Low-density lipoprotein receptor-related protein 5 (LRP5) mediates the prostate cancer-induced formation of new bone

The tendency of prostate cancer to produce osteoblastic bone metastases suggests that cancer cells and osteoblasts interact in ways that contribute to cancer progression. To identify factors that mediate these interactions, we compared gene expression patterns between two bone-derived prostate cance...

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Veröffentlicht in:	Oncogene 2008-01, Vol.27 (5), p.596-603
Hauptverfasser:	Li, Z G, Yang, J, Vazquez, E S, Rose, D, Vakar-Lopez, F, Mathew, P, Lopez, A, Logothetis, C J, Lin, S-H, Navone, N M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis B cells Biological and medical sciences Bone cancer Bone growth Bone Neoplasms - metabolism Bone Neoplasms - secondary Bone resorption Bone tumors Bones Calvaria Cancer metastasis Cell Biology Cell growth Cell Line, Tumor Cell physiology Cell proliferation Cell receptors Cell structures and functions Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cellular biology Development and progression Dkk1 protein Fundamental and applied biological sciences. Psychology Gene expression Human Genetics Humans Intercellular Signaling Peptides and Proteins - metabolism Internal Medicine LDL-Receptor Related Proteins - metabolism Low Density Lipoprotein Receptor-Related Protein-5 Low density lipoproteins LRP5 protein Male Medical sciences Medicine Medicine & Public Health Metastases Metastasis Mice Miscellaneous Molecular and cellular biology Nephrology. Urinary tract diseases Oncology original-article Osteoblasts Osteoblasts - metabolism Osteogenesis Osteolysis Phenotype Phenotypes Prostate cancer Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Receptor density Signal Transduction Tumor cell lines Tumors of the urinary system Urinary tract. Prostate gland Wnt protein Wnt Proteins - metabolism
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