Applications of carrier erythrocytes in delivery of biopharmaceuticals
Carrier erythrocytes, resealed erythrocytes loaded by a drug or other therapeutic agents, have been exploited extensively in recent years for both temporally and spatially controlled delivery of a wide variety of drugs and other bioactive agents owing to their remarkable degree of biocompatibility,...
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| Veröffentlicht in: | Journal of controlled release 2007-04, Vol.118 (2), p.145-160 |
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| container_issue | 2 |
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| container_title | Journal of controlled release |
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| creator | Hamidi, Mehrdad Zarrin, Adbolhossein Foroozesh, Mahshid Mohammadi-Samani, Soliman |
| description | Carrier erythrocytes, resealed erythrocytes loaded by a drug or other therapeutic agents, have been exploited extensively in recent years for both temporally and spatially controlled delivery of a wide variety of drugs and other bioactive agents owing to their remarkable degree of biocompatibility, biodegradability and a series of other potential advantages. Biopharmaceuticals, therapeutically significant peptides and proteins, nucleic acid-based biologicals, antigens and vaccines, are among the recently focused pharmaceuticals for being delivered using carrier erythrocytes. In this article, the potential applications of erythrocytes in drug delivery have been reviewed with a particular stress on the studies and laboratory experiences on successful erythrocyte loading and characterization of the different classes of biopharmaceuticals. |
| doi_str_mv | 10.1016/j.jconrel.2006.06.032 |
| format | Article |
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Biopharmaceuticals, therapeutically significant peptides and proteins, nucleic acid-based biologicals, antigens and vaccines, are among the recently focused pharmaceuticals for being delivered using carrier erythrocytes. 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Biopharmaceuticals, therapeutically significant peptides and proteins, nucleic acid-based biologicals, antigens and vaccines, are among the recently focused pharmaceuticals for being delivered using carrier erythrocytes. In this article, the potential applications of erythrocytes in drug delivery have been reviewed with a particular stress on the studies and laboratory experiences on successful erythrocyte loading and characterization of the different classes of biopharmaceuticals.</description><subject>Animals</subject><subject>Antigens - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Biological Products - administration & dosage</subject><subject>Biological Products - metabolism</subject><subject>Biopharmaceuticals delivery</subject><subject>Carrier erythrocytes</subject><subject>Carrier RBCs</subject><subject>Cellular carriers</subject><subject>Drug Carriers</subject><subject>Erythrocyte</subject><subject>Erythrocyte Transfusion - methods</subject><subject>Erythrocytes - metabolism</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Nucleic Acids - administration & dosage</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. 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| fulltext | fulltext |
| identifier | ISSN: 0168-3659 |
| ispartof | Journal of controlled release, 2007-04, Vol.118 (2), p.145-160 |
| issn | 0168-3659 1873-4995 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antigens - administration & dosage Biological and medical sciences Biological Products - administration & dosage Biological Products - metabolism Biopharmaceuticals delivery Carrier erythrocytes Carrier RBCs Cellular carriers Drug Carriers Erythrocyte Erythrocyte Transfusion - methods Erythrocytes - metabolism General pharmacology Humans Medical sciences Nucleic Acids - administration & dosage Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Proteins - administration & dosage Resealed erythrocytes Technology, Pharmaceutical - methods |
| title | Applications of carrier erythrocytes in delivery of biopharmaceuticals |
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