Synthesis of some bioactive 2-bromo-5-methoxy- N′-[4-(aryl)-1,3-thiazol-2-yl]benzohydrazide derivatives
Eight novel 2-bromo-5-methoxy- N′-[4-(aryl)-1,3-thiazol-2-yl]benzohydrazide derivatives were prepared and characterized by analytical and spectral analyses. All the compounds were screened for their analgesic, antifungal and antibacterial activities and three of the compounds were screened for antip...
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| Veröffentlicht in: | European journal of medicinal chemistry 2007-03, Vol.42 (3), p.425-429 |
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| container_title | European journal of medicinal chemistry |
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| creator | Vijaya Raj, K.K. Narayana, B. Ashalatha, B.V. Suchetha Kumari, N. Sarojini, B.K. |
| description | Eight novel 2-bromo-5-methoxy-
N′-[4-(aryl)-1,3-thiazol-2-yl]benzohydrazide derivatives were prepared and characterized by analytical and spectral analyses. All the compounds were screened for their analgesic, antifungal and antibacterial activities and three of the compounds were screened for antiproliferative activity. Two of the newly synthesized compounds exhibited promising analgesic activity and one compound exhibited in vitro antiproliferative activity.
Eight novel 2-bromo-5-methoxy-
N′-[4-(aryl)-1,3-thiazol-2-yl]benzohydrazide derivatives were prepared and characterized by analytical and spectral methods. The compounds were screened for their analgesic, antiproliferative, antifungal and antibacterial activities. Compound
3a displayed some analgesic, antiproliferative and antifungal activities.
[Display omitted] |
| doi_str_mv | 10.1016/j.ejmech.2006.09.010 |
| format | Article |
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N′-[4-(aryl)-1,3-thiazol-2-yl]benzohydrazide derivatives were prepared and characterized by analytical and spectral analyses. All the compounds were screened for their analgesic, antifungal and antibacterial activities and three of the compounds were screened for antiproliferative activity. Two of the newly synthesized compounds exhibited promising analgesic activity and one compound exhibited in vitro antiproliferative activity.
Eight novel 2-bromo-5-methoxy-
N′-[4-(aryl)-1,3-thiazol-2-yl]benzohydrazide derivatives were prepared and characterized by analytical and spectral methods. The compounds were screened for their analgesic, antiproliferative, antifungal and antibacterial activities. Compound
3a displayed some analgesic, antiproliferative and antifungal activities.
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N′-[4-(aryl)-1,3-thiazol-2-yl]benzohydrazide derivatives were prepared and characterized by analytical and spectral analyses. All the compounds were screened for their analgesic, antifungal and antibacterial activities and three of the compounds were screened for antiproliferative activity. Two of the newly synthesized compounds exhibited promising analgesic activity and one compound exhibited in vitro antiproliferative activity.
Eight novel 2-bromo-5-methoxy-
N′-[4-(aryl)-1,3-thiazol-2-yl]benzohydrazide derivatives were prepared and characterized by analytical and spectral methods. The compounds were screened for their analgesic, antiproliferative, antifungal and antibacterial activities. Compound
3a displayed some analgesic, antiproliferative and antifungal activities.
[Display omitted]</description><subject>2-Bromo-5-methoxy</subject><subject>Analgesics</subject><subject>Analgesics, Non-Narcotic - chemical synthesis</subject><subject>Analgesics, Non-Narcotic - pharmacology</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - chemical synthesis</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antifungal Agents - chemical synthesis</subject><subject>Antifungal Agents - pharmacology</subject><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents - chemical synthesis</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Bacteria - drug effects</subject><subject>Bioactive</subject><subject>Biological and medical sciences</subject><subject>Cell Line, Tumor</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Female</subject><subject>Fungi - drug effects</subject><subject>General aspects</subject><subject>Humans</subject><subject>Hydrazines - chemical synthesis</subject><subject>Hydrazines - pharmacology</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Microbial Sensitivity Tests</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Synthesis</subject><subject>Thiazoles - chemical synthesis</subject><subject>Thiazoles - pharmacology</subject><subject>Thiazolylbenzohydrazide</subject><issn>0223-5234</issn><issn>1768-3254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM2K1EAUhQtRnHb0DUSycVCw4q1KVdK1EYbBn4FBF-pKpKifG1JNkhqr0o3plc_kI_kkpumG2c3qbr5zOPcj5DmDkgGr325K3AzoupID1CWoEhg8ICvW1GtacSkekhVwXlHJK3FGnuS8AQBZAzwmZ6yBRgjOVyR8ncepwxxyEdsixwELG6JxU9hhwalNcYhU0gGnLv6eafH535-_9Iegr0ya-9eUvano1AWzjz3ldO5_Whz3sZt9MvvgsfCYws4cyvJT8qg1fcZnp3tOvn94_-3qE7358vH66vKGukrBRBuoHLJGWG5UJZxtJQprmW-xVlI1awu8Uq3iwjccvODW-UWAr9dOcSuNqM7JxbH3NsVfW8yTHkJ22PdmxLjNugEuQUq5gOIIuhRzTtjq2xSG5S_NQB8U640-KtYHxRqUXhQvsRen_q0d0N-FTk4X4OUJMNmZvk1mdCHfcWupFDC1cO-OHC42dgGTzi7g6NCHhG7SPob7l_wHLZGb4w</recordid><startdate>20070301</startdate><enddate>20070301</enddate><creator>Vijaya Raj, K.K.</creator><creator>Narayana, B.</creator><creator>Ashalatha, B.V.</creator><creator>Suchetha Kumari, N.</creator><creator>Sarojini, B.K.</creator><general>Elsevier Masson SAS</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070301</creationdate><title>Synthesis of some bioactive 2-bromo-5-methoxy- N′-[4-(aryl)-1,3-thiazol-2-yl]benzohydrazide derivatives</title><author>Vijaya Raj, K.K. ; Narayana, B. ; Ashalatha, B.V. ; Suchetha Kumari, N. ; Sarojini, B.K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-703ce174b2a934cbf5e4bb1dfe695978b0239f924d720d42bcd200d68c92b5a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>2-Bromo-5-methoxy</topic><topic>Analgesics</topic><topic>Analgesics, Non-Narcotic - chemical synthesis</topic><topic>Analgesics, Non-Narcotic - pharmacology</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - chemical synthesis</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antifungal Agents - chemical synthesis</topic><topic>Antifungal Agents - pharmacology</topic><topic>Antineoplastic agents</topic><topic>Antineoplastic Agents - chemical synthesis</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Bacteria - drug effects</topic><topic>Bioactive</topic><topic>Biological and medical sciences</topic><topic>Cell Line, Tumor</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Female</topic><topic>Fungi - drug effects</topic><topic>General aspects</topic><topic>Humans</topic><topic>Hydrazines - chemical synthesis</topic><topic>Hydrazines - pharmacology</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Microbial Sensitivity Tests</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Synthesis</topic><topic>Thiazoles - chemical synthesis</topic><topic>Thiazoles - pharmacology</topic><topic>Thiazolylbenzohydrazide</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vijaya Raj, K.K.</creatorcontrib><creatorcontrib>Narayana, B.</creatorcontrib><creatorcontrib>Ashalatha, B.V.</creatorcontrib><creatorcontrib>Suchetha Kumari, N.</creatorcontrib><creatorcontrib>Sarojini, B.K.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vijaya Raj, K.K.</au><au>Narayana, B.</au><au>Ashalatha, B.V.</au><au>Suchetha Kumari, N.</au><au>Sarojini, B.K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis of some bioactive 2-bromo-5-methoxy- N′-[4-(aryl)-1,3-thiazol-2-yl]benzohydrazide derivatives</atitle><jtitle>European journal of medicinal chemistry</jtitle><addtitle>Eur J Med Chem</addtitle><date>2007-03-01</date><risdate>2007</risdate><volume>42</volume><issue>3</issue><spage>425</spage><epage>429</epage><pages>425-429</pages><issn>0223-5234</issn><eissn>1768-3254</eissn><coden>EJMCA5</coden><abstract>Eight novel 2-bromo-5-methoxy-
N′-[4-(aryl)-1,3-thiazol-2-yl]benzohydrazide derivatives were prepared and characterized by analytical and spectral analyses. All the compounds were screened for their analgesic, antifungal and antibacterial activities and three of the compounds were screened for antiproliferative activity. Two of the newly synthesized compounds exhibited promising analgesic activity and one compound exhibited in vitro antiproliferative activity.
Eight novel 2-bromo-5-methoxy-
N′-[4-(aryl)-1,3-thiazol-2-yl]benzohydrazide derivatives were prepared and characterized by analytical and spectral methods. The compounds were screened for their analgesic, antiproliferative, antifungal and antibacterial activities. Compound
3a displayed some analgesic, antiproliferative and antifungal activities.
[Display omitted]</abstract><cop>Oxford</cop><pub>Elsevier Masson SAS</pub><pmid>17074422</pmid><doi>10.1016/j.ejmech.2006.09.010</doi><tpages>5</tpages></addata></record> |
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| issn | 0223-5234 1768-3254 |
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| subjects | 2-Bromo-5-methoxy Analgesics Analgesics, Non-Narcotic - chemical synthesis Analgesics, Non-Narcotic - pharmacology Animals Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal Agents - chemical synthesis Antifungal Agents - pharmacology Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Bacteria - drug effects Bioactive Biological and medical sciences Cell Line, Tumor Drug Screening Assays, Antitumor Female Fungi - drug effects General aspects Humans Hydrazines - chemical synthesis Hydrazines - pharmacology Magnetic Resonance Spectroscopy Male Medical sciences Mice Microbial Sensitivity Tests Neuropharmacology Pharmacology. Drug treatments Synthesis Thiazoles - chemical synthesis Thiazoles - pharmacology Thiazolylbenzohydrazide |
| title | Synthesis of some bioactive 2-bromo-5-methoxy- N′-[4-(aryl)-1,3-thiazol-2-yl]benzohydrazide derivatives |
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