Current Development of Clinical Inhibitors of Poly(ADP-Ribose) Polymerase in Oncology

Poly(ADP-ribose) polymerase (PARP) is a nuclear enzyme that signals the presence of DNA damage by catalyzing the addition of ADP-ribose units to DNA, histones, and various DNA repair enzymes and by facilitating DNA repair. PARP has been gaining increasing interest as a therapeutic target for many di...

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Veröffentlicht in:	Clinical cancer research 2007-03, Vol.13 (5), p.1383-1388
Hauptverfasser:	RATNAM, Kapila, LOW, Jennifer A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - pharmacology Biological and medical sciences Clinical Repair Clinical Trials as Topic DNA Repair Enzyme Inhibitors - pharmacology Humans Medical sciences PARP Pharmacology. Drug treatments Poly(ADP-ribose) Polymerases - drug effects Poly(ADP-ribose) Polymerases - metabolism
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