Isolation of Cytotoxic Metabolites from Targeted Peruvian Amazonian Medicinal Plants

The antiproliferative bioassay-guided fractionation of five Peruvian plants, Doliocarpus dentatus, Picramnia sellowii, Strychnos mitscherlichii, Iryanthera juruensis, and Croton alnifolius, led to the isolation and identification of their different major cytotoxic constituents, betulinic acid (1), n...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2008-01, Vol.71 (1), p.102-105
Hauptverfasser:	Aponte, José C, Vaisberg, Abraham J, Rojas, Rosario, Caviedes, Luz, Lewis, Walter H, Lamas, Gerardo, Sarasara, César, Gilman, Robert H, Hammond, Gerald B
Format:	Artikel
Sprache:	eng
Schlagworte:	antibacterial properties anticarcinogenic activity Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences cell proliferation Croton Croton alnifolius cultured cells cytotoxicity Doliocarpus Doliocarpus dentatus Drug Screening Assays, Antitumor forest trees General pharmacology Humans Iryanthera Iryanthera juruensis Medical sciences medicinal plants Microbial Sensitivity Tests Molecular Structure Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Peru Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Picramnia Picramnia sellowii Plants, Medicinal - chemistry rain forests Strychnos Strychnos - chemistry Strychnos mitscherlichii traditional medicine Triterpenes - chemistry Triterpenes - isolation & purification Triterpenes - pharmacology Tumor Cells, Cultured
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