Magnesium sulphate treatment decreases blood–brain barrier permeability during acute hypertension in pregnant rats

Eclampsia is associated with increased blood–brain barrier (BBB) permeability and formation of cerebral oedema. Magnesium sulphate is used to treat eclampsia despite an unclear mechanism of action. This study was to determine the effect of magnesium sulphate on in vivo BBB permeability and formation...

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Veröffentlicht in:	Experimental physiology 2008-02, Vol.93 (2), p.254-261
Hauptverfasser:	Euser, Anna G., Bullinger, Lisa, Cipolla, Marilyn J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aquaporin 4 - biosynthesis Blood-Brain Barrier - drug effects Blotting, Western Body Water - physiology Brain Edema - physiopathology Cerebrovascular Circulation - physiology Coloring Agents Evans Blue Female Glyceraldehyde-3-Phosphate Dehydrogenases - metabolism Hypertension, Pregnancy-Induced - metabolism Magnesium Sulfate - pharmacology Permeability Pregnancy Rats Rats, Sprague-Dawley
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