Local Interactions Select for Lower Pathogen Infectivity
Theory suggests that the current rapid increase in connectivity and consequential changes in the structure of human, agricultural, and wildlife populations may select for parasite strains with higher infectivity. We carried out a test of this spatial theory by experimentally altering individual host...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2007-03, Vol.315 (5816), p.1284-1286 |
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| creator | Boots, Michael Mealor, Michael |
| description | Theory suggests that the current rapid increase in connectivity and consequential changes in the structure of human, agricultural, and wildlife populations may select for parasite strains with higher infectivity. We carried out a test of this spatial theory by experimentally altering individual host movement rates in a model host/pathogen system by altering the viscosity of their environment. In our microevolutionary selection experiments, the infectivity of the virus was, as predicted by the theory, reduced in the most viscous populations. We therefore provide empirical support for the theory that population structure affects the evolution of infectious organisms. |
| doi_str_mv | 10.1126/science.1137126 |
| format | Article |
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We carried out a test of this spatial theory by experimentally altering individual host movement rates in a model host/pathogen system by altering the viscosity of their environment. In our microevolutionary selection experiments, the infectivity of the virus was, as predicted by the theory, reduced in the most viscous populations. We therefore provide empirical support for the theory that population structure affects the evolution of infectious organisms.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1137126</identifier><identifier>PMID: 17332415</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Association for the Advancement of Science</publisher><subject>Analysis of Variance ; Animal populations ; Animals ; Biological and medical sciences ; Biological Evolution ; Disease transmission ; Epidemiology. 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We carried out a test of this spatial theory by experimentally altering individual host movement rates in a model host/pathogen system by altering the viscosity of their environment. In our microevolutionary selection experiments, the infectivity of the virus was, as predicted by the theory, reduced in the most viscous populations. We therefore provide empirical support for the theory that population structure affects the evolution of infectious organisms.</description><subject>Analysis of Variance</subject><subject>Animal populations</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biological Evolution</subject><subject>Disease transmission</subject><subject>Epidemiology. Vaccinations</subject><subject>Evolution</subject><subject>Food</subject><subject>Food movements</subject><subject>Foodborne illnesses</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Granulovirus - pathogenicity</subject><subject>Granulovirus - physiology</subject><subject>Infectious diseases</subject><subject>Insect larvae</subject><subject>Insecta</subject><subject>Invertebrates</subject><subject>Larva - physiology</subject><subject>Larva - virology</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Moths - physiology</subject><subject>Moths - virology</subject><subject>Movement</subject><subject>Parasite hosts</subject><subject>Parasites</subject><subject>Pathogens</subject><subject>Pathology</subject><subject>Population structure</subject><subject>Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains</subject><subject>Selection, Genetic</subject><subject>Theory</subject><subject>Virology</subject><subject>Viruses</subject><subject>Viscosity</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks1rFEEQxRsxmM3q2ZM6BMxtTFX39NdRgprAgkLMeejprY6zzE7H7lkl_3162cGAlz01xfv1K6peMfYW4RMiV5fZ9zR6KoXQpX7BFghW1paDeMkWAELVBrQ8ZWc5bwCKZsUrdopaCN6gXDCzit4N1c04UXJ-6uOYq1sayE9ViKlaxb-Uqh9u-hXvaSxYKEr_p58eX7OT4IZMb-Z3ye6-fvl5dV2vvn-7ufq8qr00ZqpJa94YIGz0GqSwukOz1kYpdICuo2Bd6EJHaNGR75TpLGlH5JUKa6mUWLKLg-9Dir93lKd222dPw-BGirvcauCiacxxUEjOpTXyKMgRLTRgjoJojbBlkQU8_w_cxF0ay1qKmVCAlu-hywPkU8w5UWgfUr916bFFaPdhtnOY7Rxm-fF-tt11W1o_83N6Bfg4Ay6XFENyo-_zM2f28_L9IO8O3CZPMf3TebkPqUu3Jftw0IOLrbtPxePulgMKKLdTOoF4AnyTuYE</recordid><startdate>20070302</startdate><enddate>20070302</enddate><creator>Boots, Michael</creator><creator>Mealor, Michael</creator><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20070302</creationdate><title>Local Interactions Select for Lower Pathogen Infectivity</title><author>Boots, Michael ; Mealor, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c588t-e772480e147d05397b18d78661a01abef9afbfbe191aecb68b9e7aeec66fd5663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Analysis of Variance</topic><topic>Animal populations</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biological Evolution</topic><topic>Disease transmission</topic><topic>Epidemiology. Vaccinations</topic><topic>Evolution</topic><topic>Food</topic><topic>Food movements</topic><topic>Foodborne illnesses</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Granulovirus - pathogenicity</topic><topic>Granulovirus - physiology</topic><topic>Infectious diseases</topic><topic>Insect larvae</topic><topic>Insecta</topic><topic>Invertebrates</topic><topic>Larva - physiology</topic><topic>Larva - virology</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Moths - physiology</topic><topic>Moths - virology</topic><topic>Movement</topic><topic>Parasite hosts</topic><topic>Parasites</topic><topic>Pathogens</topic><topic>Pathology</topic><topic>Population structure</topic><topic>Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains</topic><topic>Selection, Genetic</topic><topic>Theory</topic><topic>Virology</topic><topic>Viruses</topic><topic>Viscosity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boots, Michael</creatorcontrib><creatorcontrib>Mealor, Michael</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boots, Michael</au><au>Mealor, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Local Interactions Select for Lower Pathogen Infectivity</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>2007-03-02</date><risdate>2007</risdate><volume>315</volume><issue>5816</issue><spage>1284</spage><epage>1286</epage><pages>1284-1286</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Theory suggests that the current rapid increase in connectivity and consequential changes in the structure of human, agricultural, and wildlife populations may select for parasite strains with higher infectivity. We carried out a test of this spatial theory by experimentally altering individual host movement rates in a model host/pathogen system by altering the viscosity of their environment. In our microevolutionary selection experiments, the infectivity of the virus was, as predicted by the theory, reduced in the most viscous populations. We therefore provide empirical support for the theory that population structure affects the evolution of infectious organisms.</abstract><cop>Washington, DC</cop><pub>American Association for the Advancement of Science</pub><pmid>17332415</pmid><doi>10.1126/science.1137126</doi><tpages>3</tpages></addata></record> |
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| ispartof | Science (American Association for the Advancement of Science), 2007-03, Vol.315 (5816), p.1284-1286 |
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| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Analysis of Variance Animal populations Animals Biological and medical sciences Biological Evolution Disease transmission Epidemiology. Vaccinations Evolution Food Food movements Foodborne illnesses Fundamental and applied biological sciences. Psychology General aspects Genetics of eukaryotes. Biological and molecular evolution Granulovirus - pathogenicity Granulovirus - physiology Infectious diseases Insect larvae Insecta Invertebrates Larva - physiology Larva - virology Medical sciences Microbiology Moths - physiology Moths - virology Movement Parasite hosts Parasites Pathogens Pathology Population structure Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains Selection, Genetic Theory Virology Viruses Viscosity |
| title | Local Interactions Select for Lower Pathogen Infectivity |
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