Thymic development and peripheral homeostasis of regulatory T cells
The development and maintenance of regulatory T (T-reg) cells is crucial for determining the level of reactivity in the immune system. Until recently, however, surprisingly little was known about the factors involved in the development of these cells in the thymus or the mechanisms that maintain the...
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| Veröffentlicht in: | Current Opinion in Immunology 2007-04, Vol.19 (2), p.176-185 |
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| creator | Liston, Adrian Rudensky, Alexander Y |
| description | The development and maintenance of regulatory T (T-reg) cells is crucial for determining the level of reactivity in the immune system. Until recently, however, surprisingly little was known about the factors involved in the development of these cells in the thymus or the mechanisms that maintain them in the periphery. Studies have now demonstrated that thymic development of T-reg cells is facilitated by TCRs with increased affinity for self-peptide–MHC complexes. Increased TCR affinity alone, however, is not sufficient to support the development of T-reg cells, and external factors such as CD80 and CD86, ligands for co-stimulatory receptor CD28, and interleukin 2 are required. These factors are also needed to maintain the T-reg cell subset in the periphery. |
| doi_str_mv | 10.1016/j.coi.2007.02.005 |
| format | Article |
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These factors are also needed to maintain the T-reg cell subset in the periphery.</description><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Cytokines - metabolism</subject><subject>Homeostasis</subject><subject>Mice</subject><subject>Receptors, Antigen, T-Cell - analysis</subject><subject>Receptors, Antigen, T-Cell - metabolism</subject><subject>Signal Transduction</subject><subject>T-Lymphocytes, Regulatory - chemistry</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><subject>Thymus Gland - growth & development</subject><subject>Thymus Gland - immunology</subject><issn>0952-7915</issn><issn>1879-0372</issn><issn>1365-2567</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks2r1DAUxYMovvHpH-BGunLXem_aNA2CIINf8MCF4zqkya2TsV8m7YP571_KDAgu1FU2v3NyOecw9hKhQMD6zamwky84gCyAFwDiEdthI1UOpeSP2Q6U4LlUKG7YsxhPkAhRwlN2g7KEWnDYsf3heB68zRzdUz_NA41LZkaXzRT8fKRg-uw4DTTFxUQfs6nLAv1Ye7NM4ZwdMkt9H5-zJ53pI724vrfs-8cPh_3n_O7rpy_793e5FYhL3hopO6MaQl6qVrauJawFdsZVAF2lSqw7h65W1tl0NLSNMW1VV6pTtnKNK2_Z64vvHKZfK8VFDz5uF5iRpjVqCVyAUuKfIAeJkD79D7BELniTQLyANkwxBur0HPxgwlkj6K0LfdKpC711oYHrlHTSvLqar-1A7rfiGn4C3l4ASqHdewo6Wk-jJecD2UW7ZPg3-3d_qG3vR29N_5POFE_TGsbUhkYdk0B_28awbQFk2gGWWD4A6guucQ</recordid><startdate>20070401</startdate><enddate>20070401</enddate><creator>Liston, Adrian</creator><creator>Rudensky, Alexander Y</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20070401</creationdate><title>Thymic development and peripheral homeostasis of regulatory T cells</title><author>Liston, Adrian ; Rudensky, Alexander Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-ba77fa98e1239b7bdbe1651fad400f49316fd1d69cdc7910b8aab4649f9c4d8d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>Cytokines - metabolism</topic><topic>Homeostasis</topic><topic>Mice</topic><topic>Receptors, Antigen, T-Cell - analysis</topic><topic>Receptors, Antigen, T-Cell - metabolism</topic><topic>Signal Transduction</topic><topic>T-Lymphocytes, Regulatory - chemistry</topic><topic>T-Lymphocytes, Regulatory - immunology</topic><topic>Thymus Gland - growth & development</topic><topic>Thymus Gland - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liston, Adrian</creatorcontrib><creatorcontrib>Rudensky, Alexander Y</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Current Opinion in Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liston, Adrian</au><au>Rudensky, Alexander Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thymic development and peripheral homeostasis of regulatory T cells</atitle><jtitle>Current Opinion in Immunology</jtitle><addtitle>Curr Opin Immunol</addtitle><date>2007-04-01</date><risdate>2007</risdate><volume>19</volume><issue>2</issue><spage>176</spage><epage>185</epage><pages>176-185</pages><issn>0952-7915</issn><eissn>1879-0372</eissn><eissn>1365-2567</eissn><abstract>The development and maintenance of regulatory T (T-reg) cells is crucial for determining the level of reactivity in the immune system. 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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content; IngentaConnect Free/Open Access Journals; PubMed Central |
| subjects | Allergy and Immunology Animals Cytokines - metabolism Homeostasis Mice Receptors, Antigen, T-Cell - analysis Receptors, Antigen, T-Cell - metabolism Signal Transduction T-Lymphocytes, Regulatory - chemistry T-Lymphocytes, Regulatory - immunology Thymus Gland - growth & development Thymus Gland - immunology |
| title | Thymic development and peripheral homeostasis of regulatory T cells |
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