Investigation of a Flexible Enantiospecific Approach to Aziridines
A flexible approach to functionalized and enantioenriched aziridines has been developed from an intermediate aziridinylmethyl tosylate. This protocol features a Cu-catalyzed Grignard substitution reaction that allows a range of functionalized organic fragments to be incorporated. Moreover, a conveni...
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| Veröffentlicht in: | Journal of organic chemistry 2008-02, Vol.73 (3), p.1128-1130 |
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| container_end_page | 1130 |
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| container_issue | 3 |
| container_start_page | 1128 |
| container_title | Journal of organic chemistry |
| container_volume | 73 |
| creator | Jamookeeah, Clare E Beadle, Christopher D Jackson, Richard F. W Harrity, Joseph P. A |
| description | A flexible approach to functionalized and enantioenriched aziridines has been developed from an intermediate aziridinylmethyl tosylate. This protocol features a Cu-catalyzed Grignard substitution reaction that allows a range of functionalized organic fragments to be incorporated. Moreover, a convenient one-pot procedure is outlined that allows the trityl group to be exchanged for a range of common N-protecting groups. |
| doi_str_mv | 10.1021/jo7023637 |
| format | Article |
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| ispartof | Journal of organic chemistry, 2008-02, Vol.73 (3), p.1128-1130 |
| issn | 0022-3263 1520-6904 |
| language | eng |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Alkylation Aziridines - chemical synthesis Aziridines - chemistry Chemistry Copper - chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives Molecular Structure Organic chemistry Preparations and properties Stereoisomerism |
| title | Investigation of a Flexible Enantiospecific Approach to Aziridines |
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