RORα in genetic control of cerebellum development: 50 staggering years
Abstract The staggerer mutation was first identified at the Jackson Laboratory in 1955. In the ensuing half-century, studies of staggerer mice have provided new insights into developmental neurobiology, gene regulatory networks, and circadian behavior. Recent work has expanded the role of RORα, the...
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| Veröffentlicht in: | Brain research 2007-04, Vol.1140, p.19-25 |
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| creator | Gold, David A Gent, Peter M Hamilton, Bruce A |
| description | Abstract The staggerer mutation was first identified at the Jackson Laboratory in 1955. In the ensuing half-century, studies of staggerer mice have provided new insights into developmental neurobiology, gene regulatory networks, and circadian behavior. Recent work has expanded the role of RORα, the transcription factor mutated in staggerer , to peripheral tissues, including cholesterol and lipid metabolism, immune function, and bone development. This review focuses on the role of RORα in neural development and behavior revealed by the staggerer mutation and subsequent molecular studies. |
| doi_str_mv | 10.1016/j.brainres.2005.11.080 |
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This review focuses on the role of RORα in neural development and behavior revealed by the staggerer mutation and subsequent molecular studies.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/j.brainres.2005.11.080</identifier><identifier>PMID: 16427031</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Animals ; Behavior, Animal - physiology ; Biological and medical sciences ; Cerebellum - cytology ; Cerebellum - growth & development ; Cerebellum - metabolism ; Circadian Rhythm - genetics ; Development. Senescence. Regeneration. Transplantation ; Fundamental and applied biological sciences. Psychology ; History, 20th Century ; Mice ; Mice, Neurologic Mutants - genetics ; Motor Activity - genetics ; Neurology ; Nuclear Receptor Subfamily 1, Group F, Member 1 ; Orphan nuclear receptor ; Purkinje cell ; Receptors, Cytoplasmic and Nuclear - metabolism ; Reciprocal signaling ; staggerer ; Trans-Activators - metabolism ; Transcriptional control ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research, 2007-04, Vol.1140, p.19-25</ispartof><rights>Elsevier B.V.</rights><rights>2005 Elsevier B.V.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-ad3a7db9937a8d1ad8a8a1a21688f0a18d06a38900babbe79a65c4c6c38b23a93</citedby><cites>FETCH-LOGICAL-c482t-ad3a7db9937a8d1ad8a8a1a21688f0a18d06a38900babbe79a65c4c6c38b23a93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.brainres.2005.11.080$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18616626$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16427031$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gold, David A</creatorcontrib><creatorcontrib>Gent, Peter M</creatorcontrib><creatorcontrib>Hamilton, Bruce A</creatorcontrib><title>RORα in genetic control of cerebellum development: 50 staggering years</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Abstract The staggerer mutation was first identified at the Jackson Laboratory in 1955. 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Senescence. Regeneration. Transplantation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>History, 20th Century</topic><topic>Mice</topic><topic>Mice, Neurologic Mutants - genetics</topic><topic>Motor Activity - genetics</topic><topic>Neurology</topic><topic>Nuclear Receptor Subfamily 1, Group F, Member 1</topic><topic>Orphan nuclear receptor</topic><topic>Purkinje cell</topic><topic>Receptors, Cytoplasmic and Nuclear - metabolism</topic><topic>Reciprocal signaling</topic><topic>staggerer</topic><topic>Trans-Activators - metabolism</topic><topic>Transcriptional control</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gold, David A</creatorcontrib><creatorcontrib>Gent, Peter M</creatorcontrib><creatorcontrib>Hamilton, Bruce A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gold, David A</au><au>Gent, Peter M</au><au>Hamilton, Bruce A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>RORα in genetic control of cerebellum development: 50 staggering years</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2007-04-06</date><risdate>2007</risdate><volume>1140</volume><spage>19</spage><epage>25</epage><pages>19-25</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Abstract The staggerer mutation was first identified at the Jackson Laboratory in 1955. 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| ispartof | Brain research, 2007-04, Vol.1140, p.19-25 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Behavior, Animal - physiology Biological and medical sciences Cerebellum - cytology Cerebellum - growth & development Cerebellum - metabolism Circadian Rhythm - genetics Development. Senescence. Regeneration. Transplantation Fundamental and applied biological sciences. Psychology History, 20th Century Mice Mice, Neurologic Mutants - genetics Motor Activity - genetics Neurology Nuclear Receptor Subfamily 1, Group F, Member 1 Orphan nuclear receptor Purkinje cell Receptors, Cytoplasmic and Nuclear - metabolism Reciprocal signaling staggerer Trans-Activators - metabolism Transcriptional control Vertebrates: nervous system and sense organs |
| title | RORα in genetic control of cerebellum development: 50 staggering years |
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