Simultaneous determination of ten antiarrhythic drugs and a metabolite in human plasma by liquid chromatography—tandem mass spectrometry
A simple, accurate and selective LC–MS/MS method was developed and validated for simultaneous quantification of ten antiarrhythic drugs (diltiazem, amiodarone, mexiletine, propranolol, sotalol, verapamil, bisoprolol, metoprolol, atenolol, carvedilol) and a metabolite (norverapamil) in human plasma....
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| Veröffentlicht in: | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2007-03, Vol.847 (2), p.174-181 |
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| container_title | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences |
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| creator | Li, Shuijun Liu, Gangyi Jia, Jingying Liu, Yun Pan, Cheng Yu, Chen Cai, Yongbao Ren, Jianying |
| description | A simple, accurate and selective LC–MS/MS method was developed and validated for simultaneous quantification of ten antiarrhythic drugs (diltiazem, amiodarone, mexiletine, propranolol, sotalol, verapamil, bisoprolol, metoprolol, atenolol, carvedilol) and a metabolite (norverapamil) in human plasma. Plasma samples were simply pretreated with acetonitrile for deproteinization. Chromatographic separation was performed on a Capcell C
18 column (50
mm
×
2.0
mm, 5
μm) using a gradient mixture of acetonitrile and water (both containing 0.02% formic acid) as a mobile phase at flow rate of 0.3
ml/min. The analytes were protonated in the positive electrospray ionization (ESI) interface and detected in multiple reaction monitoring (MRM) mode. Calibration curves were linear over wide ranges from sub- to over-therapeutic concentration in plasma for all analytes. Intra- and inter-batch precision of analysis was |
| doi_str_mv | 10.1016/j.jchromb.2006.10.013 |
| format | Article |
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18 column (50
mm
×
2.0
mm, 5
μm) using a gradient mixture of acetonitrile and water (both containing 0.02% formic acid) as a mobile phase at flow rate of 0.3
ml/min. The analytes were protonated in the positive electrospray ionization (ESI) interface and detected in multiple reaction monitoring (MRM) mode. Calibration curves were linear over wide ranges from sub- to over-therapeutic concentration in plasma for all analytes. Intra- and inter-batch precision of analysis was <12.0%, accuracy ranged from 90% to 110%, average recovery from 85.0% to 99.7%. The validated method was successfully applied to therapeutic drug monitoring (TDM) of antiarrhythic drugs in routine clinical practice.</description><identifier>ISSN: 1570-0232</identifier><identifier>EISSN: 1873-376X</identifier><identifier>DOI: 10.1016/j.jchromb.2006.10.013</identifier><identifier>PMID: 17113839</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Amiodarone - blood ; Amiodarone - chemistry ; Analysis ; Analytical, structural and metabolic biochemistry ; Anti-Arrhythmia Agents - blood ; Anti-Arrhythmia Agents - chemistry ; Anti-Arrhythmia Agents - metabolism ; Antiarrhythic drugs ; Atenolol - blood ; Atenolol - chemistry ; Biological and medical sciences ; Bisoprolol - blood ; Bisoprolol - chemistry ; Carbazoles - blood ; Carbazoles - chemistry ; Chromatography, Liquid - methods ; Diltiazem - blood ; Diltiazem - chemistry ; Fundamental and applied biological sciences. Psychology ; General pharmacology ; Humans ; LC–MS/MS ; Medical sciences ; Metoprolol - blood ; Metoprolol - chemistry ; Mexiletine - blood ; Mexiletine - chemistry ; Molecular Structure ; Pharmacology. Drug treatments ; Propanolamines - blood ; Propanolamines - chemistry ; Propranolol - blood ; Propranolol - chemistry ; Reproducibility of Results ; Sotalol - blood ; Sotalol - chemistry ; Tandem Mass Spectrometry - methods ; Therapeutic drug monitoring ; Verapamil - analogs & derivatives ; Verapamil - blood ; Verapamil - chemistry ; Verapamil - metabolism</subject><ispartof>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007-03, Vol.847 (2), p.174-181</ispartof><rights>2006</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-44629b47d7cdb7d6a779c0a2115d4bd54aefa6caed2ab3180bffa410470e1c443</citedby><cites>FETCH-LOGICAL-c488t-44629b47d7cdb7d6a779c0a2115d4bd54aefa6caed2ab3180bffa410470e1c443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jchromb.2006.10.013$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18579019$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17113839$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Shuijun</creatorcontrib><creatorcontrib>Liu, Gangyi</creatorcontrib><creatorcontrib>Jia, Jingying</creatorcontrib><creatorcontrib>Liu, Yun</creatorcontrib><creatorcontrib>Pan, Cheng</creatorcontrib><creatorcontrib>Yu, Chen</creatorcontrib><creatorcontrib>Cai, Yongbao</creatorcontrib><creatorcontrib>Ren, Jianying</creatorcontrib><title>Simultaneous determination of ten antiarrhythic drugs and a metabolite in human plasma by liquid chromatography—tandem mass spectrometry</title><title>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences</title><addtitle>J Chromatogr B Analyt Technol Biomed Life Sci</addtitle><description>A simple, accurate and selective LC–MS/MS method was developed and validated for simultaneous quantification of ten antiarrhythic drugs (diltiazem, amiodarone, mexiletine, propranolol, sotalol, verapamil, bisoprolol, metoprolol, atenolol, carvedilol) and a metabolite (norverapamil) in human plasma. Plasma samples were simply pretreated with acetonitrile for deproteinization. Chromatographic separation was performed on a Capcell C
18 column (50
mm
×
2.0
mm, 5
μm) using a gradient mixture of acetonitrile and water (both containing 0.02% formic acid) as a mobile phase at flow rate of 0.3
ml/min. The analytes were protonated in the positive electrospray ionization (ESI) interface and detected in multiple reaction monitoring (MRM) mode. Calibration curves were linear over wide ranges from sub- to over-therapeutic concentration in plasma for all analytes. Intra- and inter-batch precision of analysis was <12.0%, accuracy ranged from 90% to 110%, average recovery from 85.0% to 99.7%. The validated method was successfully applied to therapeutic drug monitoring (TDM) of antiarrhythic drugs in routine clinical practice.</description><subject>Amiodarone - blood</subject><subject>Amiodarone - chemistry</subject><subject>Analysis</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Anti-Arrhythmia Agents - blood</subject><subject>Anti-Arrhythmia Agents - chemistry</subject><subject>Anti-Arrhythmia Agents - metabolism</subject><subject>Antiarrhythic drugs</subject><subject>Atenolol - blood</subject><subject>Atenolol - chemistry</subject><subject>Biological and medical sciences</subject><subject>Bisoprolol - blood</subject><subject>Bisoprolol - chemistry</subject><subject>Carbazoles - blood</subject><subject>Carbazoles - chemistry</subject><subject>Chromatography, Liquid - methods</subject><subject>Diltiazem - blood</subject><subject>Diltiazem - chemistry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>LC–MS/MS</subject><subject>Medical sciences</subject><subject>Metoprolol - blood</subject><subject>Metoprolol - chemistry</subject><subject>Mexiletine - blood</subject><subject>Mexiletine - chemistry</subject><subject>Molecular Structure</subject><subject>Pharmacology. Drug treatments</subject><subject>Propanolamines - blood</subject><subject>Propanolamines - chemistry</subject><subject>Propranolol - blood</subject><subject>Propranolol - chemistry</subject><subject>Reproducibility of Results</subject><subject>Sotalol - blood</subject><subject>Sotalol - chemistry</subject><subject>Tandem Mass Spectrometry - methods</subject><subject>Therapeutic drug monitoring</subject><subject>Verapamil - analogs & derivatives</subject><subject>Verapamil - blood</subject><subject>Verapamil - chemistry</subject><subject>Verapamil - metabolism</subject><issn>1570-0232</issn><issn>1873-376X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQhyNERUvhEUC-wC1bO3bi7Amhin9SpR4AiZs1tieNV3GS2g5Sbpw584R9ErxspB452Rp_4xl9v6J4xeiOUdZcHXYH04fJ611FaZNrO8r4k-KCtZKXXDY_nuZ7LWlJK16dF89jPFDKJJX8WXHOJGO85fuL4vdX55chwYjTEonFhMG7EZKbRjJ1JOFIYEwOQujX1DtDbFjuYq5ZAsRjAj0NLiFxI-kXDyOZB4geiF7J4O4XZ8m_LSFNdwHmfn349ScPs-iJhxhJnNGk_I4prC-Ksw6GiC-387L4_vHDt-vP5c3tpy_X729KI9o2lUI01V4LaaWxWtoGpNwbChVjtRXa1gKwg8YA2go0Zy3VXQeCUSEpMiMEvyzenv6dw3S_YEzKu2hwGE4SlMzGspsqg_UJNGGKMWCn5uA8hFUxqo4hqIPaQlDHEI7lHELue70NWLRH-9i1Wc_Amw2AaGDoAozGxUeureWesiP37sRh1vHTYVDROBwNWheyN2Un959V_gLPzq2u</recordid><startdate>20070301</startdate><enddate>20070301</enddate><creator>Li, Shuijun</creator><creator>Liu, Gangyi</creator><creator>Jia, Jingying</creator><creator>Liu, Yun</creator><creator>Pan, Cheng</creator><creator>Yu, Chen</creator><creator>Cai, Yongbao</creator><creator>Ren, Jianying</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070301</creationdate><title>Simultaneous determination of ten antiarrhythic drugs and a metabolite in human plasma by liquid chromatography—tandem mass spectrometry</title><author>Li, Shuijun ; Liu, Gangyi ; Jia, Jingying ; Liu, Yun ; Pan, Cheng ; Yu, Chen ; Cai, Yongbao ; Ren, Jianying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-44629b47d7cdb7d6a779c0a2115d4bd54aefa6caed2ab3180bffa410470e1c443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Amiodarone - blood</topic><topic>Amiodarone - chemistry</topic><topic>Analysis</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Anti-Arrhythmia Agents - blood</topic><topic>Anti-Arrhythmia Agents - chemistry</topic><topic>Anti-Arrhythmia Agents - metabolism</topic><topic>Antiarrhythic drugs</topic><topic>Atenolol - blood</topic><topic>Atenolol - chemistry</topic><topic>Biological and medical sciences</topic><topic>Bisoprolol - blood</topic><topic>Bisoprolol - chemistry</topic><topic>Carbazoles - blood</topic><topic>Carbazoles - chemistry</topic><topic>Chromatography, Liquid - methods</topic><topic>Diltiazem - blood</topic><topic>Diltiazem - chemistry</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>LC–MS/MS</topic><topic>Medical sciences</topic><topic>Metoprolol - blood</topic><topic>Metoprolol - chemistry</topic><topic>Mexiletine - blood</topic><topic>Mexiletine - chemistry</topic><topic>Molecular Structure</topic><topic>Pharmacology. Drug treatments</topic><topic>Propanolamines - blood</topic><topic>Propanolamines - chemistry</topic><topic>Propranolol - blood</topic><topic>Propranolol - chemistry</topic><topic>Reproducibility of Results</topic><topic>Sotalol - blood</topic><topic>Sotalol - chemistry</topic><topic>Tandem Mass Spectrometry - methods</topic><topic>Therapeutic drug monitoring</topic><topic>Verapamil - analogs & derivatives</topic><topic>Verapamil - blood</topic><topic>Verapamil - chemistry</topic><topic>Verapamil - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Shuijun</creatorcontrib><creatorcontrib>Liu, Gangyi</creatorcontrib><creatorcontrib>Jia, Jingying</creatorcontrib><creatorcontrib>Liu, Yun</creatorcontrib><creatorcontrib>Pan, Cheng</creatorcontrib><creatorcontrib>Yu, Chen</creatorcontrib><creatorcontrib>Cai, Yongbao</creatorcontrib><creatorcontrib>Ren, Jianying</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Shuijun</au><au>Liu, Gangyi</au><au>Jia, Jingying</au><au>Liu, Yun</au><au>Pan, Cheng</au><au>Yu, Chen</au><au>Cai, Yongbao</au><au>Ren, Jianying</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Simultaneous determination of ten antiarrhythic drugs and a metabolite in human plasma by liquid chromatography—tandem mass spectrometry</atitle><jtitle>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences</jtitle><addtitle>J Chromatogr B Analyt Technol Biomed Life Sci</addtitle><date>2007-03-01</date><risdate>2007</risdate><volume>847</volume><issue>2</issue><spage>174</spage><epage>181</epage><pages>174-181</pages><issn>1570-0232</issn><eissn>1873-376X</eissn><abstract>A simple, accurate and selective LC–MS/MS method was developed and validated for simultaneous quantification of ten antiarrhythic drugs (diltiazem, amiodarone, mexiletine, propranolol, sotalol, verapamil, bisoprolol, metoprolol, atenolol, carvedilol) and a metabolite (norverapamil) in human plasma. Plasma samples were simply pretreated with acetonitrile for deproteinization. Chromatographic separation was performed on a Capcell C
18 column (50
mm
×
2.0
mm, 5
μm) using a gradient mixture of acetonitrile and water (both containing 0.02% formic acid) as a mobile phase at flow rate of 0.3
ml/min. The analytes were protonated in the positive electrospray ionization (ESI) interface and detected in multiple reaction monitoring (MRM) mode. Calibration curves were linear over wide ranges from sub- to over-therapeutic concentration in plasma for all analytes. Intra- and inter-batch precision of analysis was <12.0%, accuracy ranged from 90% to 110%, average recovery from 85.0% to 99.7%. The validated method was successfully applied to therapeutic drug monitoring (TDM) of antiarrhythic drugs in routine clinical practice.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>17113839</pmid><doi>10.1016/j.jchromb.2006.10.013</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1570-0232 |
| ispartof | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007-03, Vol.847 (2), p.174-181 |
| issn | 1570-0232 1873-376X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70238392 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Amiodarone - blood Amiodarone - chemistry Analysis Analytical, structural and metabolic biochemistry Anti-Arrhythmia Agents - blood Anti-Arrhythmia Agents - chemistry Anti-Arrhythmia Agents - metabolism Antiarrhythic drugs Atenolol - blood Atenolol - chemistry Biological and medical sciences Bisoprolol - blood Bisoprolol - chemistry Carbazoles - blood Carbazoles - chemistry Chromatography, Liquid - methods Diltiazem - blood Diltiazem - chemistry Fundamental and applied biological sciences. Psychology General pharmacology Humans LC–MS/MS Medical sciences Metoprolol - blood Metoprolol - chemistry Mexiletine - blood Mexiletine - chemistry Molecular Structure Pharmacology. Drug treatments Propanolamines - blood Propanolamines - chemistry Propranolol - blood Propranolol - chemistry Reproducibility of Results Sotalol - blood Sotalol - chemistry Tandem Mass Spectrometry - methods Therapeutic drug monitoring Verapamil - analogs & derivatives Verapamil - blood Verapamil - chemistry Verapamil - metabolism |
| title | Simultaneous determination of ten antiarrhythic drugs and a metabolite in human plasma by liquid chromatography—tandem mass spectrometry |
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