Reversal of inflammation‐associated dihydrodiol dehydrogenases (AKR1C1 and AKR1C2) overexpression and drug resistance in nonsmall cell lung cancer cells by wogonin and chrysin

Dihydrodiol dehydrogenase (DDH) is a member of the aldo‐keto reductases superfamily (AKR1C1–AKR1C4), which plays central roles in the metabolism of steroid hormone, prostaglandin and xenobiotics. We have previously detected overexpression of DDH as an indicator of poor prognosis and chemoresistance...

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Veröffentlicht in:	International journal of cancer 2007-05, Vol.120 (9), p.2019-2027
Hauptverfasser:	Wang, Hao‐Wei, Lin, Chin‐Ping, Chiu, Jen‐Hwey, Chow, Kuan‐Chih, Kuo, Kuang‐Tai, Lin, Chen‐Sung, Wang, Liang‐Shun
Format:	Artikel
Sprache:	eng
Schlagworte:	20-Hydroxysteroid Dehydrogenases - antagonists & inhibitors 20-Hydroxysteroid Dehydrogenases - physiology aldo‐keto reductase (AKR) Antineoplastic agents Apoptosis Biological and medical sciences carcinoma Carcinoma, Non-Small-Cell Lung - drug therapy Cell Cycle Cell Line, Tumor cytokines dihydrodiol dehydrogenase DNA Repair Dose-Response Relationship, Drug Doxorubicin - pharmacology drug resistance Drug Resistance, Neoplasm Flavanones - pharmacology Flavonoids - pharmacology General aspects Humans Hydroxysteroid Dehydrogenases - antagonists & inhibitors Hydroxysteroid Dehydrogenases - physiology Interleukin-6 - pharmacology Lung Neoplasms - drug therapy Medical sciences non‐small‐cell lung Pharmacology. Drug treatments Tumors
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