Rhabdoid Tumor Growth is Inhibited by Flavopiridol

Purpose: Rhabdoid tumors are aggressive and incurable pediatric malignancies. INI1/hSNF5, a tumor suppressor biallelically deleted/inactivated in rhabdoid tumors, directly represses cyclin D1. Rhabdoid tumors and cells are exquisitely dependent on cyclin D1 for genesis and survival, suggesting that...

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Veröffentlicht in:	Clinical cancer research 2008-01, Vol.14 (2), p.523-532
Hauptverfasser:	SMITH, Melissa E, CIMICA, Velasco, CHINNI, Srinivasa, CHALLAGULLA, Kavitha, MANI, Sridhar, KALPANA, Ganjam V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - pharmacology Apoptosis - drug effects Biological and medical sciences Caspases - metabolism Cell Line, Tumor Cell Proliferation - drug effects Cyclin D1 Cyclin D1 - metabolism Cyclin-Dependent Kinase Inhibitor p21 - metabolism Cyclin-Dependent Kinases - metabolism Drug Screening Assays, Antitumor Flavonoids - pharmacology Flavopiridol Humans Medical sciences Mice Mice, SCID Neoplasm Transplantation p21 Pharmacology. Drug treatments Piperidines - pharmacology Protein Kinase Inhibitors - pharmacology Rhabdoid Rhabdoid Tumor - drug therapy Rhabdoid Tumor - enzymology Rhabdoid Tumor - metabolism Rhabdoid Tumor - pathology Xenograft Model Antitumor Assays
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