Natural killer cells of Parkinson's disease patients are set up for activation: A possible role for innate immunity in the pathogenesis of this disease
Abstract Neuroinflammation in Parkinson's disease (PD) involves activation of microglia, participation of several inflammatory cytokines, prostaglandins, complement and systemic activation of natural killer (NK) cells, suggesting that innate immunity has a role in the pathogenesis of this disea...
Gespeichert in:
| Veröffentlicht in: | Parkinsonism & related disorders 2008-01, Vol.14 (1), p.46-51 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 51 |
|---|---|
| container_issue | 1 |
| container_start_page | 46 |
| container_title | Parkinsonism & related disorders |
| container_volume | 14 |
| creator | Mihara, Tomoko Nakashima, Manabu Kuroiwa, Ataru Akitake, Yoshiharu Ono, Kazuhiko Hosokawa, Masato Yamada, Tatsuo Takahashi, Mitsuo |
| description | Abstract Neuroinflammation in Parkinson's disease (PD) involves activation of microglia, participation of several inflammatory cytokines, prostaglandins, complement and systemic activation of natural killer (NK) cells, suggesting that innate immunity has a role in the pathogenesis of this disease. In this study, we examined NK activity and the expression of its regulatory molecules in peripheral lymphocytes of PD patients and compared the results with those of healthy controls. Expression of the inhibitory NKG2A receptors was significantly lower in PD, causing PD patients to be susceptible in a condition for NK activation after NK cells bind to target cells via these receptors. |
| doi_str_mv | 10.1016/j.parkreldis.2007.05.013 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70233223</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1353802007000983</els_id><sourcerecordid>70233223</sourcerecordid><originalsourceid>FETCH-LOGICAL-c427t-edad43fa52c0bc5277d150f8afc0a51520cc774eb02b37420709022143c587683</originalsourceid><addsrcrecordid>eNqNUsFu1DAQjRCItgu_gHyCU8LYjtcpB6RSQUGqAAk4W44zYb3rtYPtVNov4XdxuisqceJge6x5M0_z3lQVodBQoOvX22bScRfRDTY1DEA2IBqg_FF1TjvJa0HZ-nGJueB1BwzOqouUtlCAAvjT6oxKCWzN5Hn1-7POc9SO7KxzGIlB5xIJI_laCKxPwb9KpLCgTkgmnS36nIiOSBJmMk9kDJFok-1dyQX_hlyRKaRke4ckhnIteeu9zkjsfj97mw_lT_Lmvt0m_ESPyd5T5o39y_WsejJql_D56V1VPz68_379sb79cvPp-uq2Ni2TucZBDy0ftWAGeiOYlAMVMHZ6NKAFFQyMkbLFHljPZctAwiUwRltuRCfXHV9VL499pxh-zZiy2tu0iKA9hjmpohPnrJxV1R2BJpb5Io5qinav40FRUIspaqseTFGLKQqEKqaU0hcnjrnf4_BQeHKhAN4dAVgmvbMYVTJFaIODjWiyGoL9H5a3_zQxznprtNvhAdM2zNEXJRVViSlQ35blWHajSAJw2XH-B0nbugI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70233223</pqid></control><display><type>article</type><title>Natural killer cells of Parkinson's disease patients are set up for activation: A possible role for innate immunity in the pathogenesis of this disease</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Mihara, Tomoko ; Nakashima, Manabu ; Kuroiwa, Ataru ; Akitake, Yoshiharu ; Ono, Kazuhiko ; Hosokawa, Masato ; Yamada, Tatsuo ; Takahashi, Mitsuo</creator><creatorcontrib>Mihara, Tomoko ; Nakashima, Manabu ; Kuroiwa, Ataru ; Akitake, Yoshiharu ; Ono, Kazuhiko ; Hosokawa, Masato ; Yamada, Tatsuo ; Takahashi, Mitsuo</creatorcontrib><description>Abstract Neuroinflammation in Parkinson's disease (PD) involves activation of microglia, participation of several inflammatory cytokines, prostaglandins, complement and systemic activation of natural killer (NK) cells, suggesting that innate immunity has a role in the pathogenesis of this disease. In this study, we examined NK activity and the expression of its regulatory molecules in peripheral lymphocytes of PD patients and compared the results with those of healthy controls. Expression of the inhibitory NKG2A receptors was significantly lower in PD, causing PD patients to be susceptible in a condition for NK activation after NK cells bind to target cells via these receptors.</description><identifier>ISSN: 1353-8020</identifier><identifier>EISSN: 1873-5126</identifier><identifier>DOI: 10.1016/j.parkreldis.2007.05.013</identifier><identifier>PMID: 17702627</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Aged ; Aged, 80 and over ; Cytokines - metabolism ; Enzyme-Linked Immunosorbent Assay ; Female ; Flow Cytometry ; Humans ; Immunity, Innate ; Innate immunity ; Killer Cells, Natural - immunology ; Male ; Middle Aged ; Natural killer (NK) ; Neurology ; NK Cell Lectin-Like Receptor Subfamily C ; NKG2A ; NKG2D ; Parkinson Disease - immunology ; Parkinson's disease ; Receptors, Immunologic - metabolism ; Receptors, Natural Killer Cell ; Th1 Cells - immunology ; Th2 Cells - immunology</subject><ispartof>Parkinsonism & related disorders, 2008-01, Vol.14 (1), p.46-51</ispartof><rights>Elsevier Ltd</rights><rights>2007 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-edad43fa52c0bc5277d150f8afc0a51520cc774eb02b37420709022143c587683</citedby><cites>FETCH-LOGICAL-c427t-edad43fa52c0bc5277d150f8afc0a51520cc774eb02b37420709022143c587683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.parkreldis.2007.05.013$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17702627$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mihara, Tomoko</creatorcontrib><creatorcontrib>Nakashima, Manabu</creatorcontrib><creatorcontrib>Kuroiwa, Ataru</creatorcontrib><creatorcontrib>Akitake, Yoshiharu</creatorcontrib><creatorcontrib>Ono, Kazuhiko</creatorcontrib><creatorcontrib>Hosokawa, Masato</creatorcontrib><creatorcontrib>Yamada, Tatsuo</creatorcontrib><creatorcontrib>Takahashi, Mitsuo</creatorcontrib><title>Natural killer cells of Parkinson's disease patients are set up for activation: A possible role for innate immunity in the pathogenesis of this disease</title><title>Parkinsonism & related disorders</title><addtitle>Parkinsonism Relat Disord</addtitle><description>Abstract Neuroinflammation in Parkinson's disease (PD) involves activation of microglia, participation of several inflammatory cytokines, prostaglandins, complement and systemic activation of natural killer (NK) cells, suggesting that innate immunity has a role in the pathogenesis of this disease. In this study, we examined NK activity and the expression of its regulatory molecules in peripheral lymphocytes of PD patients and compared the results with those of healthy controls. Expression of the inhibitory NKG2A receptors was significantly lower in PD, causing PD patients to be susceptible in a condition for NK activation after NK cells bind to target cells via these receptors.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cytokines - metabolism</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Humans</subject><subject>Immunity, Innate</subject><subject>Innate immunity</subject><subject>Killer Cells, Natural - immunology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Natural killer (NK)</subject><subject>Neurology</subject><subject>NK Cell Lectin-Like Receptor Subfamily C</subject><subject>NKG2A</subject><subject>NKG2D</subject><subject>Parkinson Disease - immunology</subject><subject>Parkinson's disease</subject><subject>Receptors, Immunologic - metabolism</subject><subject>Receptors, Natural Killer Cell</subject><subject>Th1 Cells - immunology</subject><subject>Th2 Cells - immunology</subject><issn>1353-8020</issn><issn>1873-5126</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUsFu1DAQjRCItgu_gHyCU8LYjtcpB6RSQUGqAAk4W44zYb3rtYPtVNov4XdxuisqceJge6x5M0_z3lQVodBQoOvX22bScRfRDTY1DEA2IBqg_FF1TjvJa0HZ-nGJueB1BwzOqouUtlCAAvjT6oxKCWzN5Hn1-7POc9SO7KxzGIlB5xIJI_laCKxPwb9KpLCgTkgmnS36nIiOSBJmMk9kDJFok-1dyQX_hlyRKaRke4ckhnIteeu9zkjsfj97mw_lT_Lmvt0m_ESPyd5T5o39y_WsejJql_D56V1VPz68_379sb79cvPp-uq2Ni2TucZBDy0ftWAGeiOYlAMVMHZ6NKAFFQyMkbLFHljPZctAwiUwRltuRCfXHV9VL499pxh-zZiy2tu0iKA9hjmpohPnrJxV1R2BJpb5Io5qinav40FRUIspaqseTFGLKQqEKqaU0hcnjrnf4_BQeHKhAN4dAVgmvbMYVTJFaIODjWiyGoL9H5a3_zQxznprtNvhAdM2zNEXJRVViSlQ35blWHajSAJw2XH-B0nbugI</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Mihara, Tomoko</creator><creator>Nakashima, Manabu</creator><creator>Kuroiwa, Ataru</creator><creator>Akitake, Yoshiharu</creator><creator>Ono, Kazuhiko</creator><creator>Hosokawa, Masato</creator><creator>Yamada, Tatsuo</creator><creator>Takahashi, Mitsuo</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080101</creationdate><title>Natural killer cells of Parkinson's disease patients are set up for activation: A possible role for innate immunity in the pathogenesis of this disease</title><author>Mihara, Tomoko ; Nakashima, Manabu ; Kuroiwa, Ataru ; Akitake, Yoshiharu ; Ono, Kazuhiko ; Hosokawa, Masato ; Yamada, Tatsuo ; Takahashi, Mitsuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-edad43fa52c0bc5277d150f8afc0a51520cc774eb02b37420709022143c587683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cytokines - metabolism</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Humans</topic><topic>Immunity, Innate</topic><topic>Innate immunity</topic><topic>Killer Cells, Natural - immunology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Natural killer (NK)</topic><topic>Neurology</topic><topic>NK Cell Lectin-Like Receptor Subfamily C</topic><topic>NKG2A</topic><topic>NKG2D</topic><topic>Parkinson Disease - immunology</topic><topic>Parkinson's disease</topic><topic>Receptors, Immunologic - metabolism</topic><topic>Receptors, Natural Killer Cell</topic><topic>Th1 Cells - immunology</topic><topic>Th2 Cells - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mihara, Tomoko</creatorcontrib><creatorcontrib>Nakashima, Manabu</creatorcontrib><creatorcontrib>Kuroiwa, Ataru</creatorcontrib><creatorcontrib>Akitake, Yoshiharu</creatorcontrib><creatorcontrib>Ono, Kazuhiko</creatorcontrib><creatorcontrib>Hosokawa, Masato</creatorcontrib><creatorcontrib>Yamada, Tatsuo</creatorcontrib><creatorcontrib>Takahashi, Mitsuo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Parkinsonism & related disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mihara, Tomoko</au><au>Nakashima, Manabu</au><au>Kuroiwa, Ataru</au><au>Akitake, Yoshiharu</au><au>Ono, Kazuhiko</au><au>Hosokawa, Masato</au><au>Yamada, Tatsuo</au><au>Takahashi, Mitsuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Natural killer cells of Parkinson's disease patients are set up for activation: A possible role for innate immunity in the pathogenesis of this disease</atitle><jtitle>Parkinsonism & related disorders</jtitle><addtitle>Parkinsonism Relat Disord</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>14</volume><issue>1</issue><spage>46</spage><epage>51</epage><pages>46-51</pages><issn>1353-8020</issn><eissn>1873-5126</eissn><abstract>Abstract Neuroinflammation in Parkinson's disease (PD) involves activation of microglia, participation of several inflammatory cytokines, prostaglandins, complement and systemic activation of natural killer (NK) cells, suggesting that innate immunity has a role in the pathogenesis of this disease. In this study, we examined NK activity and the expression of its regulatory molecules in peripheral lymphocytes of PD patients and compared the results with those of healthy controls. Expression of the inhibitory NKG2A receptors was significantly lower in PD, causing PD patients to be susceptible in a condition for NK activation after NK cells bind to target cells via these receptors.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>17702627</pmid><doi>10.1016/j.parkreldis.2007.05.013</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1353-8020 |
| ispartof | Parkinsonism & related disorders, 2008-01, Vol.14 (1), p.46-51 |
| issn | 1353-8020 1873-5126 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70233223 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aged Aged, 80 and over Cytokines - metabolism Enzyme-Linked Immunosorbent Assay Female Flow Cytometry Humans Immunity, Innate Innate immunity Killer Cells, Natural - immunology Male Middle Aged Natural killer (NK) Neurology NK Cell Lectin-Like Receptor Subfamily C NKG2A NKG2D Parkinson Disease - immunology Parkinson's disease Receptors, Immunologic - metabolism Receptors, Natural Killer Cell Th1 Cells - immunology Th2 Cells - immunology |
| title | Natural killer cells of Parkinson's disease patients are set up for activation: A possible role for innate immunity in the pathogenesis of this disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T11%3A51%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Natural%20killer%20cells%20of%20Parkinson's%20disease%20patients%20are%20set%20up%20for%20activation:%20A%20possible%20role%20for%20innate%20immunity%20in%20the%20pathogenesis%20of%20this%20disease&rft.jtitle=Parkinsonism%20&%20related%20disorders&rft.au=Mihara,%20Tomoko&rft.date=2008-01-01&rft.volume=14&rft.issue=1&rft.spage=46&rft.epage=51&rft.pages=46-51&rft.issn=1353-8020&rft.eissn=1873-5126&rft_id=info:doi/10.1016/j.parkreldis.2007.05.013&rft_dat=%3Cproquest_cross%3E70233223%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70233223&rft_id=info:pmid/17702627&rft_els_id=S1353802007000983&rfr_iscdi=true |