Activation of transcription factor c- jun in dorsal root ganglia induces VIP and NPY upregulation and contributes to the pathogenesis of neuropathic pain

Vasoactive intestinal peptide (VIP) and neuropeptide Y (NPY) in dorsal root ganglia (DRGs) are known to be upregulated and to contribute to the mechanisms of neuropathic pain following peripheral nerve injury. Moreover, transcription factor c-Jun regulates the expressions of both VIP and NPY in cult...

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Veröffentlicht in:	Experimental neurology 2007-03, Vol.204 (1), p.467-472
Hauptverfasser:	Son, Sun-Joo, Lee, Kyung-Min, Jeon, Sang-Min, Park, Eun-Sung, Park, Kwon-Moo, Cho, Hee-Jung
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Constriction, Pathologic Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction Ganglia, Spinal - cytology Ganglia, Spinal - metabolism Hot Temperature Hypesthesia - physiopathology Immunohistochemistry Injuries of the nervous system and the skull. Diseases due to physical agents Male Medical sciences Nervous system (semeiology, syndromes) Neuralgia - etiology Neurology Neurons - metabolism Neuropeptide Y - genetics Neuropeptide Y - metabolism Oligonucleotides, Antisense - pharmacology Phosphorylation - drug effects Physical Stimulation Proto-Oncogene Proteins c-jun - genetics Proto-Oncogene Proteins c-jun - metabolism Rats Rats, Sprague-Dawley RNA, Messenger - antagonists & inhibitors RNA, Messenger - metabolism Sciatic Nerve - injuries Time Factors Traumas. Diseases due to physical agents Up-Regulation Vasoactive Intestinal Peptide - genetics Vasoactive Intestinal Peptide - metabolism
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