Evaluation of probe drugs and pharmacokinetic metrics for CYP2D6 phenotyping

Cytochrome P450 2D6 (CYP2D6) is one of the most important enzymes catalyzing biotransformation of xenobiotics in the human liver. This enzyme's activity shows a high degree of interindividual variability caused in part by its genetic polymorphism, the so-called debrisoquine/sparteine polymorphi...

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Veröffentlicht in:	European journal of clinical pharmacology 2007-04, Vol.63 (4), p.321-333
Hauptverfasser:	FRANK, D, JAEHDE, U, FUHR, U
Format:	Artikel
Sprache:	eng
Schlagworte:	Area Under Curve Biochemistry Biological and medical sciences Cytochrome P-450 CYP2D6 - genetics Cytochrome P-450 CYP2D6 - metabolism Cytochrome P-450 CYP2D6 - physiology Debrisoquin - blood Debrisoquin - metabolism Debrisoquin - urine Dextromethorphan - blood Dextromethorphan - metabolism Dextromethorphan - urine Enzymes Evaluation Studies as Topic Genotype & phenotype Humans Medical sciences Pharmacology Pharmacology. Drug treatments Phenotype Polymorphism Polymorphism, Genetic
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