Detection of extra-cellular enzymes of anaerobic gram-negative bacteria from clinically diseased and healthy sites
Anaerobic gram-negative bacteria (AGNB) produce enzymes that play a significant role in the development of disease. We tested 50 AGNB isolates, 25 each from clinically diseased and healthy human sites for in vitro production of caseinase, collagenase, etc. Majority of the isolates were Bacteroides f...
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| Veröffentlicht in: | Indian journal of medical microbiology 2008-01, Vol.26 (1), p.65-67 |
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| container_title | Indian journal of medical microbiology |
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| creator | Nagmoti, JM Patil, CS Nagmoti, MB Mutnal, MB |
| description | Anaerobic gram-negative bacteria (AGNB) produce enzymes that play a
significant role in the development of disease. We tested 50 AGNB
isolates, 25 each from clinically diseased and healthy human sites for
in vitro production of caseinase, collagenase, etc. Majority of the
isolates were Bacteroides fragilis and Porphyromonas gingivalis ,
which more commonly produced collagenase and haemolysin. Comparatively
larger number of clinical AGNB produced collagenase (P = 0.004). No
such difference was observed with other enzymes. Hence, collagenase is
probably one of the key virulence markers of pathogenic AGNB, and the
inhibitors targeting collagenases might help in the therapy of
anaerobic infections. |
| doi_str_mv | 10.1016/S0255-0857(21)01996-4 |
| format | Article |
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significant role in the development of disease. We tested 50 AGNB
isolates, 25 each from clinically diseased and healthy human sites for
in vitro production of caseinase, collagenase, etc. Majority of the
isolates were Bacteroides fragilis and Porphyromonas gingivalis ,
which more commonly produced collagenase and haemolysin. Comparatively
larger number of clinical AGNB produced collagenase (P = 0.004). No
such difference was observed with other enzymes. Hence, collagenase is
probably one of the key virulence markers of pathogenic AGNB, and the
inhibitors targeting collagenases might help in the therapy of
anaerobic infections.</description><identifier>ISSN: 0255-0857</identifier><identifier>DOI: 10.1016/S0255-0857(21)01996-4</identifier><identifier>PMID: 18227602</identifier><language>eng</language><publisher>India: Medknow Publications on behalf of Indian Association of Medical Microbiology</publisher><subject>Anaerobic gram-negative bacteria ; Anaerobic gram-negative bacteria, extra-cellular enzymes, virulence factors ; Bacterial Proteins - analysis ; Enzymes - analysis ; extra-cellular enzymes ; Gram-Negative Anaerobic Bacteria - enzymology ; Gram-Negative Anaerobic Bacteria - isolation & purification ; Gram-Negative Bacterial Infections - microbiology ; Humans ; virulence factors ; Virulence Factors - analysis</subject><ispartof>Indian journal of medical microbiology, 2008-01, Vol.26 (1), p.65-67</ispartof><rights>Copyright 2008 Indian Journal of Medical Microbiology.</rights><rights>2008 Indian Journal of Medical Microbiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-b2424-a636fcb27656ff3b77f2eed2999770bc620fcdc0ff009760c6cca2e99d59de863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925,64387,79426</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18227602$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nagmoti, JM</creatorcontrib><creatorcontrib>Patil, CS</creatorcontrib><creatorcontrib>Nagmoti, MB</creatorcontrib><creatorcontrib>Mutnal, MB</creatorcontrib><title>Detection of extra-cellular enzymes of anaerobic gram-negative bacteria from clinically diseased and healthy sites</title><title>Indian journal of medical microbiology</title><addtitle>Indian J Med Microbiol</addtitle><description>Anaerobic gram-negative bacteria (AGNB) produce enzymes that play a
significant role in the development of disease. We tested 50 AGNB
isolates, 25 each from clinically diseased and healthy human sites for
in vitro production of caseinase, collagenase, etc. Majority of the
isolates were Bacteroides fragilis and Porphyromonas gingivalis ,
which more commonly produced collagenase and haemolysin. Comparatively
larger number of clinical AGNB produced collagenase (P = 0.004). No
such difference was observed with other enzymes. Hence, collagenase is
probably one of the key virulence markers of pathogenic AGNB, and the
inhibitors targeting collagenases might help in the therapy of
anaerobic infections.</description><subject>Anaerobic gram-negative bacteria</subject><subject>Anaerobic gram-negative bacteria, extra-cellular enzymes, virulence factors</subject><subject>Bacterial Proteins - analysis</subject><subject>Enzymes - analysis</subject><subject>extra-cellular enzymes</subject><subject>Gram-Negative Anaerobic Bacteria - enzymology</subject><subject>Gram-Negative Anaerobic Bacteria - isolation & purification</subject><subject>Gram-Negative Bacterial Infections - microbiology</subject><subject>Humans</subject><subject>virulence factors</subject><subject>Virulence Factors - analysis</subject><issn>0255-0857</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>RBI</sourceid><sourceid>EIF</sourceid><recordid>eNqFkEtPJSEQhVmMGZ8_YQwro4tWoLvpy2oy0fGRmMxixjWBolBMd6PQ13j99cN9qEsTEkJxqk6dj5AfnJ1yxuXZXybatmKztjsW_IRxpWTVfCM7H-VtspvzIyvvRjXfyTafCdFJJnZIusAJYQpxpNFTfJ2SqQD7ft6bRHF8WwyYlz9mNJiiDUDvkxmqEe_NFF6QWgMTpmCoT3Gg0IcxgOn7BXUho8noSqejD2j66WFBc5gw75Mtb_qMB5t7j9xd_v53fl3d_rm6Of91W1nRiKYyspYebNmzld7Xtuu8QHRCKdV1zIIUzIMD5j1jqoQBCWAEKuVa5XAm6z1ytJ77lOLzHPOkh5CX2cyIcZ51x0RT1ythuxZCijkn9PophcGkheZMLwHrFWC9JKkF1yvAuil9hxuDuR3QfXZt6BbBz7UAS8yXgElnCDgCupAKdO1i-NLidD3BhljY4ocHFOb6vTjYctiM8ab-D7RAoAo</recordid><startdate>200801</startdate><enddate>200801</enddate><creator>Nagmoti, JM</creator><creator>Patil, CS</creator><creator>Nagmoti, MB</creator><creator>Mutnal, MB</creator><general>Medknow Publications on behalf of Indian Association of Medical Microbiology</general><general>Elsevier B.V</general><scope>RBI</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200801</creationdate><title>Detection of extra-cellular enzymes of anaerobic gram-negative bacteria from clinically diseased and healthy sites</title><author>Nagmoti, JM ; Patil, CS ; Nagmoti, MB ; Mutnal, MB</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b2424-a636fcb27656ff3b77f2eed2999770bc620fcdc0ff009760c6cca2e99d59de863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Anaerobic gram-negative bacteria</topic><topic>Anaerobic gram-negative bacteria, extra-cellular enzymes, virulence factors</topic><topic>Bacterial Proteins - analysis</topic><topic>Enzymes - analysis</topic><topic>extra-cellular enzymes</topic><topic>Gram-Negative Anaerobic Bacteria - enzymology</topic><topic>Gram-Negative Anaerobic Bacteria - isolation & purification</topic><topic>Gram-Negative Bacterial Infections - microbiology</topic><topic>Humans</topic><topic>virulence factors</topic><topic>Virulence Factors - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nagmoti, JM</creatorcontrib><creatorcontrib>Patil, CS</creatorcontrib><creatorcontrib>Nagmoti, MB</creatorcontrib><creatorcontrib>Mutnal, MB</creatorcontrib><collection>Bioline International</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Indian journal of medical microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nagmoti, JM</au><au>Patil, CS</au><au>Nagmoti, MB</au><au>Mutnal, MB</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detection of extra-cellular enzymes of anaerobic gram-negative bacteria from clinically diseased and healthy sites</atitle><jtitle>Indian journal of medical microbiology</jtitle><addtitle>Indian J Med Microbiol</addtitle><date>2008-01</date><risdate>2008</risdate><volume>26</volume><issue>1</issue><spage>65</spage><epage>67</epage><pages>65-67</pages><issn>0255-0857</issn><abstract>Anaerobic gram-negative bacteria (AGNB) produce enzymes that play a
significant role in the development of disease. We tested 50 AGNB
isolates, 25 each from clinically diseased and healthy human sites for
in vitro production of caseinase, collagenase, etc. Majority of the
isolates were Bacteroides fragilis and Porphyromonas gingivalis ,
which more commonly produced collagenase and haemolysin. Comparatively
larger number of clinical AGNB produced collagenase (P = 0.004). No
such difference was observed with other enzymes. Hence, collagenase is
probably one of the key virulence markers of pathogenic AGNB, and the
inhibitors targeting collagenases might help in the therapy of
anaerobic infections.</abstract><cop>India</cop><pub>Medknow Publications on behalf of Indian Association of Medical Microbiology</pub><pmid>18227602</pmid><doi>10.1016/S0255-0857(21)01996-4</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Indian journal of medical microbiology, 2008-01, Vol.26 (1), p.65-67 |
| issn | 0255-0857 |
| language | eng |
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| source | MEDLINE; Bioline International; EZB-FREE-00999 freely available EZB journals; ProQuest Central UK/Ireland; Alma/SFX Local Collection |
| subjects | Anaerobic gram-negative bacteria Anaerobic gram-negative bacteria, extra-cellular enzymes, virulence factors Bacterial Proteins - analysis Enzymes - analysis extra-cellular enzymes Gram-Negative Anaerobic Bacteria - enzymology Gram-Negative Anaerobic Bacteria - isolation & purification Gram-Negative Bacterial Infections - microbiology Humans virulence factors Virulence Factors - analysis |
| title | Detection of extra-cellular enzymes of anaerobic gram-negative bacteria from clinically diseased and healthy sites |
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