Inhibitory effects of natural plants of Jeju Island on elastase and MMP-1 expression

In order to search for new active cosmetic ingredients of natural origin, we screened about 60 plants collected from Jeju Island, which is located in the southernmost part of the Republic of Korea. We investigated their free radical scavenging activity, elastase inhibition activity, and reduction of...

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Veröffentlicht in:Journal of cosmetic science 2007-01, Vol.58 (1), p.19-33
Hauptverfasser: Kim, Young Heui, Kim, Ki Soo, Han, Chang Sung, Yang, Hong Chul, Park, Sun Hee, Ko, Kang Ii, Lee, Soo Hee, Kim, Ki Ho, Lee, Nam Ho, Kim, Jung Mi, Son, Kyung-Hun
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container_issue 1
container_start_page 19
container_title Journal of cosmetic science
container_volume 58
creator Kim, Young Heui
Kim, Ki Soo
Han, Chang Sung
Yang, Hong Chul
Park, Sun Hee
Ko, Kang Ii
Lee, Soo Hee
Kim, Ki Ho
Lee, Nam Ho
Kim, Jung Mi
Son, Kyung-Hun
description In order to search for new active cosmetic ingredients of natural origin, we screened about 60 plants collected from Jeju Island, which is located in the southernmost part of the Republic of Korea. We investigated their free radical scavenging activity, elastase inhibition activity, and reduction of MMP-1 mRNA expression for the development of anti-aging ingredients as raw materials for use in cosmetics. In the free radical scavenging capacity assay, 12 extracts, including Typha orientalis (seed) and Torreya nucifera (leaf), showed significant free radical scavenging activity (up to SC(50)50% at 100 mug/ml). Among these extracts, Persicaria hydropiper (whole plant) extract showed the highest elastase inhibition activity (IC(50) = 46.7 mug/ml). In the MMP-1 expression assay using RT-PCR, Typha orientalis (seed), Pyrrosia hastata (root), and Capsicum annum (whole plant) showed slightly lower inhibition activity than EGCG, which was used as a control. Furthermore, four extracts, including Persicaria hydropiper (whole plant), Filipendula glaberrima (root), Nymphaea tetragona (root), and Camellia japonica (leaf), completely inhibited the expression of MMP-1 in human fibroblast cells. The results showed that four of the 60 plant extracts may hold potential for use as natural active ingredients for anti-aging cosmetics.
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We investigated their free radical scavenging activity, elastase inhibition activity, and reduction of MMP-1 mRNA expression for the development of anti-aging ingredients as raw materials for use in cosmetics. In the free radical scavenging capacity assay, 12 extracts, including Typha orientalis (seed) and Torreya nucifera (leaf), showed significant free radical scavenging activity (up to SC(50)&lt;30 microg/ml). Among these extracts, Nymphaea tetragona (rhizome) extract showed the highest free radical scavenging activity (SC(50)=4.7 microg/ml). In the anti-elastase inhibition assay, seven extracts, including Typha orientalis (seed) and Persicaria hydropiper (whole plant), showed high inhibitory activity (&gt;50% at 100 mug/ml). Among these extracts, Persicaria hydropiper (whole plant) extract showed the highest elastase inhibition activity (IC(50) = 46.7 mug/ml). In the MMP-1 expression assay using RT-PCR, Typha orientalis (seed), Pyrrosia hastata (root), and Capsicum annum (whole plant) showed slightly lower inhibition activity than EGCG, which was used as a control. Furthermore, four extracts, including Persicaria hydropiper (whole plant), Filipendula glaberrima (root), Nymphaea tetragona (root), and Camellia japonica (leaf), completely inhibited the expression of MMP-1 in human fibroblast cells. 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In the MMP-1 expression assay using RT-PCR, Typha orientalis (seed), Pyrrosia hastata (root), and Capsicum annum (whole plant) showed slightly lower inhibition activity than EGCG, which was used as a control. Furthermore, four extracts, including Persicaria hydropiper (whole plant), Filipendula glaberrima (root), Nymphaea tetragona (root), and Camellia japonica (leaf), completely inhibited the expression of MMP-1 in human fibroblast cells. 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inhibitors</topic><topic>Pancreatic Elastase - biosynthesis</topic><topic>Pancreatic Elastase - genetics</topic><topic>Pancreatic Elastase - metabolism</topic><topic>Picrates</topic><topic>Plant Extracts - pharmacology</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Messenger - biosynthesis</topic><topic>RNA, Messenger - genetics</topic><topic>Skin - cytology</topic><topic>Skin - drug effects</topic><topic>Skin - enzymology</topic><topic>Tetrazolium Salts - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Young Heui</creatorcontrib><creatorcontrib>Kim, Ki Soo</creatorcontrib><creatorcontrib>Han, Chang Sung</creatorcontrib><creatorcontrib>Yang, Hong Chul</creatorcontrib><creatorcontrib>Park, Sun Hee</creatorcontrib><creatorcontrib>Ko, Kang Ii</creatorcontrib><creatorcontrib>Lee, Soo Hee</creatorcontrib><creatorcontrib>Kim, Ki Ho</creatorcontrib><creatorcontrib>Lee, Nam Ho</creatorcontrib><creatorcontrib>Kim, Jung Mi</creatorcontrib><creatorcontrib>Son, Kyung-Hun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cosmetic science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Young Heui</au><au>Kim, Ki Soo</au><au>Han, Chang Sung</au><au>Yang, Hong Chul</au><au>Park, Sun Hee</au><au>Ko, Kang Ii</au><au>Lee, Soo Hee</au><au>Kim, Ki Ho</au><au>Lee, Nam Ho</au><au>Kim, Jung Mi</au><au>Son, Kyung-Hun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibitory effects of natural plants of Jeju Island on elastase and MMP-1 expression</atitle><jtitle>Journal of cosmetic science</jtitle><addtitle>J Cosmet Sci</addtitle><date>2007-01</date><risdate>2007</risdate><volume>58</volume><issue>1</issue><spage>19</spage><epage>33</epage><pages>19-33</pages><issn>1525-7886</issn><abstract>In order to search for new active cosmetic ingredients of natural origin, we screened about 60 plants collected from Jeju Island, which is located in the southernmost part of the Republic of Korea. 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In the MMP-1 expression assay using RT-PCR, Typha orientalis (seed), Pyrrosia hastata (root), and Capsicum annum (whole plant) showed slightly lower inhibition activity than EGCG, which was used as a control. Furthermore, four extracts, including Persicaria hydropiper (whole plant), Filipendula glaberrima (root), Nymphaea tetragona (root), and Camellia japonica (leaf), completely inhibited the expression of MMP-1 in human fibroblast cells. The results showed that four of the 60 plant extracts may hold potential for use as natural active ingredients for anti-aging cosmetics.</abstract><cop>United States</cop><pmid>17342265</pmid><tpages>15</tpages></addata></record>
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subjects Biphenyl Compounds - metabolism
Cosmetics - pharmacology
Enzyme Inhibitors - pharmacology
Fibroblasts - cytology
Fibroblasts - drug effects
Fibroblasts - enzymology
Formazans - chemistry
Free Radical Scavengers - pharmacology
Humans
Hydrazines - metabolism
Korea
Matrix Metalloproteinase 1 - biosynthesis
Matrix Metalloproteinase 1 - genetics
Matrix Metalloproteinase 1 - metabolism
Matrix Metalloproteinase Inhibitors
Pancreatic Elastase - antagonists & inhibitors
Pancreatic Elastase - biosynthesis
Pancreatic Elastase - genetics
Pancreatic Elastase - metabolism
Picrates
Plant Extracts - pharmacology
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - biosynthesis
RNA, Messenger - genetics
Skin - cytology
Skin - drug effects
Skin - enzymology
Tetrazolium Salts - chemistry
title Inhibitory effects of natural plants of Jeju Island on elastase and MMP-1 expression
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