Inhibition of Experimental Periodontitis by a Topical Boron-based Antimicrobial
AN0128 is a boron-containing compound with antibacterial and anti-inflammatory properties. To test its potential effectiveness in treating periodontal disease, we induced experimental periodontitis in the rat by placing ligatures and assessed the impact of AN0128 and positive and negative controls b...
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| Veröffentlicht in: | Journal of dental research 2008-02, Vol.87 (2), p.148-152 |
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| creator | Luan, Q. Desta, T. Chehab, L. Sanders, V.J. Plattner, J. Graves, D.T. |
| description | AN0128 is a boron-containing compound with antibacterial and anti-inflammatory properties. To test its potential effectiveness in treating periodontal disease, we induced experimental periodontitis in the rat by placing ligatures and assessed the impact of AN0128 and positive and negative controls by micro-CT and histologic measurements. The formation of an inflammatory infiltrate was measured in hematoxylin-and-eosin-stained sections. Daily application of AN0128 (1%) compared with controls reduced bone loss by 38 to 44% (P < 0.05), while vehicle alone had no effect (P > 0.05). The reduction in bone loss with AN0128 was similar to that achieved with a NSAID, ketorolac, and Total toothpaste containing triclosan. AN0128 also reduced the level of gingival inflammation 42% compared with the ligature only (P < 0.05), whereas vehicle alone had no effect (P > 0.05). The results indicate that AN0128 significantly reduces the formation of an inflammatory infiltrate and reduces bone loss, measured histologically and by micro-CT. |
| doi_str_mv | 10.1177/154405910808700208 |
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To test its potential effectiveness in treating periodontal disease, we induced experimental periodontitis in the rat by placing ligatures and assessed the impact of AN0128 and positive and negative controls by micro-CT and histologic measurements. The formation of an inflammatory infiltrate was measured in hematoxylin-and-eosin-stained sections. Daily application of AN0128 (1%) compared with controls reduced bone loss by 38 to 44% (P < 0.05), while vehicle alone had no effect (P > 0.05). The reduction in bone loss with AN0128 was similar to that achieved with a NSAID, ketorolac, and Total toothpaste containing triclosan. AN0128 also reduced the level of gingival inflammation 42% compared with the ligature only (P < 0.05), whereas vehicle alone had no effect (P > 0.05). The results indicate that AN0128 significantly reduces the formation of an inflammatory infiltrate and reduces bone loss, measured histologically and by micro-CT.</description><identifier>ISSN: 0022-0345</identifier><identifier>EISSN: 1544-0591</identifier><identifier>DOI: 10.1177/154405910808700208</identifier><identifier>PMID: 18218841</identifier><identifier>CODEN: JDREAF</identifier><language>eng</language><publisher>United States: SAGE Publications</publisher><subject>Alveolar Bone Loss - pathology ; Alveolar Bone Loss - prevention & control ; Animals ; Anti-Bacterial Agents - therapeutic use ; Anti-Infective Agents, Local - therapeutic use ; Anti-Inflammatory Agents - therapeutic use ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Boranes - therapeutic use ; Coloring Agents ; Complex Mixtures - therapeutic use ; Dentifrices - therapeutic use ; Dentistry ; Ethylene Glycols ; Fluorescent Dyes ; Fluorides - therapeutic use ; Gingivitis - pathology ; Gingivitis - prevention & control ; Ketorolac - therapeutic use ; Male ; Periodontitis - pathology ; Periodontitis - prevention & control ; Pharmaceutical Vehicles ; Pyridines - therapeutic use ; Rats ; Rats, Sprague-Dawley ; Silicic Acid ; Tomography, X-Ray Computed - methods ; Toothpastes ; Triclosan - therapeutic use</subject><ispartof>Journal of dental research, 2008-02, Vol.87 (2), p.148-152</ispartof><rights>International and American Associations for Dental Research</rights><rights>Copyright American Association for Dental Research/American Academy of Implant Dentistry Feb 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c463t-afd9f189540154dd598dad3e6a58730c9450a2f763296b4fdeed97678ceac40a3</citedby><cites>FETCH-LOGICAL-c463t-afd9f189540154dd598dad3e6a58730c9450a2f763296b4fdeed97678ceac40a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/154405910808700208$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/154405910808700208$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18218841$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luan, Q.</creatorcontrib><creatorcontrib>Desta, T.</creatorcontrib><creatorcontrib>Chehab, L.</creatorcontrib><creatorcontrib>Sanders, V.J.</creatorcontrib><creatorcontrib>Plattner, J.</creatorcontrib><creatorcontrib>Graves, D.T.</creatorcontrib><title>Inhibition of Experimental Periodontitis by a Topical Boron-based Antimicrobial</title><title>Journal of dental research</title><addtitle>J Dent Res</addtitle><description>AN0128 is a boron-containing compound with antibacterial and anti-inflammatory properties. To test its potential effectiveness in treating periodontal disease, we induced experimental periodontitis in the rat by placing ligatures and assessed the impact of AN0128 and positive and negative controls by micro-CT and histologic measurements. The formation of an inflammatory infiltrate was measured in hematoxylin-and-eosin-stained sections. Daily application of AN0128 (1%) compared with controls reduced bone loss by 38 to 44% (P < 0.05), while vehicle alone had no effect (P > 0.05). The reduction in bone loss with AN0128 was similar to that achieved with a NSAID, ketorolac, and Total toothpaste containing triclosan. AN0128 also reduced the level of gingival inflammation 42% compared with the ligature only (P < 0.05), whereas vehicle alone had no effect (P > 0.05). The results indicate that AN0128 significantly reduces the formation of an inflammatory infiltrate and reduces bone loss, measured histologically and by micro-CT.</description><subject>Alveolar Bone Loss - pathology</subject><subject>Alveolar Bone Loss - prevention & control</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Anti-Infective Agents, Local - therapeutic use</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>Boranes - therapeutic use</subject><subject>Coloring Agents</subject><subject>Complex Mixtures - therapeutic use</subject><subject>Dentifrices - therapeutic use</subject><subject>Dentistry</subject><subject>Ethylene Glycols</subject><subject>Fluorescent Dyes</subject><subject>Fluorides - therapeutic use</subject><subject>Gingivitis - pathology</subject><subject>Gingivitis - prevention & control</subject><subject>Ketorolac - therapeutic use</subject><subject>Male</subject><subject>Periodontitis - pathology</subject><subject>Periodontitis - prevention & control</subject><subject>Pharmaceutical Vehicles</subject><subject>Pyridines - therapeutic use</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Silicic Acid</subject><subject>Tomography, X-Ray Computed - methods</subject><subject>Toothpastes</subject><subject>Triclosan - therapeutic use</subject><issn>0022-0345</issn><issn>1544-0591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kE9Lw0AQxRdRbK1-AQ8SPHiLnf2X7B5rqVoo1EM9h012o1uSbMwmYL-9W1ooKHja5c1v3sw8hG4xPGKcplPMGQMuMQgQKQABcYbGezHeq-doHDQSA2V8hK683wJgSQS9RCMsCBaC4TFaL5tPm9veuiZyZbT4bk1na9P0qorewtdp1_Sh7KN8F6lo41pbhNKT61wT58obHc0CUNuic7lV1TW6KFXlzc3xnaD358Vm_hqv1i_L-WwVFyyhfaxKLUssJGcQFtaaS6GVpiZRXKQUCsk4KFKmCSUyyVmpjdEyTVJRGFUwUHSCHg6-bee-BuP7rLa-MFWlGuMGn6VAGKU8CeD9L3Drhq4Ju2UEwhiCOQkQOUDhCu87U2ZtSEF1uwxDts86-5t1aLo7Og95bfSp5RhuAKYHwKsPcxr7j-UPZBCGEA</recordid><startdate>200802</startdate><enddate>200802</enddate><creator>Luan, Q.</creator><creator>Desta, T.</creator><creator>Chehab, L.</creator><creator>Sanders, V.J.</creator><creator>Plattner, J.</creator><creator>Graves, D.T.</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RQ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>200802</creationdate><title>Inhibition of Experimental Periodontitis by a Topical Boron-based Antimicrobial</title><author>Luan, Q. ; Desta, T. ; Chehab, L. ; Sanders, V.J. ; Plattner, J. ; Graves, D.T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-afd9f189540154dd598dad3e6a58730c9450a2f763296b4fdeed97678ceac40a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Alveolar Bone Loss - pathology</topic><topic>Alveolar Bone Loss - prevention & control</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Anti-Infective Agents, Local - therapeutic use</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</topic><topic>Boranes - therapeutic use</topic><topic>Coloring Agents</topic><topic>Complex Mixtures - therapeutic use</topic><topic>Dentifrices - therapeutic use</topic><topic>Dentistry</topic><topic>Ethylene Glycols</topic><topic>Fluorescent Dyes</topic><topic>Fluorides - therapeutic use</topic><topic>Gingivitis - pathology</topic><topic>Gingivitis - prevention & control</topic><topic>Ketorolac - therapeutic use</topic><topic>Male</topic><topic>Periodontitis - pathology</topic><topic>Periodontitis - prevention & control</topic><topic>Pharmaceutical Vehicles</topic><topic>Pyridines - therapeutic use</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Silicic Acid</topic><topic>Tomography, X-Ray Computed - methods</topic><topic>Toothpastes</topic><topic>Triclosan - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luan, Q.</creatorcontrib><creatorcontrib>Desta, T.</creatorcontrib><creatorcontrib>Chehab, L.</creatorcontrib><creatorcontrib>Sanders, V.J.</creatorcontrib><creatorcontrib>Plattner, J.</creatorcontrib><creatorcontrib>Graves, D.T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Career & Technical Education Database</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luan, Q.</au><au>Desta, T.</au><au>Chehab, L.</au><au>Sanders, V.J.</au><au>Plattner, J.</au><au>Graves, D.T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of Experimental Periodontitis by a Topical Boron-based Antimicrobial</atitle><jtitle>Journal of dental research</jtitle><addtitle>J Dent Res</addtitle><date>2008-02</date><risdate>2008</risdate><volume>87</volume><issue>2</issue><spage>148</spage><epage>152</epage><pages>148-152</pages><issn>0022-0345</issn><eissn>1544-0591</eissn><coden>JDREAF</coden><abstract>AN0128 is a boron-containing compound with antibacterial and anti-inflammatory properties. To test its potential effectiveness in treating periodontal disease, we induced experimental periodontitis in the rat by placing ligatures and assessed the impact of AN0128 and positive and negative controls by micro-CT and histologic measurements. The formation of an inflammatory infiltrate was measured in hematoxylin-and-eosin-stained sections. Daily application of AN0128 (1%) compared with controls reduced bone loss by 38 to 44% (P < 0.05), while vehicle alone had no effect (P > 0.05). The reduction in bone loss with AN0128 was similar to that achieved with a NSAID, ketorolac, and Total toothpaste containing triclosan. AN0128 also reduced the level of gingival inflammation 42% compared with the ligature only (P < 0.05), whereas vehicle alone had no effect (P > 0.05). The results indicate that AN0128 significantly reduces the formation of an inflammatory infiltrate and reduces bone loss, measured histologically and by micro-CT.</abstract><cop>United States</cop><pub>SAGE Publications</pub><pmid>18218841</pmid><doi>10.1177/154405910808700208</doi><tpages>5</tpages></addata></record> |
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| subjects | Alveolar Bone Loss - pathology Alveolar Bone Loss - prevention & control Animals Anti-Bacterial Agents - therapeutic use Anti-Infective Agents, Local - therapeutic use Anti-Inflammatory Agents - therapeutic use Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Boranes - therapeutic use Coloring Agents Complex Mixtures - therapeutic use Dentifrices - therapeutic use Dentistry Ethylene Glycols Fluorescent Dyes Fluorides - therapeutic use Gingivitis - pathology Gingivitis - prevention & control Ketorolac - therapeutic use Male Periodontitis - pathology Periodontitis - prevention & control Pharmaceutical Vehicles Pyridines - therapeutic use Rats Rats, Sprague-Dawley Silicic Acid Tomography, X-Ray Computed - methods Toothpastes Triclosan - therapeutic use |
| title | Inhibition of Experimental Periodontitis by a Topical Boron-based Antimicrobial |
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