increases the risk of abortion possibly by affecting cell-mediated immune responses.</description><identifier>ISSN: 0304-4017</identifier><identifier>EISSN: 1873-2550</identifier><identifier>DOI: 10.1016/j.vetpar.2006.11.018</identifier><identifier>PMID: 17182187</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Abortion ; abortion (animals) ; abortion risk ; Abortion, Veterinary - etiology ; Animals ; Antibodies, Protozoan - blood ; antibody formation ; antibody titers ; Cattle ; Cattle Diseases - etiology ; Coccidiosis - complications ; Coccidiosis - veterinary ; Dairy cattle ; dairy cows ; Female ; hormone supplements ; Neospora - isolation & purification ; Neospora caninum ; neosporosis ; Pregnancy ; Pregnancy Complications, Parasitic - veterinary ; progesterone ; Progesterone - pharmacology ; Progesterone supplementation ; risk assessment ; seroprevalence</subject><ispartof>Veterinary parasitology, 2007-04, Vol.145 (1), p.164-167</ispartof><rights>2006 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-764a800c68d5c1ebd7a991c03cd2b62ee32801b47cfe9fc1c43a31b988d97a3d3</citedby><cites>FETCH-LOGICAL-c384t-764a800c68d5c1ebd7a991c03cd2b62ee32801b47cfe9fc1c43a31b988d97a3d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304401706006546$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17182187$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bech-Sàbat, G.</creatorcontrib><creatorcontrib>López-Gatius, F.</creatorcontrib><creatorcontrib>Santolaria, P.</creatorcontrib><creatorcontrib>García-Ispierto, I.</creatorcontrib><creatorcontrib>Pabón, M.</creatorcontrib><creatorcontrib>Nogareda, C.</creatorcontrib><creatorcontrib>Yániz, J.L.</creatorcontrib><creatorcontrib>Almería, S.</creatorcontrib><title>Progesterone supplementation during mid-gestation increases the risk of abortion in Neospora-infected dairy cows with high antibody titres</title><title>Veterinary parasitology</title><addtitle>Vet Parasitol</addtitle><description>Progesterone has been reported to reduce Th1 responses during pregnancy. Thus, given that an excessive Th1 response could lead to abortion in
Neospora-infected dairy cows, we hypothesized a reduction in abortion risk following progesterone supplementation during the mid-gestation period in these animals. Seropositive animals were assigned on day 120 of gestation to a Control (
n
=
33) or Treatment (
n
=
34) group. Treatment consisted of progesterone supplementation by fitting a progesterone releasing intravaginal device containing 1.55
g of progesterone for 28 days. Mean
Neospora caninum antibody titres tested by ELISA on days 40, 90 and 120 of gestation were used to classify the cows as showing high (≥30 units) or low (<30 units) titration. Abortion rate showed a significant increase (
P
<
0.01) in the Treatment group (35%) compared to the Control (9%). Using logistic regression procedures, there was a significant (
P
<
0.0001) interaction between progesterone treatment and antibody titration. Progesterone-treated cows with a high antibody titre showed a likelihood of abortion 14.3 times higher than those not treated, while in cows with low antibody titres, exogenous progesterone had not effect. Our results do not support our starting hypothesis and suggest that progesterone supplementation in cows with high
N. caninum antibody titres increases the risk of abortion possibly by affecting cell-mediated immune responses.</description><subject>Abortion</subject><subject>abortion (animals)</subject><subject>abortion risk</subject><subject>Abortion, Veterinary - etiology</subject><subject>Animals</subject><subject>Antibodies, Protozoan - blood</subject><subject>antibody formation</subject><subject>antibody titers</subject><subject>Cattle</subject><subject>Cattle Diseases - etiology</subject><subject>Coccidiosis - complications</subject><subject>Coccidiosis - veterinary</subject><subject>Dairy cattle</subject><subject>dairy cows</subject><subject>Female</subject><subject>hormone supplements</subject><subject>Neospora - isolation & purification</subject><subject>Neospora caninum</subject><subject>neosporosis</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Parasitic - veterinary</subject><subject>progesterone</subject><subject>Progesterone - pharmacology</subject><subject>Progesterone supplementation</subject><subject>risk assessment</subject><subject>seroprevalence</subject><issn>0304-4017</issn><issn>1873-2550</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc-O1DAMxiMEYoeFN0CQE7cOdtM26QUJrfgnrQAJ9hyliTuTYdqUJN3VvAJPTUcdiRsnS_bvs-zvY-wlwhYBm7eH7T3lycRtCdBsEbeA6hHboJKiKOsaHrMNCKiKClBesWcpHQCggkY-ZVcoUZULuWF_vsewo5QphpF4mqfpSAON2WQfRu7m6McdH7wrztDa9KONZBIlnvfEo0-_eOi56UK8jPlXCmkK0RR-7MlmctwZH0_chofEH3ze873f7bkZs--CO_Hsc6T0nD3pzTHRi0u9ZncfP_y8-Vzcfvv05eb9bWGFqnIhm8ooANsoV1ukzknTtmhBWFd2TUkkSgXYVdL21PYWbSWMwK5VyrXSCCeu2Zt17xTD73l5Sw8-WToezUhhTlpCWctaqQWsVtDGkFKkXk_RDyaeNII-Z6APes1AnzPQiHrJYJG9uuyfu4HcP9HF9AV4vQK9CdrsFgf13Y8SUADIRjTYLsS7laDFh3tPUSfrabTkfFwM1S74_9_wFwHNp2g</recordid><startdate>20070410</startdate><enddate>20070410</enddate><creator>Bech-Sàbat, G.</creator><creator>López-Gatius, F.</creator><creator>Santolaria, P.</creator><creator>García-Ispierto, I.</creator><creator>Pabón, M.</creator><creator>Nogareda, C.</creator><creator>Yániz, J.L.</creator><creator>Almería, S.</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070410</creationdate><title>Progesterone supplementation during mid-gestation increases the risk of abortion in Neospora-infected dairy cows with high antibody titres</title><author>Bech-Sàbat, G. ; López-Gatius, F. ; Santolaria, P. ; García-Ispierto, I. ; Pabón, M. ; Nogareda, C. ; Yániz, J.L. ; Almería, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-764a800c68d5c1ebd7a991c03cd2b62ee32801b47cfe9fc1c43a31b988d97a3d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Abortion</topic><topic>abortion (animals)</topic><topic>abortion risk</topic><topic>Abortion, Veterinary - etiology</topic><topic>Animals</topic><topic>Antibodies, Protozoan - blood</topic><topic>antibody formation</topic><topic>antibody titers</topic><topic>Cattle</topic><topic>Cattle Diseases - etiology</topic><topic>Coccidiosis - complications</topic><topic>Coccidiosis - veterinary</topic><topic>Dairy cattle</topic><topic>dairy cows</topic><topic>Female</topic><topic>hormone supplements</topic><topic>Neospora - isolation & purification</topic><topic>Neospora caninum</topic><topic>neosporosis</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Parasitic - veterinary</topic><topic>progesterone</topic><topic>Progesterone - pharmacology</topic><topic>Progesterone supplementation</topic><topic>risk assessment</topic><topic>seroprevalence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bech-Sàbat, G.</creatorcontrib><creatorcontrib>López-Gatius, F.</creatorcontrib><creatorcontrib>Santolaria, P.</creatorcontrib><creatorcontrib>García-Ispierto, I.</creatorcontrib><creatorcontrib>Pabón, M.</creatorcontrib><creatorcontrib>Nogareda, C.</creatorcontrib><creatorcontrib>Yániz, J.L.</creatorcontrib><creatorcontrib>Almería, S.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bech-Sàbat, G.</au><au>López-Gatius, F.</au><au>Santolaria, P.</au><au>García-Ispierto, I.</au><au>Pabón, M.</au><au>Nogareda, C.</au><au>Yániz, J.L.</au><au>Almería, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Progesterone supplementation during mid-gestation increases the risk of abortion in Neospora-infected dairy cows with high antibody titres</atitle><jtitle>Veterinary parasitology</jtitle><addtitle>Vet Parasitol</addtitle><date>2007-04-10</date><risdate>2007</risdate><volume>145</volume><issue>1</issue><spage>164</spage><epage>167</epage><pages>164-167</pages><issn>0304-4017</issn><eissn>1873-2550</eissn><abstract>Progesterone has been reported to reduce Th1 responses during pregnancy. Thus, given that an excessive Th1 response could lead to abortion in
Neospora-infected dairy cows, we hypothesized a reduction in abortion risk following progesterone supplementation during the mid-gestation period in these animals. Seropositive animals were assigned on day 120 of gestation to a Control (
n
=
33) or Treatment (
n
=
34) group. Treatment consisted of progesterone supplementation by fitting a progesterone releasing intravaginal device containing 1.55
g of progesterone for 28 days. Mean
Neospora caninum antibody titres tested by ELISA on days 40, 90 and 120 of gestation were used to classify the cows as showing high (≥30 units) or low (<30 units) titration. Abortion rate showed a significant increase (
P
<
0.01) in the Treatment group (35%) compared to the Control (9%). Using logistic regression procedures, there was a significant (
P
<
0.0001) interaction between progesterone treatment and antibody titration. Progesterone-treated cows with a high antibody titre showed a likelihood of abortion 14.3 times higher than those not treated, while in cows with low antibody titres, exogenous progesterone had not effect. Our results do not support our starting hypothesis and suggest that progesterone supplementation in cows with high
N. caninum antibody titres increases the risk of abortion possibly by affecting cell-mediated immune responses.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>17182187</pmid><doi>10.1016/j.vetpar.2006.11.018</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-4017 |
| ispartof | Veterinary parasitology, 2007-04, Vol.145 (1), p.164-167 |
| issn | 0304-4017 1873-2550 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70257588 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Abortion abortion (animals) abortion risk Abortion, Veterinary - etiology Animals Antibodies, Protozoan - blood antibody formation antibody titers Cattle Cattle Diseases - etiology Coccidiosis - complications Coccidiosis - veterinary Dairy cattle dairy cows Female hormone supplements Neospora - isolation & purification Neospora caninum neosporosis Pregnancy Pregnancy Complications, Parasitic - veterinary progesterone Progesterone - pharmacology Progesterone supplementation risk assessment seroprevalence |
| title | Progesterone supplementation during mid-gestation increases the risk of abortion in Neospora-infected dairy cows with high antibody titres |
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