C-terminal splice variants of the μ-opioid receptor: existence, distribution and functional characteristics

The distribution of the mRNA of different C-terminal splice variants of the μ-opioid receptor in rat CNS was assessed by RT-PCR. The mRNA species for MOR1, MOR1A and MOR1B were readily detectable and distributed widely throughout the rat CNS, with levels of MOR1 and MOR1A mRNA being overall greater...

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Veröffentlicht in:	Journal of neurochemistry 2008-02, Vol.104 (4), p.937-945
Hauptverfasser:	Oldfield, Sue, Braksator, Ellen, Rodriguez-Martin, Ivan, Bailey, Chris P, Donaldson, Lucy F, Henderson, Graeme, Kelly, Eamonn
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Analgesics, Opioid - pharmacology Animals Cell Line Central Nervous System - chemistry Central Nervous System - drug effects Central Nervous System - physiology Enkephalin, Ala-MePhe-Gly- - pharmacology G-protein-coupled receptor Humans Male Molecular Sequence Data Peptide Fragments - agonists Peptide Fragments - analysis Peptide Fragments - physiology Protein Isoforms - agonists Protein Isoforms - analysis Protein Isoforms - physiology Rats Rats, Wistar Receptors, Opioid, mu - agonists Receptors, Opioid, mu - analysis Receptors, Opioid, mu - physiology splice variant μ-opioid receptor
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