Sarcoplasmic Ca2+ release is prolonged in nonfailing myocardium of diabetic patients

Background Asymptomatic diabetic patients have a high incidence of clinically unrecognized left ventricular dysfunction with an abnormal cardiac response to exercise. We, therefore, examined subclinical defects in the contraction–relaxation cycle and intracellular Ca 2+ regulation in myocardium of a...

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Veröffentlicht in:	Molecular and cellular biochemistry 2008-01, Vol.308 (1-2), p.141-149
Hauptverfasser:	Reuter, Hannes, Grönke, Sabine, Adam, Christian, Ribati, Maida, Brabender, Jan, Zobel, Carsten, Frank, Konrad F., Wippermann, Jens, Schwinger, Robert H. G., Brixius, Klara, Müller-Ehmsen, Jochen
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Calcium Calcium - metabolism Calcium Signaling Cardiology Cyclic AMP-Dependent Protein Kinases - metabolism Diabetes Diabetes Mellitus - metabolism Diabetes Mellitus - physiopathology Female Gene Expression Regulation, Enzymologic Heart Atria - enzymology Heart Atria - physiopathology Humans Isometric Contraction Kinases Life Sciences Male Medical Biochemistry Middle Aged Molecular biology Muscle Relaxation Myocardium - enzymology Myocardium - metabolism Myocardium - pathology Oncology Protein Kinase C - metabolism Proteins RNA, Messenger - genetics RNA, Messenger - metabolism Ryanodine Receptor Calcium Release Channel - metabolism Sarcoplasmic Reticulum - metabolism Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism
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