Interaction between zonal populations of articular chondrocytes suppresses chondrocyte mineralization and this process is mediated by PTHrP

Summary Objective Articular cartilage is separated from subchondral bone by the tidemark and a calcified cartilage zone. Advancement of the calcified region and tidemark duplication are both hallmarks of osteoarthritis (OA). Currently the mechanisms controlling post-natal articular cartilage mineral...

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Veröffentlicht in:	Osteoarthritis and cartilage 2008-01, Vol.16 (1), p.70-82
Hauptverfasser:	Jiang, J., M.S, Leong, N.L., B.S, Mung, J.C., M.S, Hidaka, C., M.D, Lu, H.H., Ph.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - metabolism Alkaline phosphatase activity Animals Articular cartilage Calcification Cartilage, Articular - drug effects Cartilage, Articular - metabolism Cattle Chondrocytes Chondrocytes - drug effects Chondrocytes - metabolism Co-culture Coculture Techniques Collagen Type X - metabolism Hedgehog Proteins - metabolism Indian hedgehog Matrix Metalloproteinase 13 - metabolism Parathyroid hormone-related peptide Parathyroid Hormone-Related Protein - metabolism Parathyroid Hormone-Related Protein - pharmacology Rheumatology Triiodothyronine - pharmacology
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