Inhibitory effects of natural plants of Jeju Island on elastase and MMP-1 expression
In order to search for new active cosmetic ingredients of natural origin, we screened about 60 plants collected from Jeju Island, which is located in the southernmost part of the Republic of Korea. We investigated their free radical scavenging activity, elastase inhibition activity, and reduction of...
Gespeichert in:
Veröffentlicht in: | Journal of cosmetic science 2007-01, Vol.58 (1), p.19-33 |
---|---|
Hauptverfasser: | , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 33 |
---|---|
container_issue | 1 |
container_start_page | 19 |
container_title | Journal of cosmetic science |
container_volume | 58 |
creator | Kim, Young Heui Kim, Ki Soo Han, Chang Sung Yang, Hong Chul Park, Sun Hee Ko, Kang Ii Lee, Soo Hee Kim, Ki Ho Lee, Nam Ho Kim, Jung Mi Son, Kyung-Hun |
description | In order to search for new active cosmetic ingredients of natural origin, we screened about 60 plants collected from Jeju Island, which is located in the southernmost part of the Republic of Korea. We investigated their free radical scavenging activity, elastase inhibition activity, and reduction of MMP-1 mRNA expression for the development of anti-aging ingredients as raw materials for use in cosmetics. In the free radical scavenging capacity assay, 12 extracts, including Typha orientalis (seed) and Torreya nucifera (leaf), showed significant free radical scavenging activity (up to SC(50)50% at 100 mug/ml). Among these extracts, Persicaria hydropiper (whole plant) extract showed the highest elastase inhibition activity (IC(50) = 46.7 mug/ml). In the MMP-1 expression assay using RT-PCR, Typha orientalis (seed), Pyrrosia hastata (root), and Capsicum annum (whole plant) showed slightly lower inhibition activity than EGCG, which was used as a control. Furthermore, four extracts, including Persicaria hydropiper (whole plant), Filipendula glaberrima (root), Nymphaea tetragona (root), and Camellia japonica (leaf), completely inhibited the expression of MMP-1 in human fibroblast cells. The results showed that four of the 60 plant extracts may hold potential for use as natural active ingredients for anti-aging cosmetics. |
format | Article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_70232914</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70232914</sourcerecordid><originalsourceid>FETCH-LOGICAL-p209t-80cbe2164a2d04a015ff151e299bbda9e91cccf9fedc405d9b49b4ae317bb2d53</originalsourceid><addsrcrecordid>eNo1kEtrwzAQhHVoaUKav1B06s2gp20dS-gjJaE9pGejx4o62JYrydD8-7okWRaWbxmGYW7Qkkomi6quywVap3Qk84iSE0ru0IJWXDBWyiU6bIfv1rQ5xBMG78HmhIPHg85T1B0eOz2cP-9wnPA2zexwGDB0OmWdAP_zfv9ZUAy_Y4SU2jDco1uvuwTry12hr5fnw-at2H28bjdPu2JkROWiJtYAo6XQzBGhCZXeU0mBKWWM0woUtdZ65cFZQaRTRsyrgdPKGOYkX6HHs-8Yw88EKTd9myx0c0gIU2oqwjhTVMzCh4twMj24Zoxtr-OpufbA_wDoaFm_</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70232914</pqid></control><display><type>article</type><title>Inhibitory effects of natural plants of Jeju Island on elastase and MMP-1 expression</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Kim, Young Heui ; Kim, Ki Soo ; Han, Chang Sung ; Yang, Hong Chul ; Park, Sun Hee ; Ko, Kang Ii ; Lee, Soo Hee ; Kim, Ki Ho ; Lee, Nam Ho ; Kim, Jung Mi ; Son, Kyung-Hun</creator><creatorcontrib>Kim, Young Heui ; Kim, Ki Soo ; Han, Chang Sung ; Yang, Hong Chul ; Park, Sun Hee ; Ko, Kang Ii ; Lee, Soo Hee ; Kim, Ki Ho ; Lee, Nam Ho ; Kim, Jung Mi ; Son, Kyung-Hun</creatorcontrib><description>In order to search for new active cosmetic ingredients of natural origin, we screened about 60 plants collected from Jeju Island, which is located in the southernmost part of the Republic of Korea. We investigated their free radical scavenging activity, elastase inhibition activity, and reduction of MMP-1 mRNA expression for the development of anti-aging ingredients as raw materials for use in cosmetics. In the free radical scavenging capacity assay, 12 extracts, including Typha orientalis (seed) and Torreya nucifera (leaf), showed significant free radical scavenging activity (up to SC(50)<30 microg/ml). Among these extracts, Nymphaea tetragona (rhizome) extract showed the highest free radical scavenging activity (SC(50)=4.7 microg/ml). In the anti-elastase inhibition assay, seven extracts, including Typha orientalis (seed) and Persicaria hydropiper (whole plant), showed high inhibitory activity (>50% at 100 mug/ml). Among these extracts, Persicaria hydropiper (whole plant) extract showed the highest elastase inhibition activity (IC(50) = 46.7 mug/ml). In the MMP-1 expression assay using RT-PCR, Typha orientalis (seed), Pyrrosia hastata (root), and Capsicum annum (whole plant) showed slightly lower inhibition activity than EGCG, which was used as a control. Furthermore, four extracts, including Persicaria hydropiper (whole plant), Filipendula glaberrima (root), Nymphaea tetragona (root), and Camellia japonica (leaf), completely inhibited the expression of MMP-1 in human fibroblast cells. The results showed that four of the 60 plant extracts may hold potential for use as natural active ingredients for anti-aging cosmetics.</description><identifier>ISSN: 1525-7886</identifier><identifier>PMID: 17342265</identifier><language>eng</language><publisher>United States</publisher><subject>Biphenyl Compounds - metabolism ; Cosmetics - pharmacology ; Enzyme Inhibitors - pharmacology ; Fibroblasts - cytology ; Fibroblasts - drug effects ; Fibroblasts - enzymology ; Formazans - chemistry ; Free Radical Scavengers - pharmacology ; Humans ; Hydrazines - metabolism ; Korea ; Matrix Metalloproteinase 1 - biosynthesis ; Matrix Metalloproteinase 1 - genetics ; Matrix Metalloproteinase 1 - metabolism ; Matrix Metalloproteinase Inhibitors ; Pancreatic Elastase - antagonists & inhibitors ; Pancreatic Elastase - biosynthesis ; Pancreatic Elastase - genetics ; Pancreatic Elastase - metabolism ; Picrates ; Plant Extracts - pharmacology ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - biosynthesis ; RNA, Messenger - genetics ; Skin - cytology ; Skin - drug effects ; Skin - enzymology ; Tetrazolium Salts - chemistry</subject><ispartof>Journal of cosmetic science, 2007-01, Vol.58 (1), p.19-33</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17342265$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Young Heui</creatorcontrib><creatorcontrib>Kim, Ki Soo</creatorcontrib><creatorcontrib>Han, Chang Sung</creatorcontrib><creatorcontrib>Yang, Hong Chul</creatorcontrib><creatorcontrib>Park, Sun Hee</creatorcontrib><creatorcontrib>Ko, Kang Ii</creatorcontrib><creatorcontrib>Lee, Soo Hee</creatorcontrib><creatorcontrib>Kim, Ki Ho</creatorcontrib><creatorcontrib>Lee, Nam Ho</creatorcontrib><creatorcontrib>Kim, Jung Mi</creatorcontrib><creatorcontrib>Son, Kyung-Hun</creatorcontrib><title>Inhibitory effects of natural plants of Jeju Island on elastase and MMP-1 expression</title><title>Journal of cosmetic science</title><addtitle>J Cosmet Sci</addtitle><description>In order to search for new active cosmetic ingredients of natural origin, we screened about 60 plants collected from Jeju Island, which is located in the southernmost part of the Republic of Korea. We investigated their free radical scavenging activity, elastase inhibition activity, and reduction of MMP-1 mRNA expression for the development of anti-aging ingredients as raw materials for use in cosmetics. In the free radical scavenging capacity assay, 12 extracts, including Typha orientalis (seed) and Torreya nucifera (leaf), showed significant free radical scavenging activity (up to SC(50)<30 microg/ml). Among these extracts, Nymphaea tetragona (rhizome) extract showed the highest free radical scavenging activity (SC(50)=4.7 microg/ml). In the anti-elastase inhibition assay, seven extracts, including Typha orientalis (seed) and Persicaria hydropiper (whole plant), showed high inhibitory activity (>50% at 100 mug/ml). Among these extracts, Persicaria hydropiper (whole plant) extract showed the highest elastase inhibition activity (IC(50) = 46.7 mug/ml). In the MMP-1 expression assay using RT-PCR, Typha orientalis (seed), Pyrrosia hastata (root), and Capsicum annum (whole plant) showed slightly lower inhibition activity than EGCG, which was used as a control. Furthermore, four extracts, including Persicaria hydropiper (whole plant), Filipendula glaberrima (root), Nymphaea tetragona (root), and Camellia japonica (leaf), completely inhibited the expression of MMP-1 in human fibroblast cells. The results showed that four of the 60 plant extracts may hold potential for use as natural active ingredients for anti-aging cosmetics.</description><subject>Biphenyl Compounds - metabolism</subject><subject>Cosmetics - pharmacology</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Fibroblasts - cytology</subject><subject>Fibroblasts - drug effects</subject><subject>Fibroblasts - enzymology</subject><subject>Formazans - chemistry</subject><subject>Free Radical Scavengers - pharmacology</subject><subject>Humans</subject><subject>Hydrazines - metabolism</subject><subject>Korea</subject><subject>Matrix Metalloproteinase 1 - biosynthesis</subject><subject>Matrix Metalloproteinase 1 - genetics</subject><subject>Matrix Metalloproteinase 1 - metabolism</subject><subject>Matrix Metalloproteinase Inhibitors</subject><subject>Pancreatic Elastase - antagonists & inhibitors</subject><subject>Pancreatic Elastase - biosynthesis</subject><subject>Pancreatic Elastase - genetics</subject><subject>Pancreatic Elastase - metabolism</subject><subject>Picrates</subject><subject>Plant Extracts - pharmacology</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - biosynthesis</subject><subject>RNA, Messenger - genetics</subject><subject>Skin - cytology</subject><subject>Skin - drug effects</subject><subject>Skin - enzymology</subject><subject>Tetrazolium Salts - chemistry</subject><issn>1525-7886</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kEtrwzAQhHVoaUKav1B06s2gp20dS-gjJaE9pGejx4o62JYrydD8-7okWRaWbxmGYW7Qkkomi6quywVap3Qk84iSE0ru0IJWXDBWyiU6bIfv1rQ5xBMG78HmhIPHg85T1B0eOz2cP-9wnPA2zexwGDB0OmWdAP_zfv9ZUAy_Y4SU2jDco1uvuwTry12hr5fnw-at2H28bjdPu2JkROWiJtYAo6XQzBGhCZXeU0mBKWWM0woUtdZ65cFZQaRTRsyrgdPKGOYkX6HHs-8Yw88EKTd9myx0c0gIU2oqwjhTVMzCh4twMj24Zoxtr-OpufbA_wDoaFm_</recordid><startdate>200701</startdate><enddate>200701</enddate><creator>Kim, Young Heui</creator><creator>Kim, Ki Soo</creator><creator>Han, Chang Sung</creator><creator>Yang, Hong Chul</creator><creator>Park, Sun Hee</creator><creator>Ko, Kang Ii</creator><creator>Lee, Soo Hee</creator><creator>Kim, Ki Ho</creator><creator>Lee, Nam Ho</creator><creator>Kim, Jung Mi</creator><creator>Son, Kyung-Hun</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200701</creationdate><title>Inhibitory effects of natural plants of Jeju Island on elastase and MMP-1 expression</title><author>Kim, Young Heui ; Kim, Ki Soo ; Han, Chang Sung ; Yang, Hong Chul ; Park, Sun Hee ; Ko, Kang Ii ; Lee, Soo Hee ; Kim, Ki Ho ; Lee, Nam Ho ; Kim, Jung Mi ; Son, Kyung-Hun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p209t-80cbe2164a2d04a015ff151e299bbda9e91cccf9fedc405d9b49b4ae317bb2d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Biphenyl Compounds - metabolism</topic><topic>Cosmetics - pharmacology</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Fibroblasts - cytology</topic><topic>Fibroblasts - drug effects</topic><topic>Fibroblasts - enzymology</topic><topic>Formazans - chemistry</topic><topic>Free Radical Scavengers - pharmacology</topic><topic>Humans</topic><topic>Hydrazines - metabolism</topic><topic>Korea</topic><topic>Matrix Metalloproteinase 1 - biosynthesis</topic><topic>Matrix Metalloproteinase 1 - genetics</topic><topic>Matrix Metalloproteinase 1 - metabolism</topic><topic>Matrix Metalloproteinase Inhibitors</topic><topic>Pancreatic Elastase - antagonists & inhibitors</topic><topic>Pancreatic Elastase - biosynthesis</topic><topic>Pancreatic Elastase - genetics</topic><topic>Pancreatic Elastase - metabolism</topic><topic>Picrates</topic><topic>Plant Extracts - pharmacology</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Messenger - biosynthesis</topic><topic>RNA, Messenger - genetics</topic><topic>Skin - cytology</topic><topic>Skin - drug effects</topic><topic>Skin - enzymology</topic><topic>Tetrazolium Salts - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Young Heui</creatorcontrib><creatorcontrib>Kim, Ki Soo</creatorcontrib><creatorcontrib>Han, Chang Sung</creatorcontrib><creatorcontrib>Yang, Hong Chul</creatorcontrib><creatorcontrib>Park, Sun Hee</creatorcontrib><creatorcontrib>Ko, Kang Ii</creatorcontrib><creatorcontrib>Lee, Soo Hee</creatorcontrib><creatorcontrib>Kim, Ki Ho</creatorcontrib><creatorcontrib>Lee, Nam Ho</creatorcontrib><creatorcontrib>Kim, Jung Mi</creatorcontrib><creatorcontrib>Son, Kyung-Hun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cosmetic science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Young Heui</au><au>Kim, Ki Soo</au><au>Han, Chang Sung</au><au>Yang, Hong Chul</au><au>Park, Sun Hee</au><au>Ko, Kang Ii</au><au>Lee, Soo Hee</au><au>Kim, Ki Ho</au><au>Lee, Nam Ho</au><au>Kim, Jung Mi</au><au>Son, Kyung-Hun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibitory effects of natural plants of Jeju Island on elastase and MMP-1 expression</atitle><jtitle>Journal of cosmetic science</jtitle><addtitle>J Cosmet Sci</addtitle><date>2007-01</date><risdate>2007</risdate><volume>58</volume><issue>1</issue><spage>19</spage><epage>33</epage><pages>19-33</pages><issn>1525-7886</issn><abstract>In order to search for new active cosmetic ingredients of natural origin, we screened about 60 plants collected from Jeju Island, which is located in the southernmost part of the Republic of Korea. We investigated their free radical scavenging activity, elastase inhibition activity, and reduction of MMP-1 mRNA expression for the development of anti-aging ingredients as raw materials for use in cosmetics. In the free radical scavenging capacity assay, 12 extracts, including Typha orientalis (seed) and Torreya nucifera (leaf), showed significant free radical scavenging activity (up to SC(50)<30 microg/ml). Among these extracts, Nymphaea tetragona (rhizome) extract showed the highest free radical scavenging activity (SC(50)=4.7 microg/ml). In the anti-elastase inhibition assay, seven extracts, including Typha orientalis (seed) and Persicaria hydropiper (whole plant), showed high inhibitory activity (>50% at 100 mug/ml). Among these extracts, Persicaria hydropiper (whole plant) extract showed the highest elastase inhibition activity (IC(50) = 46.7 mug/ml). In the MMP-1 expression assay using RT-PCR, Typha orientalis (seed), Pyrrosia hastata (root), and Capsicum annum (whole plant) showed slightly lower inhibition activity than EGCG, which was used as a control. Furthermore, four extracts, including Persicaria hydropiper (whole plant), Filipendula glaberrima (root), Nymphaea tetragona (root), and Camellia japonica (leaf), completely inhibited the expression of MMP-1 in human fibroblast cells. The results showed that four of the 60 plant extracts may hold potential for use as natural active ingredients for anti-aging cosmetics.</abstract><cop>United States</cop><pmid>17342265</pmid><tpages>15</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1525-7886 |
ispartof | Journal of cosmetic science, 2007-01, Vol.58 (1), p.19-33 |
issn | 1525-7886 |
language | eng |
recordid | cdi_proquest_miscellaneous_70232914 |
source | MEDLINE; Alma/SFX Local Collection |
subjects | Biphenyl Compounds - metabolism Cosmetics - pharmacology Enzyme Inhibitors - pharmacology Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - enzymology Formazans - chemistry Free Radical Scavengers - pharmacology Humans Hydrazines - metabolism Korea Matrix Metalloproteinase 1 - biosynthesis Matrix Metalloproteinase 1 - genetics Matrix Metalloproteinase 1 - metabolism Matrix Metalloproteinase Inhibitors Pancreatic Elastase - antagonists & inhibitors Pancreatic Elastase - biosynthesis Pancreatic Elastase - genetics Pancreatic Elastase - metabolism Picrates Plant Extracts - pharmacology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - biosynthesis RNA, Messenger - genetics Skin - cytology Skin - drug effects Skin - enzymology Tetrazolium Salts - chemistry |
title | Inhibitory effects of natural plants of Jeju Island on elastase and MMP-1 expression |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T05%3A52%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Inhibitory%20effects%20of%20natural%20plants%20of%20Jeju%20Island%20on%20elastase%20and%20MMP-1%20expression&rft.jtitle=Journal%20of%20cosmetic%20science&rft.au=Kim,%20Young%20Heui&rft.date=2007-01&rft.volume=58&rft.issue=1&rft.spage=19&rft.epage=33&rft.pages=19-33&rft.issn=1525-7886&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E70232914%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70232914&rft_id=info:pmid/17342265&rfr_iscdi=true |