ADMA/DDAH pathway is a critical regulator of endothelial cell motility

Asymmetric dimethylarginine (ADMA) is an inhibitor of nitric oxide production associated with abnormal blood vessel growth and repair, however, the mechanism of action of ADMA is not well understood. We studied the role of exogenous and endogenous ADMA in the regulation of cell motility and actin cy...

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Veröffentlicht in:	Journal of cell science 2007-03, Vol.120 (6), p.929-942
Hauptverfasser:	Wojciak-Stothard, Beata, Torondel, Belen, Tsang, Lillian Yen Fen, Fleming, Ingrid, Fisslthaler, Beate, Leiper, James M, Vallance, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cytoskeleton - drug effects Actin Cytoskeleton - physiology Amidohydrolases - genetics Amidohydrolases - metabolism Animals Arginine - analogs & derivatives Arginine - pharmacology Arginine - physiology cdc42 GTP-Binding Protein - metabolism Cell Movement - drug effects Cell Movement - physiology Cells, Cultured Cyclic GMP - analogs & derivatives Cyclic GMP - pharmacology Cyclic GMP-Dependent Protein Kinases - metabolism Cytoskeleton - drug effects Cytoskeleton - physiology Endothelial Cells - drug effects Endothelial Cells - physiology Enzyme Activation Focal Adhesions - physiology Lung - blood supply Lung - cytology Mice Mice, Knockout Neovascularization, Physiologic - drug effects rac1 GTP-Binding Protein - metabolism rhoA GTP-Binding Protein - metabolism rhoB GTP-Binding Protein - metabolism Signal Transduction Stress Fibers - physiology Swine
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