Expression of androgen receptor and its co-localization with estrogen receptor-alpha in the developing pituitary gland of sheep fetus
No information is known concerning the expression of androgen receptor (AR) and its co-localization with estrogen receptor alpha (ERalpha) in the developing pituitary of sheep fetus. In the present study, we detected AR expression and its co-localization with ERalpha in the anterior pituitary of she...
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| Veröffentlicht in: | Histochemistry and cell biology 2007-04, Vol.127 (4), p.423-432 |
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| creator | Yuan, XueJun He, YuQin Liu, JiaLi Luo, HaoShu Zhang, JinHua Cui, Sheng |
| description | No information is known concerning the expression of androgen receptor (AR) and its co-localization with estrogen receptor alpha (ERalpha) in the developing pituitary of sheep fetus. In the present study, we detected AR expression and its co-localization with ERalpha in the anterior pituitary of sheep fetus from day 60 of gestation to the postnatal by dual immunochemistry. The results showed that both AR immunoreactivity (AR-ir) and ERalpha immunoreactivity (ERalpha-ir) were predominantly localized in the nuclei of LH positive gonadotropes. The cell counting results showed that the percentage of the anterior pituitary cells expressing AR fluctuated from 13.51 +/- 0.92 to 17.05 +/- 1.83% during the examined stages, but there were no significant differences between sexes and among ages examined (P > 0.05). However, the proportion of AR-ir cells containing LH markedly increased from day 60 of gestation to the neonatal (P < 0.05). The percentage of AR-ir cells expressing ERalpha-ir significantly increased from day 60 of gestation to the neonatal, respectively (P < 0.05), but no significant differences were seen between genders at each stage examined. These results indicate that both AR and ERalpha are mainly expressed in the gonadotropes of anterior pituitary gland of sheep fetuses, whereas the functions and interaction of AR and ERalpha expressions in the developing pituitary gland are required to be elucidated further. |
| doi_str_mv | 10.1007/s00418-006-0262-6 |
| format | Article |
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In the present study, we detected AR expression and its co-localization with ERalpha in the anterior pituitary of sheep fetus from day 60 of gestation to the postnatal by dual immunochemistry. The results showed that both AR immunoreactivity (AR-ir) and ERalpha immunoreactivity (ERalpha-ir) were predominantly localized in the nuclei of LH positive gonadotropes. The cell counting results showed that the percentage of the anterior pituitary cells expressing AR fluctuated from 13.51 +/- 0.92 to 17.05 +/- 1.83% during the examined stages, but there were no significant differences between sexes and among ages examined (P > 0.05). However, the proportion of AR-ir cells containing LH markedly increased from day 60 of gestation to the neonatal (P < 0.05). The percentage of AR-ir cells expressing ERalpha-ir significantly increased from day 60 of gestation to the neonatal, respectively (P < 0.05), but no significant differences were seen between genders at each stage examined. These results indicate that both AR and ERalpha are mainly expressed in the gonadotropes of anterior pituitary gland of sheep fetuses, whereas the functions and interaction of AR and ERalpha expressions in the developing pituitary gland are required to be elucidated further.</description><identifier>ISSN: 0948-6143</identifier><identifier>EISSN: 1432-119X</identifier><identifier>DOI: 10.1007/s00418-006-0262-6</identifier><identifier>PMID: 17205307</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Anatomy & physiology ; Animals ; Animals, Newborn ; Cellular biology ; Estrogen Receptor alpha - analysis ; Estrogens ; Female ; Fetus - chemistry ; Fetuses ; Gene expression ; Immunohistochemistry ; Male ; Pituitary gland ; Pituitary Gland - chemistry ; Pituitary Gland - cytology ; Pituitary Gland - embryology ; Pregnancy ; Prenatal development ; Proliferating Cell Nuclear Antigen - analysis ; Receptors, Androgen - analysis ; Receptors, Androgen - biosynthesis ; Sheep ; Testosterone - blood</subject><ispartof>Histochemistry and cell biology, 2007-04, Vol.127 (4), p.423-432</ispartof><rights>Springer-Verlag 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c326t-56454baa04595e2f11e92cf30dad4a801dad5bdc32151ec403c4ed4f1ec2b98d3</citedby><cites>FETCH-LOGICAL-c326t-56454baa04595e2f11e92cf30dad4a801dad5bdc32151ec403c4ed4f1ec2b98d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17205307$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yuan, XueJun</creatorcontrib><creatorcontrib>He, YuQin</creatorcontrib><creatorcontrib>Liu, JiaLi</creatorcontrib><creatorcontrib>Luo, HaoShu</creatorcontrib><creatorcontrib>Zhang, JinHua</creatorcontrib><creatorcontrib>Cui, Sheng</creatorcontrib><title>Expression of androgen receptor and its co-localization with estrogen receptor-alpha in the developing pituitary gland of sheep fetus</title><title>Histochemistry and cell biology</title><addtitle>Histochem Cell Biol</addtitle><description>No information is known concerning the expression of androgen receptor (AR) and its co-localization with estrogen receptor alpha (ERalpha) in the developing pituitary of sheep fetus. In the present study, we detected AR expression and its co-localization with ERalpha in the anterior pituitary of sheep fetus from day 60 of gestation to the postnatal by dual immunochemistry. The results showed that both AR immunoreactivity (AR-ir) and ERalpha immunoreactivity (ERalpha-ir) were predominantly localized in the nuclei of LH positive gonadotropes. The cell counting results showed that the percentage of the anterior pituitary cells expressing AR fluctuated from 13.51 +/- 0.92 to 17.05 +/- 1.83% during the examined stages, but there were no significant differences between sexes and among ages examined (P > 0.05). However, the proportion of AR-ir cells containing LH markedly increased from day 60 of gestation to the neonatal (P < 0.05). The percentage of AR-ir cells expressing ERalpha-ir significantly increased from day 60 of gestation to the neonatal, respectively (P < 0.05), but no significant differences were seen between genders at each stage examined. 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He, YuQin ; Liu, JiaLi ; Luo, HaoShu ; Zhang, JinHua ; Cui, Sheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-56454baa04595e2f11e92cf30dad4a801dad5bdc32151ec403c4ed4f1ec2b98d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Anatomy & physiology</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Cellular biology</topic><topic>Estrogen Receptor alpha - analysis</topic><topic>Estrogens</topic><topic>Female</topic><topic>Fetus - chemistry</topic><topic>Fetuses</topic><topic>Gene expression</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Pituitary gland</topic><topic>Pituitary Gland - chemistry</topic><topic>Pituitary Gland - cytology</topic><topic>Pituitary Gland - embryology</topic><topic>Pregnancy</topic><topic>Prenatal development</topic><topic>Proliferating Cell Nuclear Antigen - analysis</topic><topic>Receptors, Androgen - analysis</topic><topic>Receptors, Androgen - biosynthesis</topic><topic>Sheep</topic><topic>Testosterone - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yuan, XueJun</creatorcontrib><creatorcontrib>He, YuQin</creatorcontrib><creatorcontrib>Liu, JiaLi</creatorcontrib><creatorcontrib>Luo, HaoShu</creatorcontrib><creatorcontrib>Zhang, JinHua</creatorcontrib><creatorcontrib>Cui, Sheng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Histochemistry and cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yuan, XueJun</au><au>He, YuQin</au><au>Liu, JiaLi</au><au>Luo, HaoShu</au><au>Zhang, JinHua</au><au>Cui, Sheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of androgen receptor and its co-localization with estrogen receptor-alpha in the developing pituitary gland of sheep fetus</atitle><jtitle>Histochemistry and cell biology</jtitle><addtitle>Histochem Cell Biol</addtitle><date>2007-04-01</date><risdate>2007</risdate><volume>127</volume><issue>4</issue><spage>423</spage><epage>432</epage><pages>423-432</pages><issn>0948-6143</issn><eissn>1432-119X</eissn><abstract>No information is known concerning the expression of androgen receptor (AR) and its co-localization with estrogen receptor alpha (ERalpha) in the developing pituitary of sheep fetus. In the present study, we detected AR expression and its co-localization with ERalpha in the anterior pituitary of sheep fetus from day 60 of gestation to the postnatal by dual immunochemistry. The results showed that both AR immunoreactivity (AR-ir) and ERalpha immunoreactivity (ERalpha-ir) were predominantly localized in the nuclei of LH positive gonadotropes. The cell counting results showed that the percentage of the anterior pituitary cells expressing AR fluctuated from 13.51 +/- 0.92 to 17.05 +/- 1.83% during the examined stages, but there were no significant differences between sexes and among ages examined (P > 0.05). However, the proportion of AR-ir cells containing LH markedly increased from day 60 of gestation to the neonatal (P < 0.05). The percentage of AR-ir cells expressing ERalpha-ir significantly increased from day 60 of gestation to the neonatal, respectively (P < 0.05), but no significant differences were seen between genders at each stage examined. These results indicate that both AR and ERalpha are mainly expressed in the gonadotropes of anterior pituitary gland of sheep fetuses, whereas the functions and interaction of AR and ERalpha expressions in the developing pituitary gland are required to be elucidated further.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>17205307</pmid><doi>10.1007/s00418-006-0262-6</doi><tpages>10</tpages></addata></record> |
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| ispartof | Histochemistry and cell biology, 2007-04, Vol.127 (4), p.423-432 |
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| subjects | Anatomy & physiology Animals Animals, Newborn Cellular biology Estrogen Receptor alpha - analysis Estrogens Female Fetus - chemistry Fetuses Gene expression Immunohistochemistry Male Pituitary gland Pituitary Gland - chemistry Pituitary Gland - cytology Pituitary Gland - embryology Pregnancy Prenatal development Proliferating Cell Nuclear Antigen - analysis Receptors, Androgen - analysis Receptors, Androgen - biosynthesis Sheep Testosterone - blood |
| title | Expression of androgen receptor and its co-localization with estrogen receptor-alpha in the developing pituitary gland of sheep fetus |
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