A comparative treatment study of topical tacrolimus and clobetasol in oral lichen planus
Background Existing clinical trials have shown that topical corticosteroids are often effective in the management of oral lichen planus (OLP). However, tacrolimus has recently been shown to be an effective treatment of OLP. Objective To compare the effectiveness of clobetasol and tacrolimus in the t...
Gespeichert in:
| Veröffentlicht in: | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 2008-02, Vol.105 (2), p.187-193 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 193 |
|---|---|
| container_issue | 2 |
| container_start_page | 187 |
| container_title | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics |
| container_volume | 105 |
| creator | Radfar, Lida, DDS, MS Wild, Robert C., MS Suresh, Lakshmanan, BDS, MS |
| description | Background Existing clinical trials have shown that topical corticosteroids are often effective in the management of oral lichen planus (OLP). However, tacrolimus has recently been shown to be an effective treatment of OLP. Objective To compare the effectiveness of clobetasol and tacrolimus in the topical management of OLP. Study design In this randomized comparative double-blind study, 30 consecutive patients with oral lesions consistent clinically and histologically with OLP were recruited.The patients were divided into 2 groups to receive clobetasol 0.05% or tacrolimus 0.1% ointment and were treated for 6 weeks. Results The profiles of mean lesion sizes and mean pain measures did not differ between the tacrolimus and clobetasol treatment groups. Conclusion We found tacrolimus to be as useful as clobetasol in treatment of OLP. We believe that up-to-date evidence indicates the effectiveness of tacrolimus in treating OLP. |
| doi_str_mv | 10.1016/j.tripleo.2007.07.029 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70246982</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S1079210407006002</els_id><sourcerecordid>70246982</sourcerecordid><originalsourceid>FETCH-LOGICAL-c514t-aea45339d3fcd46da2dc48b0c20389ba6faf0578e3d3f75d48643659f6b1bec53</originalsourceid><addsrcrecordid>eNqFkU1rFTEUhoNYbHv1JyjZ2N3c5mMyM9kopWgrFFyo0F3IJGcw18xkTDKF--_NcAeFboRAsnjOyXueg9BbSvaU0Ob6sM_RzR7CnhHS7tfD5At0QQXrKi7F48vyJq2sGCX1ObpM6UAIabiUr9A57RgnvJMX6PEGmzDOOursngDnCDqPMGWc8mKPOAw4h9kZ7XHWJgbvxiVhPVlsfOgh6xQ8dhMOsRDemZ8w4dnraUmv0dmgfYI3271DPz5_-n57Xz18vftye_NQGUHrXGnQteBcWj4YWzdWM2vqrieGrfl63Qx6IKLtgBeiFbbumpo3Qg5NT3swgu_Q1anvHMPvBVJWo0sGfAkBYUmqJaxuZJl3h8QJLGOkFGFQc3SjjkdFiVqVqoPalKpVqVoPk6Xu3fbB0o9g_1VtDgvwfgN0KqKGqCfj0l-u9Go6IWjhPp44KDqeHESVjIPJgHURTFY2uP9G-fCsg_FuWrfzC46QDmGJU3GtqEpMEfVt3f-6ftKWDIQw_gdf_a3S</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70246982</pqid></control><display><type>article</type><title>A comparative treatment study of topical tacrolimus and clobetasol in oral lichen planus</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Radfar, Lida, DDS, MS ; Wild, Robert C., MS ; Suresh, Lakshmanan, BDS, MS</creator><creatorcontrib>Radfar, Lida, DDS, MS ; Wild, Robert C., MS ; Suresh, Lakshmanan, BDS, MS</creatorcontrib><description>Background Existing clinical trials have shown that topical corticosteroids are often effective in the management of oral lichen planus (OLP). However, tacrolimus has recently been shown to be an effective treatment of OLP. Objective To compare the effectiveness of clobetasol and tacrolimus in the topical management of OLP. Study design In this randomized comparative double-blind study, 30 consecutive patients with oral lesions consistent clinically and histologically with OLP were recruited.The patients were divided into 2 groups to receive clobetasol 0.05% or tacrolimus 0.1% ointment and were treated for 6 weeks. Results The profiles of mean lesion sizes and mean pain measures did not differ between the tacrolimus and clobetasol treatment groups. Conclusion We found tacrolimus to be as useful as clobetasol in treatment of OLP. We believe that up-to-date evidence indicates the effectiveness of tacrolimus in treating OLP.</description><identifier>ISSN: 1079-2104</identifier><identifier>EISSN: 1528-395X</identifier><identifier>DOI: 10.1016/j.tripleo.2007.07.029</identifier><identifier>PMID: 18230389</identifier><language>eng</language><publisher>St. Louis, MO: Mosby, Inc</publisher><subject>Administration, Topical ; Adult ; Aged ; Anti-Inflammatory Agents - administration & dosage ; Biological and medical sciences ; Clobetasol - administration & dosage ; Dentistry ; Dermatology ; Double-Blind Method ; Female ; Humans ; Immunosuppressive Agents - administration & dosage ; Lichen Planus, Oral - drug therapy ; Male ; Medical sciences ; Middle Aged ; Ointments ; Otorhinolaryngology. Stomatology ; Psoriasis. Parapsoriasis. Lichen ; Surgery ; Tacrolimus - administration & dosage ; Treatment Outcome</subject><ispartof>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics, 2008-02, Vol.105 (2), p.187-193</ispartof><rights>Mosby, Inc.</rights><rights>2008 Mosby, Inc.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c514t-aea45339d3fcd46da2dc48b0c20389ba6faf0578e3d3f75d48643659f6b1bec53</citedby><cites>FETCH-LOGICAL-c514t-aea45339d3fcd46da2dc48b0c20389ba6faf0578e3d3f75d48643659f6b1bec53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.tripleo.2007.07.029$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20068551$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18230389$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Radfar, Lida, DDS, MS</creatorcontrib><creatorcontrib>Wild, Robert C., MS</creatorcontrib><creatorcontrib>Suresh, Lakshmanan, BDS, MS</creatorcontrib><title>A comparative treatment study of topical tacrolimus and clobetasol in oral lichen planus</title><title>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics</title><addtitle>Oral Surg Oral Med Oral Pathol Oral Radiol Endod</addtitle><description>Background Existing clinical trials have shown that topical corticosteroids are often effective in the management of oral lichen planus (OLP). However, tacrolimus has recently been shown to be an effective treatment of OLP. Objective To compare the effectiveness of clobetasol and tacrolimus in the topical management of OLP. Study design In this randomized comparative double-blind study, 30 consecutive patients with oral lesions consistent clinically and histologically with OLP were recruited.The patients were divided into 2 groups to receive clobetasol 0.05% or tacrolimus 0.1% ointment and were treated for 6 weeks. Results The profiles of mean lesion sizes and mean pain measures did not differ between the tacrolimus and clobetasol treatment groups. Conclusion We found tacrolimus to be as useful as clobetasol in treatment of OLP. We believe that up-to-date evidence indicates the effectiveness of tacrolimus in treating OLP.</description><subject>Administration, Topical</subject><subject>Adult</subject><subject>Aged</subject><subject>Anti-Inflammatory Agents - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Clobetasol - administration & dosage</subject><subject>Dentistry</subject><subject>Dermatology</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Immunosuppressive Agents - administration & dosage</subject><subject>Lichen Planus, Oral - drug therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Ointments</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Psoriasis. Parapsoriasis. Lichen</subject><subject>Surgery</subject><subject>Tacrolimus - administration & dosage</subject><subject>Treatment Outcome</subject><issn>1079-2104</issn><issn>1528-395X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rFTEUhoNYbHv1JyjZ2N3c5mMyM9kopWgrFFyo0F3IJGcw18xkTDKF--_NcAeFboRAsnjOyXueg9BbSvaU0Ob6sM_RzR7CnhHS7tfD5At0QQXrKi7F48vyJq2sGCX1ObpM6UAIabiUr9A57RgnvJMX6PEGmzDOOursngDnCDqPMGWc8mKPOAw4h9kZ7XHWJgbvxiVhPVlsfOgh6xQ8dhMOsRDemZ8w4dnraUmv0dmgfYI3271DPz5_-n57Xz18vftye_NQGUHrXGnQteBcWj4YWzdWM2vqrieGrfl63Qx6IKLtgBeiFbbumpo3Qg5NT3swgu_Q1anvHMPvBVJWo0sGfAkBYUmqJaxuZJl3h8QJLGOkFGFQc3SjjkdFiVqVqoPalKpVqVoPk6Xu3fbB0o9g_1VtDgvwfgN0KqKGqCfj0l-u9Go6IWjhPp44KDqeHESVjIPJgHURTFY2uP9G-fCsg_FuWrfzC46QDmGJU3GtqEpMEfVt3f-6ftKWDIQw_gdf_a3S</recordid><startdate>20080201</startdate><enddate>20080201</enddate><creator>Radfar, Lida, DDS, MS</creator><creator>Wild, Robert C., MS</creator><creator>Suresh, Lakshmanan, BDS, MS</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080201</creationdate><title>A comparative treatment study of topical tacrolimus and clobetasol in oral lichen planus</title><author>Radfar, Lida, DDS, MS ; Wild, Robert C., MS ; Suresh, Lakshmanan, BDS, MS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c514t-aea45339d3fcd46da2dc48b0c20389ba6faf0578e3d3f75d48643659f6b1bec53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Administration, Topical</topic><topic>Adult</topic><topic>Aged</topic><topic>Anti-Inflammatory Agents - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Clobetasol - administration & dosage</topic><topic>Dentistry</topic><topic>Dermatology</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>Immunosuppressive Agents - administration & dosage</topic><topic>Lichen Planus, Oral - drug therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Ointments</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Psoriasis. Parapsoriasis. Lichen</topic><topic>Surgery</topic><topic>Tacrolimus - administration & dosage</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Radfar, Lida, DDS, MS</creatorcontrib><creatorcontrib>Wild, Robert C., MS</creatorcontrib><creatorcontrib>Suresh, Lakshmanan, BDS, MS</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Radfar, Lida, DDS, MS</au><au>Wild, Robert C., MS</au><au>Suresh, Lakshmanan, BDS, MS</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A comparative treatment study of topical tacrolimus and clobetasol in oral lichen planus</atitle><jtitle>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics</jtitle><addtitle>Oral Surg Oral Med Oral Pathol Oral Radiol Endod</addtitle><date>2008-02-01</date><risdate>2008</risdate><volume>105</volume><issue>2</issue><spage>187</spage><epage>193</epage><pages>187-193</pages><issn>1079-2104</issn><eissn>1528-395X</eissn><abstract>Background Existing clinical trials have shown that topical corticosteroids are often effective in the management of oral lichen planus (OLP). However, tacrolimus has recently been shown to be an effective treatment of OLP. Objective To compare the effectiveness of clobetasol and tacrolimus in the topical management of OLP. Study design In this randomized comparative double-blind study, 30 consecutive patients with oral lesions consistent clinically and histologically with OLP were recruited.The patients were divided into 2 groups to receive clobetasol 0.05% or tacrolimus 0.1% ointment and were treated for 6 weeks. Results The profiles of mean lesion sizes and mean pain measures did not differ between the tacrolimus and clobetasol treatment groups. Conclusion We found tacrolimus to be as useful as clobetasol in treatment of OLP. We believe that up-to-date evidence indicates the effectiveness of tacrolimus in treating OLP.</abstract><cop>St. Louis, MO</cop><pub>Mosby, Inc</pub><pmid>18230389</pmid><doi>10.1016/j.tripleo.2007.07.029</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1079-2104 |
| ispartof | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics, 2008-02, Vol.105 (2), p.187-193 |
| issn | 1079-2104 1528-395X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70246982 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Administration, Topical Adult Aged Anti-Inflammatory Agents - administration & dosage Biological and medical sciences Clobetasol - administration & dosage Dentistry Dermatology Double-Blind Method Female Humans Immunosuppressive Agents - administration & dosage Lichen Planus, Oral - drug therapy Male Medical sciences Middle Aged Ointments Otorhinolaryngology. Stomatology Psoriasis. Parapsoriasis. Lichen Surgery Tacrolimus - administration & dosage Treatment Outcome |
| title | A comparative treatment study of topical tacrolimus and clobetasol in oral lichen planus |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T07%3A32%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20comparative%20treatment%20study%20of%20topical%20tacrolimus%20and%20clobetasol%20in%20oral%20lichen%20planus&rft.jtitle=Oral%20surgery,%20oral%20medicine,%20oral%20pathology,%20oral%20radiology%20and%20endodontics&rft.au=Radfar,%20Lida,%20DDS,%20MS&rft.date=2008-02-01&rft.volume=105&rft.issue=2&rft.spage=187&rft.epage=193&rft.pages=187-193&rft.issn=1079-2104&rft.eissn=1528-395X&rft_id=info:doi/10.1016/j.tripleo.2007.07.029&rft_dat=%3Cproquest_cross%3E70246982%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70246982&rft_id=info:pmid/18230389&rft_els_id=1_s2_0_S1079210407006002&rfr_iscdi=true |