Cystatin C as a potential marker for relapse in patients with non-Hodgkin B-cell lymphoma
Abstract The concentration of cysteine protease inhibitor cystatin C was determined in sera from 59 patients with non-Hodgkin B-cell lymphoma using ELISA. The sera from 43 age and sex matched healthy blood donors served as controls. Cystatin C was significantly increased in sera of patients without...
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Veröffentlicht in: | Cancer letters 2007-04, Vol.248 (2), p.192-197 |
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Sprache: | eng |
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Zusammenfassung: | Abstract The concentration of cysteine protease inhibitor cystatin C was determined in sera from 59 patients with non-Hodgkin B-cell lymphoma using ELISA. The sera from 43 age and sex matched healthy blood donors served as controls. Cystatin C was significantly increased in sera of patients without therapy (mean 1136 ± SE 105.7 ng/ml, p = 0.00001) and with therapy (mean 1073 ± 52 ng/ml, p = 0.001) compared to controls (mean 819 ± 28 ng/ml). The highest levels were determined in sera of patients with a relapse (mean 1680 ± 196 ng/ml). By using immunofluorescence staining and confocal microscopy we determined immature dendritic cells as a major population of cystatin C positive cells in affected lymph nodes. Our study reports for the first time that cystatin C is a potential marker for relapse in patients with non-Hodgkin B-cell lymphoma. |
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ISSN: | 0304-3835 1872-7980 |
DOI: | 10.1016/j.canlet.2006.07.004 |