Tolerance and Chimerism after Renal and Hematopoietic-Cell Transplantation

A patient received a kidney graft from his HLA-identical brother, followed by an infusion of CD34+ hematopoietic stem cells from the same donor. An apparent state of immunologic tolerance to the kidney allograft developed, allowing withdrawal of all immunosuppressive therapy within 6 months. A patie...

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Veröffentlicht in:	The New England journal of medicine 2008-01, Vol.358 (4), p.362-368
Hauptverfasser:	Scandling, John D, Busque, Stephan, Dejbakhsh-Jones, Sussan, Benike, Claudia, Millan, Maria T, Shizuru, Judith A, Hoppe, Richard T, Lowsky, Robert, Engleman, Edgar G, Strober, Samuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Combined Modality Therapy General aspects Hematopoietic Stem Cell Transplantation Histocompatibility Testing Humans Kidney Failure, Chronic - surgery Kidney Transplantation - immunology Lymphocyte Count Male Medical sciences Middle Aged Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the urinary system T-Lymphocytes - immunology Transplantation Chimera - immunology Transplantation Conditioning Transplantation Immunology Transplantation Tolerance - immunology Transplantation, Homologous
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