Steric Tuning of Silylacetylenes and Chiral Phosphine Ligands for Rhodium-Catalyzed Asymmetric Conjugate Alkynylation of Enones
Rhodium-catalyzed asymmetric conjugate alkynylation of α,β-unsaturated ketones giving β-alkynylketones took place in high yields with high enantioselectivity. The reaction was realized by use of (triisopropylsilyl)acetylene combined with (R)-DTBM-segphos as a chiral phosphine ligand, where the steri...
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| Veröffentlicht in: | Journal of the American Chemical Society 2008-02, Vol.130 (5), p.1576-1577 |
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| container_end_page | 1577 |
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| container_issue | 5 |
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| container_title | Journal of the American Chemical Society |
| container_volume | 130 |
| creator | Nishimura, Takahiro Guo, Xun-Xiang Uchiyama, Nanase Katoh, Taisuke Hayashi, Tamio |
| description | Rhodium-catalyzed asymmetric conjugate alkynylation of α,β-unsaturated ketones giving β-alkynylketones took place in high yields with high enantioselectivity. The reaction was realized by use of (triisopropylsilyl)acetylene combined with (R)-DTBM-segphos as a chiral phosphine ligand, where the sterically bulky substituents on the silicon and phosphorus atoms suppress the alkyne dimerization. |
| doi_str_mv | 10.1021/ja710540s |
| format | Article |
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| source | ACS Publications |
| title | Steric Tuning of Silylacetylenes and Chiral Phosphine Ligands for Rhodium-Catalyzed Asymmetric Conjugate Alkynylation of Enones |
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