Structural and Biochemical Studies of ALIX/AIP1 and Its Role in Retrovirus Budding

ALIX/AIP1 functions in enveloped virus budding, endosomal protein sorting, and many other cellular processes. Retroviruses, including HIV-1, SIV, and EIAV, bind and recruit ALIX through YPX nL late-domain motifs (X = any residue; n = 1–3). Crystal structures reveal that human ALIX is composed of an...

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Veröffentlicht in:	Cell 2007-03, Vol.128 (5), p.841-852
Hauptverfasser:	Fisher, Robert D., Chung, Hyo-Young, Zhai, Qianting, Robinson, Howard, Sundquist, Wesley I., Hill, Christopher P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Calcium-Binding Proteins - chemistry Calcium-Binding Proteins - metabolism Carrier Proteins - chemistry Carrier Proteins - metabolism Cell Cycle Proteins - chemistry Cell Cycle Proteins - metabolism Cell Line Crystallography, X-Ray Endosomal Sorting Complexes Required for Transport Endosomes - metabolism gag Gene Products, Human Immunodeficiency Virus Gene Products, gag - metabolism Glycoproteins - metabolism HeLa Cells HIV-1 - chemistry HIV-1 - drug effects HIV-1 - growth & development HIV-1 - metabolism Humans Infectious Anemia Virus, Equine - chemistry Infectious Anemia Virus, Equine - growth & development Infectious Anemia Virus, Equine - metabolism Models, Molecular Mutation Protein Structure, Tertiary Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - metabolism Viral Envelope Proteins - metabolism
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