Long-Term Effects of Central Leptin and Resistin on Body Weight, Insulin Resistance, and β-Cell Function and Mass by the Modulation of Hypothalamic Leptin and Insulin Signaling

To determine the long-term effect of central leptin and resistin on energy homeostasis, peripheral insulin resistance, and β-cell function and mass, intracerebroventricular (ICV) infusion of leptin (3 ng/h), resistin (80 ng/h), leptin plus resistin, and cerebrospinal fluid (control) was conducted by...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Endocrinology (Philadelphia) 2008-02, Vol.149 (2), p.445-454
Hauptverfasser:	Park, Sunmin, Hong, Sang Mee, Sung, So Ra, Jung, Hye Kyung
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Animals Apoptosis - physiology Beta cells Biological and medical sciences Blood Glucose - metabolism Body weight Body Weight - drug effects Cell Division - physiology Cell proliferation Cerebrospinal fluid Diabetes Diabetes mellitus Eating - drug effects Eating - physiology Energy balance Food intake Fundamental and applied biological sciences. Psychology Glucose Glucose Clamp Technique Glucose Tolerance Test Homeostasis Hyperinsulinism - metabolism Hypothalamus Hypothalamus - metabolism Injections, Intraventricular Insulin Insulin - blood Insulin - metabolism Insulin resistance Insulin Resistance - physiology Insulin Secretion Insulin-Like Growth Factor I - metabolism Insulin-Secreting Cells - cytology Insulin-Secreting Cells - metabolism Insulin-Secreting Cells - physiology Kinases Leptin Leptin - blood Leptin - pharmacology Long-term effects Male Pancreatectomy Phosphorylation Rats Rats, Sprague-Dawley Resistin - blood Resistin - pharmacology Signal Transduction - physiology Vertebrates: endocrinology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!