Alterations in the testis of hormone sensitive lipase-deficient mice is associated with decreased sperm counts, sperm motility, and fertility

Hormone‐sensitive lipase (HSL, Lipe, E.C.3.1.1.3) functions as a triglyceride and cholesteryl esterase, supplying fatty acids, and cholesterol to cells. Gene‐targeted HSL‐deficient (HSL−/−) mice reveal abnormal spermatids and are infertile at 24 weeks after birth. The purpose of this study was to fo...

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Veröffentlicht in:	Molecular reproduction and development 2008-04, Vol.75 (4), p.565-577
Hauptverfasser:	Hermo, Louis, Chung, Shari, Gregory, Mary, Smith, Charles E., Wang, Shu Pei, El-Alfy, Mohamed, Cyr, Daniel G., Mitchell, Grant A., Trasler, Jacquetta
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences cholesteryl esterases Disease Progression Fundamental and applied biological sciences. Psychology gene-targeting Hormone metabolism and regulation hormone-sensitive lipase HSL in situ hybridization Infertility, Male - enzymology Infertility, Male - pathology Male Mammalian male genital system Mice Mice, Inbred BALB C Mice, Knockout Sperm Count Sperm Motility spermatids Spermatids - pathology Spermatozoa - pathology Sterol Esterase - deficiency Sterol Esterase - genetics testis Testis - enzymology Testis - pathology Vertebrates: reproduction
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