Shaping and reshaping CD8 + T-cell memory

Key Points Shortly after infection and/or vaccination, rare, antigen-specific CD8 + T cells encounter mature antigen-expressing dendritic cells (DCs), become activated and undergo extensive expansion in numbers following a 'programme' that is largely independent of the duration of the infe...

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Veröffentlicht in:	Nature reviews. Immunology 2008-02, Vol.8 (2), p.107-119
Hauptverfasser:	Harty, John T, Badovinac, Vladimir P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Biomedical and Life Sciences Biomedicine CD4-Positive T-Lymphocytes - immunology CD8 antigen CD8-Positive T-Lymphocytes - immunology Cell death Cytokines Dendritic cells Effector cells Epitopes Genotype & phenotype Humans Immune response Immunization Immunologic Memory Immunological memory Immunology Infections Infectious diseases Inflammation Inflammation - immunology Interleukin 12 Lymphocyte Activation Lymphocytes Lymphocytes T Memory cells Mice Pathogens Phenotypes review-article T cell receptors Transgenes Vaccination Vaccines γ-Interferon
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