Beneficial properties for insulin absorption using superporous hydrogel containing interpenetrating polymer network as oral delivery vehicles

In this investigation, superporous hydrogels containing poly (acrylic acid- co-acrylamide)/ O-carboxymethyl chitosan ( O-CMC) full-interpenetrating polymer networks (SPH-IPNs) were evaluated for their potentials in effective insulin absorption via the oral route. Insulin release from the SPH-IPNs ex...

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Veröffentlicht in:	International journal of pharmaceutics 2008-02, Vol.350 (1), p.220-229
Hauptverfasser:	Yin, Lichen, Ding, JieYing, Fei, Likun, He, Miao, Cui, Fuying, Tang, Cui, Yin, Chunhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Biological and medical sciences Calcium - chemistry Chitosan - administration & dosage Chitosan - analogs & derivatives Chymotrypsin - antagonists & inhibitors Copper - chemistry Drug Stability Enzymatic inhibition General pharmacology Hydrogel, Polyethylene Glycol Dimethacrylate - administration & dosage Hydrogen-Ion Concentration Insulin Insulin - administration & dosage Insulin - chemistry Insulin - pharmacokinetics Intestinal Absorption Male Medical sciences Muco-adhesion Oral administration Osmolar Concentration Pharmaceutical technology. Pharmaceutical industry Pharmaceutical Vehicles Pharmacology. Drug treatments Porosity Protein Conformation Rats Rats, Sprague-Dawley Solubility Superporous hydrogels containing full-interpenetrating polymer networks Transport enhancement Trypsin Inhibitors - pharmacology
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