AX+/BX- Discrimination Learning in the Fear-Potentiated Startle Paradigm in Monkeys
Individuals with anxiety disorders often do not respond to safety signals and hence continue to be afraid and anxious. Consequently, it is important to develop paradigms in animals that can directly study brain systems involved in learning about, and responding to, safety signals. We previously deve...
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| Veröffentlicht in: | Learning & memory (Cold Spring Harbor, N.Y.) N.Y.), 2008-02, Vol.15 (2), p.63-66 |
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| container_title | Learning & memory (Cold Spring Harbor, N.Y.) |
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| creator | Winslow, James T Noble, Pamela L Davis, Michael |
| description | Individuals with anxiety disorders often do not respond to safety signals and hence continue to be afraid and anxious. Consequently, it is important to develop paradigms in animals that can directly study brain systems involved in learning about, and responding to, safety signals. We previously developed a discrimination procedure in rats of the form AX+/BX-, where cues A and X presented together are paired with an aversive stimulus and cues B and X presented together predict the absence of an aversive stimulus. The present experiment adapted this procedure to the fear-potentiated startle paradigm in rhesus monkeys. |
| doi_str_mv | 10.1101/lm.843308 |
| format | Article |
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| subjects | Acoustic Stimulation Air Animals Anxiety Association Learning - physiology Avoidance Learning - physiology Behavioral psychophysiology Biological and medical sciences Brain Conditioning (Psychology) - physiology Cues Discrimination Learning Discrimination Learning - physiology Fear Fear - physiology Fundamental and applied biological sciences. Psychology Learning Processes Macaca mulatta Male Photic Stimulation Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Reflex, Startle - physiology Safety Stimuli Touch |
| title | AX+/BX- Discrimination Learning in the Fear-Potentiated Startle Paradigm in Monkeys |
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