Postsurgical Health‐related Quality of Life (HRQOL) in Children Following Hemispherectomy for Intractable Epilepsy
Health‐related quality of life (HRQOL) is an important outcome measure in clinical research. Given the psychosocial and behavioral difficulties associated with pediatric epilepsy, evaluating HRQOL in this patient population is of particular importance. Though HRQOL has been examined in pediatric pat...
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| Veröffentlicht in: | Epilepsia (Copenhagen) 2007-03, Vol.48 (3), p.564-570 |
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| creator | Griffiths, Stephanie Y. Sherman, Elisabeth M. S. Slick, Daniel J. Eyrl, Kim Connolly, Mary B. Steinbok, Paul |
| description | Health‐related quality of life (HRQOL) is an important outcome measure in clinical research. Given the psychosocial and behavioral difficulties associated with pediatric epilepsy, evaluating HRQOL in this patient population is of particular importance. Though HRQOL has been examined in pediatric patients receiving focal resection or pharmacological (antiepileptic drug; AED) treatment, it has not been assessed in patients receiving hemispherectomy (HE) for intractable epilepsy. The current study evaluated HRQOL in a sample of pediatric HE cases (N = 26) using previously validated questionnaires relative to surgical (N = 30) and nonsurgical (N = 84) comparison groups. Compared with focal resection and nonsurgical patients, parents of children who received HE reported similar levels of HRQOL. In surgical cases, worse HRQOL was correlated with residual seizure frequency. In both surgical and nonsurgical cases, female gender, higher AED load, and lower functional independence predicted worse HRQOL. Interestingly, HE status (i.e., having undergone HE) predicted fewer epilepsy‐related limitations. Consistent with previous findings, AED load, in addition to lower functional abilities, appear particularly detrimental to life quality in pediatric epilepsy. HE, however, is not associated with increased risk for poor HRQOL. When considered in light of the multiple, significant risk factors for poor outcome associated with HE, children who undergo the procedure fare surprisingly well. |
| doi_str_mv | 10.1111/j.1528-1167.2006.00966.x |
| format | Article |
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S. ; Slick, Daniel J. ; Eyrl, Kim ; Connolly, Mary B. ; Steinbok, Paul</creator><creatorcontrib>Griffiths, Stephanie Y. ; Sherman, Elisabeth M. S. ; Slick, Daniel J. ; Eyrl, Kim ; Connolly, Mary B. ; Steinbok, Paul</creatorcontrib><description>Health‐related quality of life (HRQOL) is an important outcome measure in clinical research. Given the psychosocial and behavioral difficulties associated with pediatric epilepsy, evaluating HRQOL in this patient population is of particular importance. Though HRQOL has been examined in pediatric patients receiving focal resection or pharmacological (antiepileptic drug; AED) treatment, it has not been assessed in patients receiving hemispherectomy (HE) for intractable epilepsy. The current study evaluated HRQOL in a sample of pediatric HE cases (N = 26) using previously validated questionnaires relative to surgical (N = 30) and nonsurgical (N = 84) comparison groups. Compared with focal resection and nonsurgical patients, parents of children who received HE reported similar levels of HRQOL. In surgical cases, worse HRQOL was correlated with residual seizure frequency. In both surgical and nonsurgical cases, female gender, higher AED load, and lower functional independence predicted worse HRQOL. Interestingly, HE status (i.e., having undergone HE) predicted fewer epilepsy‐related limitations. Consistent with previous findings, AED load, in addition to lower functional abilities, appear particularly detrimental to life quality in pediatric epilepsy. HE, however, is not associated with increased risk for poor HRQOL. When considered in light of the multiple, significant risk factors for poor outcome associated with HE, children who undergo the procedure fare surprisingly well.</description><identifier>ISSN: 0013-9580</identifier><identifier>EISSN: 1528-1167</identifier><identifier>DOI: 10.1111/j.1528-1167.2006.00966.x</identifier><identifier>PMID: 17284297</identifier><identifier>CODEN: EPILAK</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>Activities of Daily Living ; Adolescent ; Age Factors ; Anticonvulsants - administration & dosage ; Anticonvulsants. Antiepileptics. Antiparkinson agents ; Biological and medical sciences ; Child ; Disability Evaluation ; Epilepsy - drug therapy ; Epilepsy - psychology ; Epilepsy - surgery ; Female ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Health Status ; Health‐related quality of life ; Hemispherectomy ; Hemispherectomy - methods ; Humans ; Intractable epilepsy ; Male ; Medical sciences ; Nervous system (semeiology, syndromes) ; Neurology ; Neuropharmacology ; Neurosurgery ; Parents - psychology ; Pharmacology. Drug treatments ; Postoperative Period ; Postsurgical ; Quality of Life ; Risk Factors ; Sex Factors ; Skull, brain, vascular surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. 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S.</creatorcontrib><creatorcontrib>Slick, Daniel J.</creatorcontrib><creatorcontrib>Eyrl, Kim</creatorcontrib><creatorcontrib>Connolly, Mary B.</creatorcontrib><creatorcontrib>Steinbok, Paul</creatorcontrib><title>Postsurgical Health‐related Quality of Life (HRQOL) in Children Following Hemispherectomy for Intractable Epilepsy</title><title>Epilepsia (Copenhagen)</title><addtitle>Epilepsia</addtitle><description>Health‐related quality of life (HRQOL) is an important outcome measure in clinical research. Given the psychosocial and behavioral difficulties associated with pediatric epilepsy, evaluating HRQOL in this patient population is of particular importance. Though HRQOL has been examined in pediatric patients receiving focal resection or pharmacological (antiepileptic drug; AED) treatment, it has not been assessed in patients receiving hemispherectomy (HE) for intractable epilepsy. The current study evaluated HRQOL in a sample of pediatric HE cases (N = 26) using previously validated questionnaires relative to surgical (N = 30) and nonsurgical (N = 84) comparison groups. Compared with focal resection and nonsurgical patients, parents of children who received HE reported similar levels of HRQOL. In surgical cases, worse HRQOL was correlated with residual seizure frequency. In both surgical and nonsurgical cases, female gender, higher AED load, and lower functional independence predicted worse HRQOL. Interestingly, HE status (i.e., having undergone HE) predicted fewer epilepsy‐related limitations. Consistent with previous findings, AED load, in addition to lower functional abilities, appear particularly detrimental to life quality in pediatric epilepsy. HE, however, is not associated with increased risk for poor HRQOL. When considered in light of the multiple, significant risk factors for poor outcome associated with HE, children who undergo the procedure fare surprisingly well.</description><subject>Activities of Daily Living</subject><subject>Adolescent</subject><subject>Age Factors</subject><subject>Anticonvulsants - administration & dosage</subject><subject>Anticonvulsants. Antiepileptics. Antiparkinson agents</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Disability Evaluation</subject><subject>Epilepsy - drug therapy</subject><subject>Epilepsy - psychology</subject><subject>Epilepsy - surgery</subject><subject>Female</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Health Status</subject><subject>Health‐related quality of life</subject><subject>Hemispherectomy</subject><subject>Hemispherectomy - methods</subject><subject>Humans</subject><subject>Intractable epilepsy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Neuropharmacology</subject><subject>Neurosurgery</subject><subject>Parents - psychology</subject><subject>Pharmacology. Drug treatments</subject><subject>Postoperative Period</subject><subject>Postsurgical</subject><subject>Quality of Life</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>Skull, brain, vascular surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surveys and Questionnaires</subject><subject>Treatment Outcome</subject><subject>Wechsler Scales</subject><issn>0013-9580</issn><issn>1528-1167</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkN9u0zAUhy0EYmXwCsg3ILhI8J_EdiRupqqjlSptQ7u3nMReXblxsB1tueMReEaeBJdW7Bbf2NL5fj7nfABAjEqcz5d9iWsiCowZLwlCrESoYax8egEW_wovwQIhTIumFugCvIlxjxDijNPX4AJzIirS8AVItz6mOIUH2ykH11q5tPv981fQTiXdw7tJOZtm6A3cWqPhp_X3u5vtZ2gHuNxZ1wc9wGvvnH-0w0OOH2wcdzroLvnDDI0PcDOkoLqkWqfharROj3F-C14Z5aJ-d74vwf316n65LrY33zbLq23R0bxOobFuUW8oJqZiXdsT3jbEYERayhXvec0Mr2vOcVuLzigumGk5YYS2DKGK0Evw8fTtGPyPScck83iddk4N2k9RckQq0ZAqg-IEdsHHGLSRY7AHFWaJkTwKl3t59CqPXuVRuPwrXD7l6Ptzj6k96P45eDacgQ9nQMWs2AQ1dDY-c4LRWogmc19P3GN2NP_3AHJ1u8kP-gfR4p0e</recordid><startdate>200703</startdate><enddate>200703</enddate><creator>Griffiths, Stephanie Y.</creator><creator>Sherman, Elisabeth M. S.</creator><creator>Slick, Daniel J.</creator><creator>Eyrl, Kim</creator><creator>Connolly, Mary B.</creator><creator>Steinbok, Paul</creator><general>Blackwell Publishing Inc</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200703</creationdate><title>Postsurgical Health‐related Quality of Life (HRQOL) in Children Following Hemispherectomy for Intractable Epilepsy</title><author>Griffiths, Stephanie Y. ; Sherman, Elisabeth M. S. ; Slick, Daniel J. ; Eyrl, Kim ; Connolly, Mary B. ; Steinbok, Paul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3966-e1eb0df312f46cbd27b92f102b37a7d756f755771b58cfa786fb72623b600423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Activities of Daily Living</topic><topic>Adolescent</topic><topic>Age Factors</topic><topic>Anticonvulsants - administration & dosage</topic><topic>Anticonvulsants. Antiepileptics. Antiparkinson agents</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Disability Evaluation</topic><topic>Epilepsy - drug therapy</topic><topic>Epilepsy - psychology</topic><topic>Epilepsy - surgery</topic><topic>Female</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Health Status</topic><topic>Health‐related quality of life</topic><topic>Hemispherectomy</topic><topic>Hemispherectomy - methods</topic><topic>Humans</topic><topic>Intractable epilepsy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Neuropharmacology</topic><topic>Neurosurgery</topic><topic>Parents - psychology</topic><topic>Pharmacology. Drug treatments</topic><topic>Postoperative Period</topic><topic>Postsurgical</topic><topic>Quality of Life</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><topic>Skull, brain, vascular surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surveys and Questionnaires</topic><topic>Treatment Outcome</topic><topic>Wechsler Scales</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Griffiths, Stephanie Y.</creatorcontrib><creatorcontrib>Sherman, Elisabeth M. S.</creatorcontrib><creatorcontrib>Slick, Daniel J.</creatorcontrib><creatorcontrib>Eyrl, Kim</creatorcontrib><creatorcontrib>Connolly, Mary B.</creatorcontrib><creatorcontrib>Steinbok, Paul</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Epilepsia (Copenhagen)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Griffiths, Stephanie Y.</au><au>Sherman, Elisabeth M. S.</au><au>Slick, Daniel J.</au><au>Eyrl, Kim</au><au>Connolly, Mary B.</au><au>Steinbok, Paul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Postsurgical Health‐related Quality of Life (HRQOL) in Children Following Hemispherectomy for Intractable Epilepsy</atitle><jtitle>Epilepsia (Copenhagen)</jtitle><addtitle>Epilepsia</addtitle><date>2007-03</date><risdate>2007</risdate><volume>48</volume><issue>3</issue><spage>564</spage><epage>570</epage><pages>564-570</pages><issn>0013-9580</issn><eissn>1528-1167</eissn><coden>EPILAK</coden><abstract>Health‐related quality of life (HRQOL) is an important outcome measure in clinical research. Given the psychosocial and behavioral difficulties associated with pediatric epilepsy, evaluating HRQOL in this patient population is of particular importance. Though HRQOL has been examined in pediatric patients receiving focal resection or pharmacological (antiepileptic drug; AED) treatment, it has not been assessed in patients receiving hemispherectomy (HE) for intractable epilepsy. The current study evaluated HRQOL in a sample of pediatric HE cases (N = 26) using previously validated questionnaires relative to surgical (N = 30) and nonsurgical (N = 84) comparison groups. Compared with focal resection and nonsurgical patients, parents of children who received HE reported similar levels of HRQOL. In surgical cases, worse HRQOL was correlated with residual seizure frequency. In both surgical and nonsurgical cases, female gender, higher AED load, and lower functional independence predicted worse HRQOL. Interestingly, HE status (i.e., having undergone HE) predicted fewer epilepsy‐related limitations. Consistent with previous findings, AED load, in addition to lower functional abilities, appear particularly detrimental to life quality in pediatric epilepsy. HE, however, is not associated with increased risk for poor HRQOL. When considered in light of the multiple, significant risk factors for poor outcome associated with HE, children who undergo the procedure fare surprisingly well.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>17284297</pmid><doi>10.1111/j.1528-1167.2006.00966.x</doi><tpages>7</tpages></addata></record> |
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| ispartof | Epilepsia (Copenhagen), 2007-03, Vol.48 (3), p.564-570 |
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| subjects | Activities of Daily Living Adolescent Age Factors Anticonvulsants - administration & dosage Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Child Disability Evaluation Epilepsy - drug therapy Epilepsy - psychology Epilepsy - surgery Female Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Health Status Health‐related quality of life Hemispherectomy Hemispherectomy - methods Humans Intractable epilepsy Male Medical sciences Nervous system (semeiology, syndromes) Neurology Neuropharmacology Neurosurgery Parents - psychology Pharmacology. Drug treatments Postoperative Period Postsurgical Quality of Life Risk Factors Sex Factors Skull, brain, vascular surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surveys and Questionnaires Treatment Outcome Wechsler Scales |
| title | Postsurgical Health‐related Quality of Life (HRQOL) in Children Following Hemispherectomy for Intractable Epilepsy |
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