An Nkx2-5/Bmp2/Smad1 Negative Feedback Loop Controls Heart Progenitor Specification and Proliferation

During heart development the second heart field (SHF) provides progenitor cells for most cardiomyocytes and expresses the homeodomain factor Nkx2-5. We now show that feedback repression of Bmp2/Smad1 signaling by Nkx2-5 critically regulates SHF proliferation and outflow tract (OFT) morphology. In th...

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Veröffentlicht in:	Cell 2007-03, Vol.128 (5), p.947-959
Hauptverfasser:	Prall, Owen W.J., Menon, Mary K., Solloway, Mark J., Watanabe, Yusuke, Zaffran, Stéphane, Bajolle, Fanny, Biben, Christine, McBride, Jim J., Robertson, Bronwyn R., Chaulet, Hervé, Stennard, Fiona A., Wise, Natalie, Schaft, Daniel, Wolstein, Orit, Furtado, Milena B., Shiratori, Hidetaka, Chien, Kenneth R., Hamada, Hiroshi, Black, Brian L., Saga, Yumiko, Robertson, Elizabeth J., Buckingham, Margaret E., Harvey, Richard P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Morphogenetic Protein 2 Bone Morphogenetic Proteins - metabolism Cell Proliferation DNA, Complementary Embryo, Mammalian Feedback, Physiological Heart - embryology Heart Defects, Congenital - genetics Heart Defects, Congenital - metabolism Homeobox Protein Nkx-2.5 Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans LIM-Homeodomain Proteins Mice Multipotent Stem Cells - cytology Multipotent Stem Cells - metabolism Myocardium - cytology Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism Oligonucleotide Array Sequence Analysis Phenotype Smad1 Protein - metabolism Transcription Factors - genetics Transcription Factors - metabolism Transforming Growth Factor beta - metabolism
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