Molecular Definition of Breast Tumor Heterogeneity

Cells with distinct phenotypes including stem-cell-like properties have been proposed to exist in normal human mammary epithelium and breast carcinomas, but their detailed molecular characteristics and clinical significance are unclear. We determined gene expression and genetic profiles of cells pur...

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Veröffentlicht in:	Cancer cell 2007-03, Vol.11 (3), p.259-273
Hauptverfasser:	Shipitsin, Michail, Campbell, Lauren L., Argani, Pedram, Weremowicz, Stanislawa, Bloushtain-Qimron, Noga, Yao, Jun, Nikolskaya, Tatiana, Serebryiskaya, Tatiana, Beroukhim, Rameen, Hu, Min, Halushka, Marc K., Sukumar, Saraswati, Parker, Leroy M., Anderson, Karen S., Harris, Lyndsay N., Garber, Judy E., Richardson, Andrea L., Schnitt, Stuart J., Nikolsky, Yuri, Gelman, Rebecca S., Polyak, Kornelia
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - metabolism Biomarkers, Tumor - metabolism Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Carcinoma, Ductal, Breast - genetics Carcinoma, Ductal, Breast - metabolism Carcinoma, Ductal, Breast - pathology CD24 Antigen - metabolism Cell Lineage CELLCYCLE Cells, Cultured Endothelial Protein C Receptor Female Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Hyaluronan Receptors - metabolism Mammary Glands, Human - metabolism Mammary Glands, Human - pathology Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Pregnancy Receptors, Cell Surface - metabolism Signal Transduction Stem Cells - metabolism Stem Cells - pathology Transforming Growth Factor beta - metabolism
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