Pneumococcal conjugate vaccine provides early protective antibody responses in children after related and unrelated allogeneic hematopoietic stem cell transplantation
Following allogeneic hematopoietic stem cell transplantation (alloHSCT), children are at risk of life-threatening pneumococcal infections. Whereas vaccination with polysaccharide vaccines fails to elicit protective immunity in most alloHSC transplant recipients, pneumococcal conjugate vaccines may e...
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| Veröffentlicht in: | Blood 2007-03, Vol.109 (6), p.2322-2326 |
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| creator | Meisel, Roland Kuypers, Lisa Dirksen, Uta Schubert, Ralf Gruhn, Bernd Strauss, Gabriele Beutel, Karin Groll, Andreas H. Duffner, Ulrich Blütters-Sawatzki, Renate Holter, Wolfgang Feuchtinger, Tobias Grüttner, Hans-Peter Schroten, Horst Zielen, Stefan Ohmann, Christian Laws, Hans-Jürgen Dilloo, Dagmar |
| description | Following allogeneic hematopoietic stem cell transplantation (alloHSCT), children are at risk of life-threatening pneumococcal infections. Whereas vaccination with polysaccharide vaccines fails to elicit protective immunity in most alloHSC transplant recipients, pneumococcal conjugate vaccines may effectively prevent invasive disease by eliciting T-cell–dependent antibody responses. Here, we report safety and immunogenicity in 53 children immunized with a regimen of 3 consecutive doses of a heptavalent pneumococcal conjugate vaccine (7vPCV) in monthly intervals starting 6 to 9 months after alloHSCT. Immunization was well tolerated with no vaccine-related serious adverse events. Serologic response rates evaluable in 43 patients ranged from 41.9% to 86.0% and 58.1% to 93.0% after 2 and 3 vaccinations, respectively, with 55.8% and 74.4% of patients achieving protective antibody levels to all 7 vaccine serotypes. Our study provides the first evidence that vaccination with 7vPCV is safe and elicits protective antipneumococcal antibody responses in pediatric recipients of related or unrelated donor alloHSC transplants within the first year following transplantation. This trial was registered at www.clinicaltrials.gov as NCT00169728. |
| doi_str_mv | 10.1182/blood-2006-06-032284 |
| format | Article |
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Whereas vaccination with polysaccharide vaccines fails to elicit protective immunity in most alloHSC transplant recipients, pneumococcal conjugate vaccines may effectively prevent invasive disease by eliciting T-cell–dependent antibody responses. Here, we report safety and immunogenicity in 53 children immunized with a regimen of 3 consecutive doses of a heptavalent pneumococcal conjugate vaccine (7vPCV) in monthly intervals starting 6 to 9 months after alloHSCT. Immunization was well tolerated with no vaccine-related serious adverse events. Serologic response rates evaluable in 43 patients ranged from 41.9% to 86.0% and 58.1% to 93.0% after 2 and 3 vaccinations, respectively, with 55.8% and 74.4% of patients achieving protective antibody levels to all 7 vaccine serotypes. Our study provides the first evidence that vaccination with 7vPCV is safe and elicits protective antipneumococcal antibody responses in pediatric recipients of related or unrelated donor alloHSC transplants within the first year following transplantation. This trial was registered at www.clinicaltrials.gov as NCT00169728.</description><identifier>ISSN: 0006-4971</identifier><identifier>EISSN: 1528-0020</identifier><identifier>DOI: 10.1182/blood-2006-06-032284</identifier><identifier>PMID: 17090650</identifier><language>eng</language><publisher>Washington, DC: Elsevier Inc</publisher><subject>Adolescent ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Antibody Formation - immunology ; Biological and medical sciences ; Bone marrow, stem cells transplantation. Graft versus host reaction ; Child ; Child, Preschool ; Female ; Hematopoietic Stem Cell Transplantation - adverse effects ; Humans ; Infant ; Male ; Medical sciences ; Pneumococcal Infections - immunology ; Pneumococcal Infections - prevention & control ; Pneumococcal Vaccines - administration & dosage ; Pneumococcal Vaccines - immunology ; Streptococcus pneumoniae - immunology ; Time Factors ; Transfusions. Complications. Transfusion reactions. 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Whereas vaccination with polysaccharide vaccines fails to elicit protective immunity in most alloHSC transplant recipients, pneumococcal conjugate vaccines may effectively prevent invasive disease by eliciting T-cell–dependent antibody responses. Here, we report safety and immunogenicity in 53 children immunized with a regimen of 3 consecutive doses of a heptavalent pneumococcal conjugate vaccine (7vPCV) in monthly intervals starting 6 to 9 months after alloHSCT. Immunization was well tolerated with no vaccine-related serious adverse events. Serologic response rates evaluable in 43 patients ranged from 41.9% to 86.0% and 58.1% to 93.0% after 2 and 3 vaccinations, respectively, with 55.8% and 74.4% of patients achieving protective antibody levels to all 7 vaccine serotypes. Our study provides the first evidence that vaccination with 7vPCV is safe and elicits protective antipneumococcal antibody responses in pediatric recipients of related or unrelated donor alloHSC transplants within the first year following transplantation. This trial was registered at www.clinicaltrials.gov as NCT00169728.</description><subject>Adolescent</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Antibody Formation - immunology</subject><subject>Biological and medical sciences</subject><subject>Bone marrow, stem cells transplantation. Graft versus host reaction</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Hematopoietic Stem Cell Transplantation - adverse effects</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pneumococcal Infections - immunology</subject><subject>Pneumococcal Infections - prevention & control</subject><subject>Pneumococcal Vaccines - administration & dosage</subject><subject>Pneumococcal Vaccines - immunology</subject><subject>Streptococcus pneumoniae - immunology</subject><subject>Time Factors</subject><subject>Transfusions. Complications. Transfusion reactions. 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Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Antibody Formation - immunology</topic><topic>Biological and medical sciences</topic><topic>Bone marrow, stem cells transplantation. Graft versus host reaction</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Hematopoietic Stem Cell Transplantation - adverse effects</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pneumococcal Infections - immunology</topic><topic>Pneumococcal Infections - prevention & control</topic><topic>Pneumococcal Vaccines - administration & dosage</topic><topic>Pneumococcal Vaccines - immunology</topic><topic>Streptococcus pneumoniae - immunology</topic><topic>Time Factors</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><topic>Transplantation, Homologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meisel, Roland</creatorcontrib><creatorcontrib>Kuypers, Lisa</creatorcontrib><creatorcontrib>Dirksen, Uta</creatorcontrib><creatorcontrib>Schubert, Ralf</creatorcontrib><creatorcontrib>Gruhn, Bernd</creatorcontrib><creatorcontrib>Strauss, Gabriele</creatorcontrib><creatorcontrib>Beutel, Karin</creatorcontrib><creatorcontrib>Groll, Andreas H.</creatorcontrib><creatorcontrib>Duffner, Ulrich</creatorcontrib><creatorcontrib>Blütters-Sawatzki, Renate</creatorcontrib><creatorcontrib>Holter, Wolfgang</creatorcontrib><creatorcontrib>Feuchtinger, Tobias</creatorcontrib><creatorcontrib>Grüttner, Hans-Peter</creatorcontrib><creatorcontrib>Schroten, Horst</creatorcontrib><creatorcontrib>Zielen, Stefan</creatorcontrib><creatorcontrib>Ohmann, Christian</creatorcontrib><creatorcontrib>Laws, Hans-Jürgen</creatorcontrib><creatorcontrib>Dilloo, Dagmar</creatorcontrib><creatorcontrib>for the Impfung von Kindern nach allogener Stammzelltransplantation (IKAST) Study Group</creatorcontrib><creatorcontrib>Impfung von Kindern nach allogener Stammzelltransplantation (IKAST) Study Group</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meisel, Roland</au><au>Kuypers, Lisa</au><au>Dirksen, Uta</au><au>Schubert, Ralf</au><au>Gruhn, Bernd</au><au>Strauss, Gabriele</au><au>Beutel, Karin</au><au>Groll, Andreas H.</au><au>Duffner, Ulrich</au><au>Blütters-Sawatzki, Renate</au><au>Holter, Wolfgang</au><au>Feuchtinger, Tobias</au><au>Grüttner, Hans-Peter</au><au>Schroten, Horst</au><au>Zielen, Stefan</au><au>Ohmann, Christian</au><au>Laws, Hans-Jürgen</au><au>Dilloo, Dagmar</au><aucorp>for the Impfung von Kindern nach allogener Stammzelltransplantation (IKAST) Study Group</aucorp><aucorp>Impfung von Kindern nach allogener Stammzelltransplantation (IKAST) Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pneumococcal conjugate vaccine provides early protective antibody responses in children after related and unrelated allogeneic hematopoietic stem cell transplantation</atitle><jtitle>Blood</jtitle><addtitle>Blood</addtitle><date>2007-03-15</date><risdate>2007</risdate><volume>109</volume><issue>6</issue><spage>2322</spage><epage>2326</epage><pages>2322-2326</pages><issn>0006-4971</issn><eissn>1528-0020</eissn><abstract>Following allogeneic hematopoietic stem cell transplantation (alloHSCT), children are at risk of life-threatening pneumococcal infections. Whereas vaccination with polysaccharide vaccines fails to elicit protective immunity in most alloHSC transplant recipients, pneumococcal conjugate vaccines may effectively prevent invasive disease by eliciting T-cell–dependent antibody responses. Here, we report safety and immunogenicity in 53 children immunized with a regimen of 3 consecutive doses of a heptavalent pneumococcal conjugate vaccine (7vPCV) in monthly intervals starting 6 to 9 months after alloHSCT. Immunization was well tolerated with no vaccine-related serious adverse events. Serologic response rates evaluable in 43 patients ranged from 41.9% to 86.0% and 58.1% to 93.0% after 2 and 3 vaccinations, respectively, with 55.8% and 74.4% of patients achieving protective antibody levels to all 7 vaccine serotypes. Our study provides the first evidence that vaccination with 7vPCV is safe and elicits protective antipneumococcal antibody responses in pediatric recipients of related or unrelated donor alloHSC transplants within the first year following transplantation. This trial was registered at www.clinicaltrials.gov as NCT00169728.</abstract><cop>Washington, DC</cop><pub>Elsevier Inc</pub><pmid>17090650</pmid><doi>10.1182/blood-2006-06-032284</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antibody Formation - immunology Biological and medical sciences Bone marrow, stem cells transplantation. Graft versus host reaction Child Child, Preschool Female Hematopoietic Stem Cell Transplantation - adverse effects Humans Infant Male Medical sciences Pneumococcal Infections - immunology Pneumococcal Infections - prevention & control Pneumococcal Vaccines - administration & dosage Pneumococcal Vaccines - immunology Streptococcus pneumoniae - immunology Time Factors Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation, Homologous |
| title | Pneumococcal conjugate vaccine provides early protective antibody responses in children after related and unrelated allogeneic hematopoietic stem cell transplantation |
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