Regulation of ovarian angiogenesis and apoptosis by GnRH-I analogs

An adequate vascular supply is important to provide endocrine and paracrine signals during follicular development. We evaluated the direct in vivo effects of both the GnRH‐agonist Leuprolide acetate (LA) and the GnRH‐antagonist Antide (Ant) on the expression of VEGF‐A and ANPT‐1 and their receptors...

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Veröffentlicht in:	Molecular reproduction and development 2008-04, Vol.75 (4), p.623-631
Hauptverfasser:	Parborell, Fernanda, Irusta, Griselda, Rodríguez Celín, Alejandra, Tesone, Marta
Format:	Artikel
Sprache:	eng
Schlagworte:	angiogenesis Angiopoietin-1 - antagonists & inhibitors Angiopoietin-1 - biosynthesis Animals apoptosis Apoptosis - drug effects Apoptosis - physiology Biological and medical sciences Caspase 3 - drug effects Caspase 3 - metabolism Enzyme Activation - drug effects Female Fundamental and applied biological sciences. Psychology GnRH-I analogs Gonadotropin-Releasing Hormone - analogs & derivatives Gonadotropin-Releasing Hormone - pharmacology Hormone metabolism and regulation Injections, Subcutaneous Leuprolide - administration & dosage Mammalian female genital system Neovascularization, Physiologic - drug effects Neovascularization, Physiologic - physiology Oligopeptides - administration & dosage Ovarian Follicle - cytology Ovarian Follicle - drug effects Ovarian Follicle - metabolism ovary Ovary - blood supply Ovary - cytology Ovary - drug effects Rats Rats, Sprague-Dawley Receptor, TIE-2 - biosynthesis Receptor, TIE-2 - drug effects Structure-Activity Relationship Vascular Endothelial Growth Factor A - biosynthesis Vascular Endothelial Growth Factor A - drug effects Vascular Endothelial Growth Factor Receptor-2 - biosynthesis Vascular Endothelial Growth Factor Receptor-2 - drug effects Vertebrates: reproduction
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