Plasma Uric Acid and the Risk of Type 2 Diabetes in a Chinese Community
Previous cross-sectional studies have shown hyperuricemia to be prevalent among individuals with metabolic syndrome, but the evidence from prospective studies of an association between uric acid and diabetes risk is limited. We prospectively investigated the association between plasma concentrations...
Gespeichert in:
| Veröffentlicht in: | Clinical chemistry (Baltimore, Md.) Md.), 2008-02, Vol.54 (2), p.310-316 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 316 |
|---|---|
| container_issue | 2 |
| container_start_page | 310 |
| container_title | Clinical chemistry (Baltimore, Md.) |
| container_volume | 54 |
| creator | Chien, Kuo-Liong Chen, Ming-Fong Hsu, Hsiu-Ching Chang, Wei-Tien Su, Ta-Chen Lee, Yuan-Teh Hu, Frank B |
| description | Previous cross-sectional studies have shown hyperuricemia to be prevalent among individuals with metabolic syndrome, but the evidence from prospective studies of an association between uric acid and diabetes risk is limited. We prospectively investigated the association between plasma concentrations of uric acid and the incidence of type 2 diabetes in Chinese individuals.
We conducted a community-based prospective cohort study of 2690 participants (age range, 35-97 years) in the Chin-Shan Community Cardiovascular Cohort Study, who were found to be free of diabetes and cardiovascular disease during baseline assessment at study entry in 1990. During a median 9.0-year follow-up, 548 participants developed type 2 diabetes.
High plasma uric acid concentrations were associated with a higher prevalence of metabolic syndrome. After adjustment for age, sex, body mass index, and other covariates, the relative risks (RR) of diabetes according to uric acid quintile were 1.11, 1.29, 1.40, and 1.63 [95% confidence interval (CI), 1.20-2.23; P for trend |
| doi_str_mv | 10.1373/clinchem.2007.095190 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70241324</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1433505191</sourcerecordid><originalsourceid>FETCH-LOGICAL-c504t-b10fb7756294819a55895879ae0693d8cc46e0cb5def7397b415a66fd9b7358b3</originalsourceid><addsrcrecordid>eNpdkW9rFDEQh4Mo9lr9BiJBsO_2Otkkm-RlOdsqFCzSvg7Z7Kybun_OZJfjvr057qzgvBkGnvkxPEPIBwZrxhW_8n0YfYfDugRQazCSGXhFVkxyKLSs2GuyAgBTGCbUGTlP6TmPQunqLTljGrSppFyRu4fepcHRpxg8vfahoW5s6Nwh_RHSLzq19HG_RVrSL8HVOGOiYaSObrowYkK6mYZhGcO8f0fetK5P-P7UL8jT7c3j5mtx__3u2-b6vvASxFzUDNpaKVmVRmhmnJTaSK2MQ6gMb7T3okLwtWywVdyoWjDpqqptTK241DW_IJfH3G2cfi-YZjuE5LHv3YjTkqyCUjBeigx--g98npY45ttsyURWoUvIkDhCPk4pRWztNobBxb1lYA-W7V_L9mDZHi3ntY-n7KUesPm3dNKagc8nwCXv-ja60Yf0wuUsyQ_1wnXhZ7cLEW3-Rd_nWGZ3u50UtrScAf8DoomQ7g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>214000820</pqid></control><display><type>article</type><title>Plasma Uric Acid and the Risk of Type 2 Diabetes in a Chinese Community</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><creator>Chien, Kuo-Liong ; Chen, Ming-Fong ; Hsu, Hsiu-Ching ; Chang, Wei-Tien ; Su, Ta-Chen ; Lee, Yuan-Teh ; Hu, Frank B</creator><creatorcontrib>Chien, Kuo-Liong ; Chen, Ming-Fong ; Hsu, Hsiu-Ching ; Chang, Wei-Tien ; Su, Ta-Chen ; Lee, Yuan-Teh ; Hu, Frank B</creatorcontrib><description>Previous cross-sectional studies have shown hyperuricemia to be prevalent among individuals with metabolic syndrome, but the evidence from prospective studies of an association between uric acid and diabetes risk is limited. We prospectively investigated the association between plasma concentrations of uric acid and the incidence of type 2 diabetes in Chinese individuals.
We conducted a community-based prospective cohort study of 2690 participants (age range, 35-97 years) in the Chin-Shan Community Cardiovascular Cohort Study, who were found to be free of diabetes and cardiovascular disease during baseline assessment at study entry in 1990. During a median 9.0-year follow-up, 548 participants developed type 2 diabetes.
High plasma uric acid concentrations were associated with a higher prevalence of metabolic syndrome. After adjustment for age, sex, body mass index, and other covariates, the relative risks (RR) of diabetes according to uric acid quintile were 1.11, 1.29, 1.40, and 1.63 [95% confidence interval (CI), 1.20-2.23; P for trend <0.001]. After additional adjustment for metabolic syndrome, the RR for comparing the participants in the fifth and first uric acid quintiles was 1.40 (95% CI, 1.02-1.92; P for trend = 0.027). In joint analyses, participants who were in the highest uric acid quintile and also had metabolic syndrome had a 3.3-fold greater risk of diabetes (95% CI, 2.27-4.94) than those in the lowest uric acid quintile and without metabolic syndrome.
These findings suggest a modest positive association between plasma uric acid concentration and the incidence of type 2 diabetes in Chinese individuals. The association between hyperuricemia and diabetes was partly mediated through the metabolic syndrome.</description><identifier>ISSN: 0009-9147</identifier><identifier>EISSN: 1530-8561</identifier><identifier>DOI: 10.1373/clinchem.2007.095190</identifier><identifier>PMID: 18089655</identifier><identifier>CODEN: CLCHAU</identifier><language>eng</language><publisher>Washington, DC: Am Assoc Clin Chem</publisher><subject>Acids ; Adult ; Aged ; Analytical, structural and metabolic biochemistry ; Asian Continental Ancestry Group ; Asian people ; Biological and medical sciences ; Biomarkers - blood ; Cardiovascular disease ; Cardiovascular diseases ; Diabetes ; Diabetes Mellitus, Type 2 - ethnology ; Diet ; Female ; Fundamental and applied biological sciences. Psychology ; Health risks ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Metabolic disorders ; Metabolic syndrome ; Middle Aged ; Multivariate Analysis ; Nutrition ; Physical examinations ; Plasma ; Prospective Studies ; Risk Factors ; Studies ; Taiwan - epidemiology ; Uric Acid - blood</subject><ispartof>Clinical chemistry (Baltimore, Md.), 2008-02, Vol.54 (2), p.310-316</ispartof><rights>2008 INIST-CNRS</rights><rights>Copyright American Association for Clinical Chemistry Feb 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-b10fb7756294819a55895879ae0693d8cc46e0cb5def7397b415a66fd9b7358b3</citedby><cites>FETCH-LOGICAL-c504t-b10fb7756294819a55895879ae0693d8cc46e0cb5def7397b415a66fd9b7358b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27913,27914</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20053333$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18089655$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chien, Kuo-Liong</creatorcontrib><creatorcontrib>Chen, Ming-Fong</creatorcontrib><creatorcontrib>Hsu, Hsiu-Ching</creatorcontrib><creatorcontrib>Chang, Wei-Tien</creatorcontrib><creatorcontrib>Su, Ta-Chen</creatorcontrib><creatorcontrib>Lee, Yuan-Teh</creatorcontrib><creatorcontrib>Hu, Frank B</creatorcontrib><title>Plasma Uric Acid and the Risk of Type 2 Diabetes in a Chinese Community</title><title>Clinical chemistry (Baltimore, Md.)</title><addtitle>Clin Chem</addtitle><description>Previous cross-sectional studies have shown hyperuricemia to be prevalent among individuals with metabolic syndrome, but the evidence from prospective studies of an association between uric acid and diabetes risk is limited. We prospectively investigated the association between plasma concentrations of uric acid and the incidence of type 2 diabetes in Chinese individuals.
We conducted a community-based prospective cohort study of 2690 participants (age range, 35-97 years) in the Chin-Shan Community Cardiovascular Cohort Study, who were found to be free of diabetes and cardiovascular disease during baseline assessment at study entry in 1990. During a median 9.0-year follow-up, 548 participants developed type 2 diabetes.
High plasma uric acid concentrations were associated with a higher prevalence of metabolic syndrome. After adjustment for age, sex, body mass index, and other covariates, the relative risks (RR) of diabetes according to uric acid quintile were 1.11, 1.29, 1.40, and 1.63 [95% confidence interval (CI), 1.20-2.23; P for trend <0.001]. After additional adjustment for metabolic syndrome, the RR for comparing the participants in the fifth and first uric acid quintiles was 1.40 (95% CI, 1.02-1.92; P for trend = 0.027). In joint analyses, participants who were in the highest uric acid quintile and also had metabolic syndrome had a 3.3-fold greater risk of diabetes (95% CI, 2.27-4.94) than those in the lowest uric acid quintile and without metabolic syndrome.
These findings suggest a modest positive association between plasma uric acid concentration and the incidence of type 2 diabetes in Chinese individuals. The association between hyperuricemia and diabetes was partly mediated through the metabolic syndrome.</description><subject>Acids</subject><subject>Adult</subject><subject>Aged</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Asian Continental Ancestry Group</subject><subject>Asian people</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - ethnology</subject><subject>Diet</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Health risks</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic disorders</subject><subject>Metabolic syndrome</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Nutrition</subject><subject>Physical examinations</subject><subject>Plasma</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Studies</subject><subject>Taiwan - epidemiology</subject><subject>Uric Acid - blood</subject><issn>0009-9147</issn><issn>1530-8561</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkW9rFDEQh4Mo9lr9BiJBsO_2Otkkm-RlOdsqFCzSvg7Z7Kybun_OZJfjvr057qzgvBkGnvkxPEPIBwZrxhW_8n0YfYfDugRQazCSGXhFVkxyKLSs2GuyAgBTGCbUGTlP6TmPQunqLTljGrSppFyRu4fepcHRpxg8vfahoW5s6Nwh_RHSLzq19HG_RVrSL8HVOGOiYaSObrowYkK6mYZhGcO8f0fetK5P-P7UL8jT7c3j5mtx__3u2-b6vvASxFzUDNpaKVmVRmhmnJTaSK2MQ6gMb7T3okLwtWywVdyoWjDpqqptTK241DW_IJfH3G2cfi-YZjuE5LHv3YjTkqyCUjBeigx--g98npY45ttsyURWoUvIkDhCPk4pRWztNobBxb1lYA-W7V_L9mDZHi3ntY-n7KUesPm3dNKagc8nwCXv-ja60Yf0wuUsyQ_1wnXhZ7cLEW3-Rd_nWGZ3u50UtrScAf8DoomQ7g</recordid><startdate>20080201</startdate><enddate>20080201</enddate><creator>Chien, Kuo-Liong</creator><creator>Chen, Ming-Fong</creator><creator>Hsu, Hsiu-Ching</creator><creator>Chang, Wei-Tien</creator><creator>Su, Ta-Chen</creator><creator>Lee, Yuan-Teh</creator><creator>Hu, Frank B</creator><general>Am Assoc Clin Chem</general><general>American Association for Clinical Chemistry</general><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4U-</scope><scope>7QO</scope><scope>7RV</scope><scope>7TM</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20080201</creationdate><title>Plasma Uric Acid and the Risk of Type 2 Diabetes in a Chinese Community</title><author>Chien, Kuo-Liong ; Chen, Ming-Fong ; Hsu, Hsiu-Ching ; Chang, Wei-Tien ; Su, Ta-Chen ; Lee, Yuan-Teh ; Hu, Frank B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-b10fb7756294819a55895879ae0693d8cc46e0cb5def7397b415a66fd9b7358b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Acids</topic><topic>Adult</topic><topic>Aged</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Asian Continental Ancestry Group</topic><topic>Asian people</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - ethnology</topic><topic>Diet</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Health risks</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic disorders</topic><topic>Metabolic syndrome</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Nutrition</topic><topic>Physical examinations</topic><topic>Plasma</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Studies</topic><topic>Taiwan - epidemiology</topic><topic>Uric Acid - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chien, Kuo-Liong</creatorcontrib><creatorcontrib>Chen, Ming-Fong</creatorcontrib><creatorcontrib>Hsu, Hsiu-Ching</creatorcontrib><creatorcontrib>Chang, Wei-Tien</creatorcontrib><creatorcontrib>Su, Ta-Chen</creatorcontrib><creatorcontrib>Lee, Yuan-Teh</creatorcontrib><creatorcontrib>Hu, Frank B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>University Readers</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical chemistry (Baltimore, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chien, Kuo-Liong</au><au>Chen, Ming-Fong</au><au>Hsu, Hsiu-Ching</au><au>Chang, Wei-Tien</au><au>Su, Ta-Chen</au><au>Lee, Yuan-Teh</au><au>Hu, Frank B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma Uric Acid and the Risk of Type 2 Diabetes in a Chinese Community</atitle><jtitle>Clinical chemistry (Baltimore, Md.)</jtitle><addtitle>Clin Chem</addtitle><date>2008-02-01</date><risdate>2008</risdate><volume>54</volume><issue>2</issue><spage>310</spage><epage>316</epage><pages>310-316</pages><issn>0009-9147</issn><eissn>1530-8561</eissn><coden>CLCHAU</coden><abstract>Previous cross-sectional studies have shown hyperuricemia to be prevalent among individuals with metabolic syndrome, but the evidence from prospective studies of an association between uric acid and diabetes risk is limited. We prospectively investigated the association between plasma concentrations of uric acid and the incidence of type 2 diabetes in Chinese individuals.
We conducted a community-based prospective cohort study of 2690 participants (age range, 35-97 years) in the Chin-Shan Community Cardiovascular Cohort Study, who were found to be free of diabetes and cardiovascular disease during baseline assessment at study entry in 1990. During a median 9.0-year follow-up, 548 participants developed type 2 diabetes.
High plasma uric acid concentrations were associated with a higher prevalence of metabolic syndrome. After adjustment for age, sex, body mass index, and other covariates, the relative risks (RR) of diabetes according to uric acid quintile were 1.11, 1.29, 1.40, and 1.63 [95% confidence interval (CI), 1.20-2.23; P for trend <0.001]. After additional adjustment for metabolic syndrome, the RR for comparing the participants in the fifth and first uric acid quintiles was 1.40 (95% CI, 1.02-1.92; P for trend = 0.027). In joint analyses, participants who were in the highest uric acid quintile and also had metabolic syndrome had a 3.3-fold greater risk of diabetes (95% CI, 2.27-4.94) than those in the lowest uric acid quintile and without metabolic syndrome.
These findings suggest a modest positive association between plasma uric acid concentration and the incidence of type 2 diabetes in Chinese individuals. The association between hyperuricemia and diabetes was partly mediated through the metabolic syndrome.</abstract><cop>Washington, DC</cop><pub>Am Assoc Clin Chem</pub><pmid>18089655</pmid><doi>10.1373/clinchem.2007.095190</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-9147 |
| ispartof | Clinical chemistry (Baltimore, Md.), 2008-02, Vol.54 (2), p.310-316 |
| issn | 0009-9147 1530-8561 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70241324 |
| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Acids Adult Aged Analytical, structural and metabolic biochemistry Asian Continental Ancestry Group Asian people Biological and medical sciences Biomarkers - blood Cardiovascular disease Cardiovascular diseases Diabetes Diabetes Mellitus, Type 2 - ethnology Diet Female Fundamental and applied biological sciences. Psychology Health risks Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Metabolic disorders Metabolic syndrome Middle Aged Multivariate Analysis Nutrition Physical examinations Plasma Prospective Studies Risk Factors Studies Taiwan - epidemiology Uric Acid - blood |
| title | Plasma Uric Acid and the Risk of Type 2 Diabetes in a Chinese Community |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T09%3A36%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Plasma%20Uric%20Acid%20and%20the%20Risk%20of%20Type%202%20Diabetes%20in%20a%20Chinese%20Community&rft.jtitle=Clinical%20chemistry%20(Baltimore,%20Md.)&rft.au=Chien,%20Kuo-Liong&rft.date=2008-02-01&rft.volume=54&rft.issue=2&rft.spage=310&rft.epage=316&rft.pages=310-316&rft.issn=0009-9147&rft.eissn=1530-8561&rft.coden=CLCHAU&rft_id=info:doi/10.1373/clinchem.2007.095190&rft_dat=%3Cproquest_cross%3E1433505191%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=214000820&rft_id=info:pmid/18089655&rfr_iscdi=true |