Involvement of P2X4 and P2Y12 receptors in ATP-induced microglial chemotaxis

We previously reported that extracellular ATP induces membrane ruffling and chemotaxis of microglia and suggested that their induction is mediated by the Gi/o‐protein coupled P2Y12 receptor (P2Y12R). Here we report discovering that the P2X4 receptor (P2X4R) is also involved in ATP‐induced microglial...

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Veröffentlicht in:	Glia 2007-04, Vol.55 (6), p.604-616
Hauptverfasser:	Ohsawa, Keiko, Irino, Yasuhiro, Nakamura, Yasuko, Akazawa, Chihiro, Inoue, Kazuhide, Kohsaka, Shinichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Adenosine Triphosphate - pharmacology Animals Animals, Newborn ATP Cells, Cultured chemotaxis Chemotaxis - drug effects Chemotaxis - physiology Down-Regulation - physiology Enzyme Inhibitors - pharmacology Lentivirus Membrane Proteins - agonists Membrane Proteins - antagonists & inhibitors Membrane Proteins - metabolism microglia Microglia - drug effects Microglia - metabolism Oncogene Protein v-akt - drug effects Oncogene Protein v-akt - metabolism P2X4 P2Y12 Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - metabolism Phosphorylation - drug effects Purinergic P2 Receptor Agonists Purinergic P2 Receptor Antagonists Rats Rats, Wistar Receptors, Purinergic P2 - metabolism Receptors, Purinergic P2X4 Receptors, Purinergic P2Y12 RNA Interference - physiology Signal Transduction - drug effects Signal Transduction - physiology
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