Mechanisms of transcriptional regulation by MLL and its disruption in acute leukemia

Fusion of the mixed lineage leukemia protein (MLL) to one of over 50 different translocation partners converts it into a potent leukemogenic oncoprotein. The resulting fusion proteins transform primarily through upregulation of A-cluster Hox genes, including Hoxa9 and the Hox cofactor Meis1 . Consid...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of hematology 2008-01, Vol.87 (1), p.10-18
Hauptverfasser:	Dou, Yali, Hess, Jay L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Disease Models, Animal DNA Methylation Hematologic and hematopoietic diseases Hematology Histone-Lysine N-Methyltransferase Homeodomain Proteins - genetics Homeodomain Proteins - physiology Humans Leukemia - genetics Leukopoiesis - genetics Medical sciences Medicine Medicine & Public Health Mice Mice, Knockout Myeloid Ecotropic Viral Integration Site 1 Protein Myeloid-Lymphoid Leukemia Protein - genetics Myeloid-Lymphoid Leukemia Protein - physiology Neoplasm Proteins - genetics Neoplasm Proteins - physiology Oncology Progress in Hematology Transcription, Genetic - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!